Finishing PhD candidate at Paris Brain Institute. Now in BlueSky: https://xitter.cf/t.co/9lAp9XHdrl
Joined October 2022
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Taking the momentum of our new-fresh-out-of-the-oven pre-print to fully move to BlueSky.
Check the post to check the work: bsky.app/profile/ivanmindlin…
See you there :)
📢 Registration extension📢
Join us in the Embracing Complexity Workshop: Principled and Practical Approaches to Emergence!
The workshop is scheduled for June 23-27 2025 at the Institute for Cross-Disciplinary Physics and Complex Systems in Palma de Mallorca, Spain 🇪🇸
👇👇👇
Registration is open until April 25. No abstract is needed, but we encourage to submit (even with preliminary work 😉)
More info at ifisc.uib-csic.es/en/events/…
Registration HERE:
forms.gle/eQhWYyC3mjd6EhYC9
Hope to see you there ☀️
📢Paper out📢
“Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness”
nature.com/articles/s42003-0…
👇Brief summary below👇 (1/8)
In conclusion, our in-silico representation of patients hints that healthy-like brain dynamics might be recovered from DoC models through pharmacological perturbations, especially via serotonergic and opioid receptors, offering mechanistic insights into their effects. (8/8)
Many thanks to @jdsitt and @ysanz6 for your supervision🧠, @ETagliazucchi and all the coauthors for the ideas and discussion 💪
Interestingly, these shifts did not correlate with the receptor's similarity to structural connectivity but with the overall density of the receptor map. 5HT-2A receptors were more sensitive to perturbations. (7/8)
🚨First PhD preprint 🚨Here we propose a methodology for pharmacological treatment development of DoC. Our model suggests that high density receptors like 5HT2A and 5HT1A are the optimal to recuperate healthy-like dynamics in a DoC model.
biorxiv.org/content/10.1101/…
