Organic Chemistry Research Group at Imperial College London. Synthesis; Catalysis; Heterocycles. Updates on group news and papers. Account run by JAB
Imperial College
Joined June 2009
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Iron-Catalyzed Friedel–Crafts Reactions of Unactivated 3-Aryl-Oxetanols Exploiting HFIP Stabilization of Carbocations | The Journal of Organic Chemistry pubs.acs.org/doi/10.1021/acs…
Bull Group Chemistry retweeted
We're currently recruiting for a Professor of Chemistry working in:
- Medicinal chemistry
- Novel molecular therapeutic modalities
- Chemical biology
- AI-enabled therapeutic discovery
Interested? Apply now: imperial.ac.uk/jobs/search-j…
Do Amino-Oxetanes Resemble Amides? A Matched Molecular Pairs Property and Structural Comparison | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…
Our latest work on the synthesis of heterocyclic fragments out now:
Regio‐ and Stereocontrolled‐Synthesis of a Heterocycle Fragment Collection Using Palladium Catalyzed C‐H Arylation
doi.org/10.1002/chem.2025031…
Bull Group Chemistry retweeted
Hodan and Sarah's work in collaboration with @jamesabull and Phil Miller on transforming trifluoromethane (HFC-23) into fluoroalkenes is now out in @angew_chem here is the link: onlinelibrary.wiley.com/doi/…
Do Amino-Oxetanes Resemble Amides?
Check out our Matched Molecular Pairs study in @ChemRxiv comparing properties and structure.
Congrats @hikaruishikura and coworkers, in collaboration with Pfizer.
doi.org/10.26434/chemrxiv-20…
As asymmetric sulfur(VI) derivatives become more prevalent in the chemical sciences, especially in aza-derivatives, sulfoximines, sulfonimidamides, we have reviewed "The stereochemistry of substitution at S(VI)"
doi.org/10.1039/D5QO01043H
Congrats to Freeman and Peerawat on our recent @ChemRxiv - Synthesis of Cyclic Sulfilimines and Sulfoximines via Copper Mediated C(sp2)–H Sulfanylation of Benzylamines with a Catalytic Transient Directing Group.
chemrxiv.org/engage/chemrxiv…
Now published in ChemistryEurope: doi.org/10.1002/ceur.2025002…
Bull Group Chemistry retweeted
Synthesis of Cyclic Sulfilimines and Sulfoximines via Copper-Mediated C(sp2)–H Sulfanylation of Benzylamines with a Catalytic Transient Directing Group by James A. Bull and co-workers (@jamesabull, @imperialcollege) #OpenAccess 🔓 onlinelibrary.wiley.com/doi/…
Bull Group Chemistry retweeted
New orthogonal SuFEx and SNAr reactivity of sulfonimidoyl fluorides and the automated synthesis of sulfonimidamides by @jamesabull and coworkers (@imperialcollege) #OpenAccess 🔓 onlinelibrary.wiley.com/doi/…
Our work on the divergent synthesis of difluorocyclobutanes, now published in #JOC @JOC_OL.
Synthesis of gem-Difluorocyclobutanes: Organolanthanum Enabled Synthesis and Divergent Catalytic Functionalization of gem-Difluorocyclobutanols pubs.acs.org/doi/10.1021/acs…
Interested in strained rings or fluorine for medicinal chemistry - check out Hikaru’s work on divergent synthesis of difluorocyclobutanes, on ChemRxiv:
doi.org/10.26434/chemrxiv-20…
SuFEx and SNAr on Sulfonimidoyl Fluorides - pleased this is now published in @ChemistryEur.
Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions chemistry-europe.onlinelibra…
Happy to report our work on catalytic SuFEx with sulfonimidoyl fluorides - and switchable SNAr reacts also. Congrats to Nikki on her paper now on ChemRxiv
doi.org/10.26434/chemrxiv-20…
Electrochemical Copper Catalysis: A Triple Catalytic System for Transient C(sp2)–H Functionalization Through Mediated Electrolysis | @ChemRxiv
Congrats Freeman @TszKanMa1
doi.org/10.26434/chemrxiv-20…
Interested in strained rings or fluorine for medicinal chemistry - check out Hikaru’s work on divergent synthesis of difluorocyclobutanes, on ChemRxiv:
doi.org/10.26434/chemrxiv-20…
Happy to report our work on catalytic SuFEx with sulfonimidoyl fluorides - and switchable SNAr reacts also. Congrats to Nikki on her paper now on ChemRxiv
doi.org/10.26434/chemrxiv-20…
** New PhD position ** We are advertising a chemical biology studentship with Profs Vilar and Mann, in collaboration with GSK, with ICB CDT @icbcdt .
#automation, #Synthesis, #D2B.
Fully funded at UK fees level.
findaphd.com/phds/project/de…
Bull Group Chemistry retweeted
Did you miss Ulrich Luecking’s talk about "Sulfoximines in Medicinal Chemistry: Unlocking Novel Opportunities in Drug Design"?
In this Flash Talk, Ulrich Luecking, VP and Head of Chemistry at FoRx Therapeutics, explores the untapped potential of sulfoximines in modern drug discovery. He highlights several exciting development candidates on novel and established targets such as AZ's ATR inhibitor ceralasertib, Artios' ATR inhibitor ART0380, Tango's CoREST complex inhibitor TNG-260, and many more. Ulrich also showcases the use of sulfoximines beyond traditional small molecules and exemplifies innovative synthetic strategies for accessing them.
A standout moment in the talk was the first time disclosure of FORX-1589, a covalent WRN inhibitor featuring a novel vinyl sulfoximine warhead. The patent application containing this compound was just published last week.
The Flash Talk concluded with a lively Q&A where Ulrich answered many insightful audience questions. Watch the full Flash Talk on our YouTube channel now and don't forget to share it with a colleague who'd appreciate knowing more about the use of sulfoximines as an innovative functional group!
Watch Now: drughunters.com/42skhot
Bull Group Chemistry retweeted
Last update of our "useful link" website: we added a few computational tools and compound databases useful for organic chemists! (Just a start, happy to add more in the future)
epfl.ch/labs/lcso/group/link…
We are advertising a 2nd fully funded PhD studentship with @TateScience and @icbcdt for October -
New dimensions for covalent enantioprobe chemoproteomics
#chemicalbiology, #synthesis, #chemoproteomics, #CHfunctionalisation.
findaphd.com/phds/project/ne…
