Co-Founder, CSO at @proteinqure, @UofT @UWaterloo. Peptide Therapeutics, Structure-based Drug Design, Computational Biophysics, AI for Drug Discovery, Cats
Toronto, Ontario
Joined May 2009
- Tweets1.7K
- Following1.7K
- Followers1.3K
- Likes3K
A little extra pep in our steps for a great cause. @proteinqure joined the 2026 CIBC Run for the Cure, raising over $2,650 in support of breast cancer research!
Huge thanks to everyone who ran, donated, and supported our team, "Pep(tides) in Our Steps"! 💗
Gila monster gets the fame for exendin-4, but clearly reptiles have been fine-tuning GPCR signalling since the Mesozoic, science.org/doi/10.1126/scia…
Macrocycle and cyclic peptides FEP+ benchmarking, impressive how bad MM-GBSA is... pubs.acs.org/doi/10.1021/acs…
When you want to take the "Back Drawing Challenge" to the next level, elifesciences.org/articles/1…
Slopocalypse now. Caught ChatGPT providing citations to an entirely AI generated "journal" (no editorial board, no listed authors) peptidejournal.org/
Expired: "One-click binder design"
Tired: "One-sentence binder design"
Wired: "One-epic-saga binder design"
I'm not seeing much work done on human dispatch APIs. My agent seems suspiciously excited to make a programmatic TaskRabbit it can use to vicariously "touch grass"...
Democratising real-world drug discovery through agentic AI (doi.org/10.1016/j.drudis.202…). Putting these agents through the wringer with tasks like "What is the SMILES string of ibuprofen?"😇
Boltz Pro Tip: Don't know what your ligand is? Use atom element "X" for ambiguous atom type (ambiguous monomer ASN/ASP depicted rcsb.org/ligand/ASX). Accuracy not guaranteed 😅
Facebook Marketplace:
"Hello, is this still available?"
"Yes. Then you’re interested?"
"Only if it’s available."
"It is."
"Then I will consider it."
"We are considering."
(They do not move.)
Paper version deltas with LLMs is helpful here. v2 = no thesis change, strengthening on: conservative inference speed correction, clearer test-set framing, expanded UniRef time-series, and new embedding-based evidence that clustering enriches non-proteins. Data quality > scale.
Update v2:
biorxiv.org/content/10.1101/…
Yearly tradition to summarize my faves, 2025:
Song: "9 2 5", "Afterlife"
Album: "Baby" by Dijon
Movies: One Battle After Another, Sinners
Series: Chair Company, Severance S2, The Pitt S1
Comics: Drome
Game: Clair Obscur, Blue Prince
Anime: Chainsaw Man Reze Arc, To Be Hero X
