Developing transformative therapies for Type 2 Diabetes @fractylhealth | X opinions/posts are my own.
Boston, MA
Joined May 2013
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Jay Caplan retweeted
The gut is much more than a digestive organ. It is a metabolic sensing and signaling system that helps shape how we respond to food, regulate appetite, and control metabolism.
Really enjoyed going deep on this with Andrew Huberman, from gut biology and the microbiome to obesity, GLP-1 therapies, and endoscopic treatments.
The new Huberman Lab episode is out: Best Tools for Gut Health and Weight Loss | Dr. Chris Thompson
0:00 Dr. Chris Thompson
2:16 Digestive Tract, Gut Hormones & Nutrient Absorption
8:06 Colon Microbiome & Colon Cancer Screening
11:13 Sponsors: LMNT & Lingo
13:40 Swallowing Problems & Zenker's Diverticula
16:08 Bowel Movements & Constipation
18:28 Fiber, Resistant Starch & the Gut Barrier
21:50 Intermittent Fasting & the Gut Microbiome
23:38 Fermented Foods, Microbial Diversity & Butyrate
27:12 H. pylori, Stress & Stomach Ulcers
30:20 GLP-1 Medications: Benefits & Limitations
33:42 Lower GLP-1 Doses, Weight Regain & Muscle Loss
37:35 GLP-1 Side Effects, Food Noise & Apathy
39:49 Bariatric Surgery & Medical Innovation
46:07 Sponsor: AG1
47:44 Hunger & Satiety: Ghrelin, CCK, GIP & GLP-1
50:01 Retatrutide & Combining Hormonal Targets
52:55 Ultra-Processed Foods, Overeating & Leptin
55:32 Incretin Discovery, Exendin-4 & the Gila Monster
59:35 Endoscopic Ultrasound & Pancreatic Biopsy
1:07:40 Early Metabolic Markers, CGMs & Fasting Insulin
1:13:06 Insulin Resistance & Metabolic Flexibility
1:15:53 Sponsor: Function
1:17:35 Patient Data, Screening & Treatment Adoption
1:26:31 AI, Robotics & Improving Procedures
1:29:27 Choosing a Surgeon & Measuring Procedure Quality
1:35:29 Image Guidance & Hyperspectral Imaging
1:37:19 Sponsor: Our Place
1:38:56 Diagnostics & Targeted Metabolic Treatments
1:42:45 Gastric Bypass, Foregut Exclusion & Diabetes
1:47:59 Duodenal Liners & Mucosal Resurfacing Research
1:52:58 Gut Permeability, Inflammation & Fatty Liver
1:59:39 Artificial Sweeteners, Fructose, Fats & Omega-3s
2:05:00 Resistance Training, Zone 2 Cardio & Intervals
2:06:31 Weight Set Point & Metabolic Adaptation
2:08:13 Endoscopic Sleeve Gastroplasty & Fundus Ablation
2:10:30 Magnetic Intestinal Connections & Combined Treatments
2:16:52 GLP-1 Gene Therapy Research
2:22:13 Innovation, Problem Solving & Teamwork
2:25:58 Zero-Cost Support, Sponsors & Neural Network Newsletter
Includes paid partnerships.
Jay Caplan retweeted
The work never stops- it shouldn't stop either.
Something to help the #T1diabetes community - across #NHS
A little thing I have been working on based on feedback from many over the years- around travel, airport security and living with #T1D
If you already have something robust in place for all travels? No need to change
If you don't? This hopefully helps
Please use, cascade and discuss with clinicians as needed.
Letter sent out across NHS
(H/T @semarroy72 for the idea and the push)
Regards
Partha
@BT1DUK @DiabetesUK @DiabeticDadUK @diabetes_chat @DRWFDiabetes @mbrp1 @sugarydoc
Jay Caplan retweeted
I'm passionate about showing the privileged citizens of western democracies the horrors of socialism because I know what it's like to fall for the propaganda. thank you @reason for letting me tell this personal story about my political journey to and from the left. reason.com/2026/06/30/my-fam…
Jay Caplan retweeted
Diabetes researchers ejected from conference after criticizing White House. The editor of ADA journal Steve Kahn was nondisruptivedly handing out his recent editorial in ADA journal that criticized Trump NIH policies. Big mistake by @AmDiabetesAssn washingtonpost.com/health/20…
Jay Caplan retweeted
I grew up in apartheid S Africa, where muzzling of speech and encroachment on academic freedom were the norm. I came to the US to pursue a career in science. I never thought that at this stage of my career, I would ever experience my youth again. #StandUpForScience #ADA #ADA2026
Jay Caplan retweeted
Looking forward @DDWMeeting.
Exciting parts of #DDW is seeing innovative technologies that have the potential to truly change patient outcomes
Check out @FractylHealth Duodenal Mucosal Resurfacing (DMR) — science, actual procedure, and what lies ahead in metabolic endoscopy
Jay Caplan retweeted
People with #T1D deserve P3 clinical trials to study the cardioprotective and kidney-sparing actions of GLP-1 medicines nature.com/articles/s41591-0…
Jay Caplan retweeted
My essay in the Sunday Washington Post: “A viral infection can have devastating effects. I experienced this firsthand.” @AEIecon @PostOpinions
wapo.st/3MhEY0U
Jay Caplan retweeted
Joel Habener @MassGeneralNews @Harvard at one of the lab social gatherings in the mid 1980s with one of the labs talented research fellows, currently the President of @Penn Larry Jameson
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro @MassGeneralNews @TheEndoSociety @Harvard wsj.com/health/pharma/joel-h…
Jay Caplan retweeted
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro @MassGeneralNews @TheEndoSociety @Harvard wsj.com/health/pharma/joel-h…
Jay Caplan retweeted
12 former commissioners of the FDA came together to write a Perspectives piece for the New England Journal of Medicine; raising our concerns about recent changes to vaccine approval policy at the FDA and its implications for patients and public health.
Jay Caplan retweeted
Fantastic @DKThomp podcast with Drs. @seeleyrj and David Alessio (@DukeMedSchool) on #GLP1 - what they do, how, & current thinking on why they have such broad effects on metabolism & inflammation. podcasts.apple.com/us/podcas…
Jay Caplan retweeted
Honored to join the Board of Fractyl Health at such a pivotal moment. Revita® is advancing through late-stage development, and Rejuva® is preparing for first-in-human studies. Fractyl is redefining how we treat obesity and type 2 diabetes by addressing root causes, not just symptoms. Excited to help shape this next chapter.
Jay Caplan retweeted
Welcoming @MetabolicEndo and Ian Sheffield to our Board marks an important moment for Fractyl. Their expertise in pioneering new approaches to obesity care and in building healthcare businesses with lasting impact will help guide us through this next stage of growth.
I’m also grateful to Amy Schulman for her service and leadership on our Board, and for helping position Fractyl to seize the opportunities ahead.
Looking forward to the journey as we continue advancing Revita® and Rejuva® toward our goal of transforming metabolic care.
$GUTS #FractylForward
Revita® is for Investigational Use Only in the U.S. under Federal law. Rejuva® is in preclinical development and has not yet been assessed by regulatory agencies.
Jay Caplan retweeted
Happy special birthday to my friend and colleague the incomparable Jens Juul Holst @UCPH_Research @Metabolcenter @EASDnews @uni_copenhagen @novonordiskfond
Jay Caplan retweeted
For the rest of July, folks in the UK get 25% off when they preorder Food Intelligence (my book with @juliaoftoronto) at @Waterstones. waterstones.com/book/food-in…
Jay Caplan retweeted
Distilling the complexity of nutrient sensing along the gut via the enteric nervous system nature.com/articles/s41586-0…
Jay Caplan retweeted
Encouraging my Canadian endocrine colleagues to read this and at least inform themselves. .
Canada's media continues to ignore the scandal of paediatric gender medicine. Journalists echo activist misinformation and show no curiosity about one of medicine's greatest crimes.
My formal complaint to @globeandmail, signed by 41 Canadian physicians.
macdonaldlaurier.ca/far-too-…
Jay Caplan retweeted
Canada's media continues to ignore the scandal of paediatric gender medicine. Journalists echo activist misinformation and show no curiosity about one of medicine's greatest crimes.
My formal complaint to @globeandmail, signed by 41 Canadian physicians.
macdonaldlaurier.ca/far-too-…