PhD Candidate in Chemical Biomolecular Engineering at University of Delaware|| MIT ‘23 ChemE ||#synbio#rulez 🔥🥼🧬
Cambridge, MA
Joined September 2015
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Pragati Muthukumar retweeted
Discover a bioengineering breakthrough: a novel synthetic protein degradation circuit using Sortase A for precise control, enhancing BioPROTACs beyond traditional roles! 🧬✨ PMID:41027936, Nat Commun 2025, @NatureComms doi.org/10.1038/s41467-025-6… #AI #Pharma #BioMed #RNA #ASHG #ESHG
Pragati Muthukumar retweeted
Supreme Court won't overturn its landmark precedent recognizing a constitutional right to same-sex marriage. cnn.it/48bVve3
Pragati Muthukumar retweeted
🤔How do you design a promoter for stable titration of expression?
💡Try programmable promoter editing with DIAL!
📰Now published at @NatureBiotech 🧵 [1/n]
🔗 below
BioPROTACs are proteins designed for targeted protein degradation(TPD) Here, we demonstrate the first major application of Sortase A cleavage & ligation as a control mechanism for synthetic circuitry to control TPD in a mammalian cell system.
nature.com/articles/s41467-0…
Thank you @hoppen1 for leading this impactful work @WilfredChen1 for being such a wonderful and supportive advisor.
Pragati Muthukumar retweeted
Many scientists are proud of their craft and the highly specialized skills they hone at the bench
But nobody hates Western Blots more than the people who have to do them
Pragati Muthukumar retweeted
When Roe was overturned and women bled out in ERs, we heard “states’ rights. When guns became the #1 killer of kids, still “states’ rights.” But one protest against injustice? Suddenly there’s federal boots on the ground. They don’t panic when people die, only when they speak.
Pragati Muthukumar retweeted
Today at @CellSystemsCP we report in back-to-back papers (!) led by @nbwang22 on how cell state potentiates the influence of individual transcription factors to drive cell-fate programming
&
how we used these insights to scale up production of motor neurons from primary fibroblasts, allowing us to deliver these directly converted neurons into the brains of mice.
Updated tweetorial coming soon (links below!)
Science Advances posted a collection of articles covering key scientific discoveries around women’s health. science.org/doi/10.1126/scia…
#womenhealth #Science #discovery
I am so beyond grateful to have been apart of @GallowayLabMIT as an undergraduate UROP student since my Sophomore year!!! I couldn’t have asked for a more supportive and intellectually stimulating lab environment! Thank you Professor Galloway and Chris Johnstone!
Pragati Muthukumar retweeted
Congratulations, Class of #MIT2023! 👏
Pragati Muthukumar retweeted
2. The FDA approved a vaccine for RSV, which hospitalizes some 60,000 seniors each year.
The vaccine reduced the risk of developing severe RSV infections by 94.1 percent. It's a success story that is *literally* 60 years in the making.
arstechnica.com/science/2023…
Pragati Muthukumar retweeted
3. A "vaccine printer" can load mRNA or other vaccines into a microneedle patch, and immunize mice just as well as traditional injections.
The patches can also be stored for 6 months at room temperature! A big deal for low resource countries.
nature.com/articles/s41587-0…
Pragati Muthukumar retweeted
1. Fusing a protein from HIV to Cas9, and then incubating this protein with peptides, helps gene editors better enter cells.
This is a big deal. The approach is probably transferrable to other proteins, including Cas12, base editors, prime editors, etc.
nature.com/articles/s41587-0…
Pragati Muthukumar retweeted
Please come join us for the 2023 Rising Stars in ChemE! This is such a great experience!
2023 Rising Stars in ChemE application now open! Early-career women interested in ChemE faculty careers encouraged to apply for this fall workshop. Apps due May 15. ow.ly/rxMR50NQE98 @MITEngineering @ChEnected @NOBCChE @SWEtalk
