
Building something new. Founded IRL DIY Medtech @littledevices Make 🛠so MD+RNs invent @makerhealthco Rocket launching. Robotbio TEDFellow 🇪🇸🇭🇳 MIT➡️Emory
Jose.gomez.marquez on Threads
Joined April 2009
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Whirlwind jet into Iowa for a Unity Point St Luke’s hospital Maker Faire. Each year, it’s a unique vibe. 2024’s reflected a confident clinical community where health making is part of the fabric of innovative caring for patients with @makerhealthco @RHedgesRN @annakyoung
Jose Gomez-Marquez retweeted
However dumb you think the process for destroying USAID was, it was dumber.
This is from Nicholas Enrich's new book Into the Wood Chipper, describing a meeting with Trump-appointed USAID leadership *after* they had largely gutted the agency
Diagnostic Startup funding opportunity thanks NIH and ACME at @emory @GeorgiaTech acmepoct.org and apply here poctrn.org/acme-solicitation… #diagnostics #grants #globalhealth #microfluidics #poc
Jose Gomez-Marquez retweeted
🚨BREAKING: The "Cursor for scientific research" just dropped and it runs entirely inside Claude Code.
It's called claude-scientific-skills and it gives Claude 140 ready-to-use scientific skills from a single plugin install.
No API doc hunting. No library configuration. No duct-taped research pipelines.
It's powered by 28+ live scientific databases wired directly into Claude.
→ Describe your research goal in plain English
→ Claude finds the right skill automatically
→ Full pipeline runs: data retrieval → analysis → publication-ready output
→ Works across biology, chemistry, medicine, ML, and clinical research
All running inside Claude Code. Zero manual setup.
But it's not just a prompt library.
It's a full AI research lab:
→ Drug discovery: ChEMBL → RDKit → DiffDock → lead optimization in one prompt
→ Genomics: 10X data → Scanpy → GRN inference → pathway enrichment
→ Clinical: VCF → ClinVar → pharmacogenomics → patient report
→ Multi-omics: RNA-seq + proteomics + metabolomics integrated automatically
7.8k stars. 924 forks. MIT Licensed.
MacOS, Windows, Linux works everywhere Claude Code runs.
This is the moment AI stops being a chat tool and becomes an actual research partner.
Link in the first comment 👇
Jose Gomez-Marquez retweeted
Dempsey hit a chord—a topic that’s been lighting up my private conversations lately: *Post-Founder Archetypes*
The moment feels similar to 2008, when finance careers went from highly coveted to passé. The social hierarchy seems to run on these ~20-year cycles.
The question now: what comes next?
I'll go a step further than Dempsey. I'm predicting the rise of the *bricoleur*, in the Lévi-Strauss sense of the term: someone who can make and *remake* things with the tools at hand. There's never been a better time to be a maker of things and stories, including your own personal myths.
If you're unbound by the dogma of product/market fit, the world opens widely, ready to be remade by a small group of friends.
I've also noticed the most interesting people I know are having a *terrible* time answering the "what do you do?" question. They can tell you about a project they're working on, but they'll shirk any qualifying identity description, including and especially "founder".
My favorite analogy comes from biology: monopodial vs sympodial growth in trees. Monopodials (like redwoods) have one big trunk and aim for continuous vertical growth. Sympodials (like oaks) grow via multiple branches. The metabolic strategies are very different. Monopodials put all their energy into growing tall quickly, whereas the sympodial plants hedge with multiple different leading edges, which is more resilient.
The next high-status career will be sympodial. Or what @zebriez called Flounder Mode—moving from project to project with people you like, and not letting your identity get too tangled up with any one of them.
(New Essay) VC-Backed Startups are Low Status
The traditional VC-backed startup path is becoming low status in the same way investment banking did. An aesthetic collapse across institutions, ideas, and founders paired with the world's tiring of tech has recently accelerated this shift.
Some thoughts on the cascade, the generational divide, Anthropic vs. OpenAI, what comes next, and more.
Jose Gomez-Marquez retweeted
Anyone else being charged 5X the US customs duty due for "brokerage charges" by UPS? A $ 2.70 duty becomes a $16.70 bill #UPS #Tarrifs #inflation #costoflivingcrisis
Jose Gomez-Marquez retweeted
AI resources I work on that might be useful:
My NY Times bestseller, Co-Intelligence (now in 19 languages!): penguinrandomhouse.com/books…
The Generative AI Lab at Wharton (free prompts & research): gail.wharton.upenn.edu/resea…
OneUsefulThing, my free newsletter: oneusefulthing.org/
Jose Gomez-Marquez retweeted
They do not research medicines.
They do not manufacture medicines.
They do not dispense medicines.
So why are insurance companies making billions off medicines?
Jose Gomez-Marquez retweeted
The Dawn of Infinite Code
docs.google.com/document/d/1…
Jose Gomez-Marquez retweeted
A new lab model from @WilburLam & team can sustain blood clots for a long time, allowing detailed study of how they form and resolve. It opens new paths for treatment, with big implications for stroke, heart attack, sickle cell & more. Now out in @Nature. bit.ly/4i8M7L3
Jose Gomez-Marquez retweeted
"While dealing with the challenges of cancer, a 30-day supply of his medication costs $6,067.69 through his employer’s PBM. Of that, the employee paid $1,213.54 out-of-pocket, while his employer covered $4,854.15.
With RxSaveCard, the total cost of the drug is just $13.18 through @costplusdrugs. His employer pays $13.18 and the employee gets his cancer medication for free." medcitynews.com/2025/02/rxsa…
Jose Gomez-Marquez retweeted
Why are more residential homes not built with concrete?
Is it cost? Seismic code? Smth else?
This quoted post is unavailable.
Nerdy take: What if we did that for academic articles. Like directory commentary for the experiments: "Our undergrad insisted on an Arduino + a stepper motor after finding out how much a dip coater cost the lab, So we always bought the best pizza for lab meetings after that."
The in-game developer commentary in the 20th anniversary version of Half-Life 2 is so well-done. Floating speech bubbles through the game trigger a @valvesoftware developer talking about the gameplay, storytelling or technical challenges of that part of the game.
Even if you've played all three Half-Life 2 episodes before, it's worth going through them again to learn more about the making of this legendary game. Highly recommended
And it's free for the next two days!
theverge.com/2024/11/15/2429…
Jose Gomez-Marquez retweeted
As a booster of local startups, it gives me no pleasure to say this, but, if you are a tech startup, you should likely move to Silicon Valley
This careful paper shows that movers to the Valley from less promising ecosystems gain many benefits. Agglomeration is a hell of a thing
Every company in the world worth more than $1 trillion was founded on the US west coast, including Saudi Aramco which was started in the same building as @flexport here in San Francisco.
Jose Gomez-Marquez retweeted
Founder & CEO is a common title, especially in tech.
It happens to be my title too.
I've come to believe it's an impossible title. You're either CEO, or you're Founder. You can't hold both full-time jobs.
And unless your company is probably 100+, CEO isn't really a job anyway. It's more of a role someone needs to play occasionally.
There simply aren't that many big picture things or decisions to "execute" day in and day out — or even week in and week out — to make it a true full time job. A role yes, a hat to wear yes, a full-time job at a smallish company? No. It's part-time at best, quarter-time even better.
Further, the fundamental responsibilities of Founders and CEOs are at odds. Having them mashed up in the same title is as ridiculous as having someone who's a "CTO & Chief Luddite".
Why's that? Because a Founder's job is injecting risk into the business. It's flooding it with new ideas, stuff that seems hard to do, ideas that no one else would dare try, placing the kinds of bets that only someone who started the damn thing would be willing to wager. A Founders' job is basically to stay in business by almost always putting it out of business.
A CEO's job? Just about the opposite. It's reducing risk, executing diligently to achieve obvious goals, staying in business at all costs. It's primarily about about being conservative, keeping the company's collective cool, and not letting things get out of hand. Just about everything that a Founder isn't doing. A CEO's job is to stay in business by not allowing the company to do anything so stupid that it could go out of business.
See? They're such different things. The minds powering the pistons run on different fuel.
But I get it. It's a wonderful boost to the ego to hold the top two jobs in a company — especially when the original sin of starting the damn thing was your decision. And yes, someone ultimately has to make the big calls, no matter which side they fall on. And given that you were the first one in the door, you're the natural and convenient standard-bearer. Your skeleton key fits both locks.
Founder is a unique position as it's the one job that can't be replaced. It can be eliminated, certainly, as many companies go founder-free after some time. But once the person who started it isn't there, you can't bring someone else in who started it. The closest thing then becomes a CEO.
So I've shifted my personal thinking. As long as I'm still here, I'm picking a side. I'm a Founder. That's my strength, that's where I can bring the most. Which means we don't really have a full-time CEO. I'm simply the part time one that fills the void when we need to bridge the gap, make a final big decision, and move on. As it should be.
Jose Gomez-Marquez retweeted
In March 1945, a few weeks before we defeated Nazi Germany, the regular informational pamphlet Army Talks, sent to all U.S. soldiers and officers in Europe, was a primer on fascism. It’s remarkable to read now. For obvious reasons. archive.org/details/ArmyTalk…
h/t @HC_Richardson
Jose Gomez-Marquez retweeted
Maybe the most powerful figure I’ve seen this year: the racial gap in tickets from speed cameras vs. officer stops.
pnas.org/doi/10.1073/pnas.24…
Unpopular opinion: Panda's are overrated and overpriced. nytimes.com/2024/10/19/world…
This is excellent
Had a few closed door conversations with smart people concerned about AI this week. Here’s what I wish I told them:
- there is an opportunity for prophets and critics but they’ve got spend time with the actual tools to get an intuition for what’s possible, rather than what you’d assume based on reading old science fiction. Frankenstein is a terrific book partly based on how concerned people were about electricity. It captures our fears about the nature of being human but didn’t help anyone really come up with better policies for dealing with electricity. I worry that a lot of AI critics are doing the same thing.
- the tools are surprisingly accessible. I didn’t predict this but all of the big AI companies are spending an incredible amount of money to make their technology easy for people to use and sharing more about how they do it than I would have guessed. That’s not out of the goodness of their heart--they’ve got commercial reasons. But that is something you can use to your advantage!
- the tools are also oddly cheap! For the price of flying out to San Francisco, you can run a whole series of experiments with the current tools to actually see what is possible, report on it, and then run another set of experiments.
- the manifestos and policy papers are very good but everyone is still figuring out use cases so don’t spend all of your time worried about them. Remember ChatGPT’s success was a surprise. And the amazing NotebookLLM podcast I was showing off was subfeature of a subfeature. I think most at Google would admit they were surprised!
- you can find out about the limitations of the tools by trying them out yourself rather than reading about the limitations. And if you play enough with them, you’ll start to build guesses about the ways they will and won’t get better. You’ll also see how hallucinations are both overhyped and still kind of under-studied.
- I’m not a blind optimist. I would just love a world in which critics and prophets on the left and right illustrated their concerns with little demos and informed intuitions. There are lots of reasons to be worried, and lots of ideas that need to be reconsidered! But they should be grounded with the direction that the tools are going in right now, and the speculation should be on the second and third order effects of actual tools (which already are superhumanly intelligent in some ways), rather than an imaginary superhuman intelligences.









































