Co-founder at @my_helix #DNAdiscovery
California, USA
Joined July 2012
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jameslu retweeted
New COVID-19 preprint by Helix shows Delta and Gamma displacing Alpha in the US.
Data from our viral surveillance and testing predict Delta will be dominant in a few weeks; early evidence shows growth is faster in counties with lower vaccination rates compared to gamma.
Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States medrxiv.org/cgi/content/shor… #medRxiv
jameslu retweeted
Where is Delta (B.1.627.1) rapidly taking off in the United States?
You get one guess
medrxiv.org/content/10.1101/…
Rapid work by the research team; clear need for viral surveillance to track mutations. Using the same methods as in the UK to track the H69/V79 mutation, we find the same pattern in the US, with a small but increasing trend since mid October
A thread on S gene drop out patterns in SARS-CoV-2 tests done at @my_helix .
Summary:
- we observe S gene drop out since mid October in US. Up to 0.5% last week.
- more sequencing of the virus is needed in the US.
blog.helix.com/sars-cov2_uk-…
Was great to work with the @HealthyNV team on our new publication demonstrating the clinical value of primary genetic screening in the population. Thanks @renownhealth @MayoClinicCIM @drisci
@my_helix for the support.
Thanks to @renownhealth, @DRIScience, @my_helix, and @MayoClinic for the support and academic contributions. Thanks to all the participants of the @HealthyNV - we can't do any of the work without you.
#COVID2019 Love the work on Antibody Tests, but before we start thinking about immunity certificates from population screening with serology we need higher specificity.
also demonstrates some of our most recent work building large scale genomic databases. come find us at #ashg
Amazing work by @my_helix research team. ~200K mito allele frequency database, 4x larger than other available tools. 47% of mito is invariant. Likely to greatly impact clinical interpretation. biorxiv.org/content/10.1101/…
@ATorkamani @atulbutte @RobertCGreen
jameslu retweeted
Selective constraints and pathogenicity of mitochondrial DNA variants inferred from a novel database of 196,554 unrelated individuals biorxiv.org/cgi/content/shor… #bioRxiv
Amazing work by @my_helix research team. ~200K mito allele frequency database, 4x larger than other available tools. 47% of mito is invariant. Likely to greatly impact clinical interpretation. biorxiv.org/content/10.1101/…
@ATorkamani @atulbutte @RobertCGreen
Working together with @renownhealth and @DRIScience we used HelixMTdb to better classify the likely pathogenicity of variants suspected to cause mitochondrial disease. Read our analysis now on @biorxivpreprint biorxiv.org/content/10.1101/…
jameslu retweeted
Genome-wide rare variant analysis for thousands of phenotypes in 54,000 exomes biorxiv.org/cgi/content/shor… #bioRxiv
congrats to the research teams @my_helix @HealthyNV on getting this test + validation study across >50,000 exomes + > 1,000 clinical phenotypes. Some great findings both of expected results and some novel things as well.
Excited to get our work out there on rare variant analyses for thousands of phenotypes in >50k exomes across two cohorts. This was a really fun analysis to do! @my_helix @HealthyNV
Excited about our new initiative with @AdventHealthCFL on the WholeMe initiative with a focus on FH and cardiac disease in the community #DNADay
Today we're thrilled to announce our partnership with AdventHealth Orlando, bringing the WholeMe study to 10,000 individuals in Florida. genomeweb.com/sequencing/hel…
jameslu retweeted
As one of the world’s largest producers of clinical exomes and approved @uk_biobank researcher, the @my_helix research team has done a first pass on the 50K exomes released last week, made some intriguing associations, and released a public resource. blog.helix.com/uk-biobank-he…
jameslu retweeted
A blog piece from researchers @my_helix on what they found in the recent #ukbiobank exome data release:
jameslu retweeted
In part two of the DataPoint Podcast interview, Helix co-founder SVP for Applied Genomics @jameslu20 discusses the importance of clinical quality sequencing and the possibilities for genetic testing as a foundational diagnostic. bit.ly/2F7lE1b
jameslu retweeted
"The tipping point for consumer genomics is here.” - Robin Thurston, Helix CEO sfchronicle.com/business/art…
jameslu retweeted
Today we’re pleased to be at @HowardU @Cobbresearchlab to support the 1000 African Diaspora Genome Project. Stay tuned for more about this exciting initiative.
Excited to be a part of this! xitter.cf/my_helix/status/964935…
Today we’re pleased to be at @HowardU @Cobbresearchlab to support the 1000 African Diaspora Genome Project. Stay tuned for more about this exciting initiative.
It was a privilege to be onstage with @dalygene. Huge respect for the amount of amazing science and the rigor of his work. xitter.cf/my_helix/status/930550…
Helix cofounder @jameslu20 closes out the day with a debate on non-clinical uses of personal genomic data with @dalygene. #BostonUYG #UYG
