@interactivefly

Drosophila neurobiology, bioinformatics, gene function and regulation, developmental biology

 Washington, DC
sdbonline.org/sites/fly/aimain/1aahome.htm
Joined April 2015
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12Media
Galletta, B. J., Konstantinidou, P., Haase, A. D., Rusan, N. M. (2025). A deficiency screen identifies genomic regions critical for sperm head-tail connection. G3 (Bethesda), 15(2) academic.oup.com/g3journal/a…

A deficiency screen identifies genomic regions critical for sperm head–tail connection

Abstract. The Sperm Neck provides a stable connection between the sperm head and tail, which is critical for fertility in species with flagellated sperm. W

academic.oup.com
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Riparbelli, M. G., Migliorini, M., Callaini, G. (2025). Astral Microtubules Are Dispensable for Pavarotti Localization During Drosophila Spermatogonial Mitoses. Cytoskeleton (Hoboken, NJ) onlinelibrary.wiley.com/doi/…

Astral Microtubules Are Dispensable for Pavarotti Localization During Drosophila Spermatogonial...

We analysed here the dynamic of the kinesin-like Pavarotti (Pav) during male gametogenesis of wild-type and Sas4 mutant flies. Pav localizes to the equatorial region and the inner central spindle of...

onlinelibrary.wiley.com
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Mao, B., Wang, Y. Y., Li, S., Fu, Y., Xiao, Y., Wang, Y. (2025). A potential role for the interaction of Wolbachia surface proteins with the Drosophila microtubulin in maintenance of endosymbiosis and affecting spermiogenesis. J Insect Physiol, 160:104743 sciencedirect.com/science/ar…
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Das, S., Hegde, S., Wagh, N., Sudhakaran, J., Roy, A. E., Deshpande, G., Ratnaparkhi, G. S. (2024). Caspar specifies primordial germ cell count and identity in Drosophila melanogaster. Elife, 13 elifesciences.org/articles/9…

Caspar specifies primordial germ cell count and identity in Drosophila melanogaster

During Drosophila primordial germ cells (PGCs) specification, the centrosome and germplasm are subject to regulation, during the maternal zygotic transition, by Caspar/TER94-dependent degradative...

elifesciences.org
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Azlan, A., Zhu, L., Fukunaga, R. (2025). Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis. bioRxiv biorxiv.org/content/10.1101/…
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Milano, S. N., Bayer, L. V., Ko, J. J., Casella, C. E., Bratu, D. P. (2025). The role of ER exit sites in maintaining P-body organization and integrity during Drosophila melanogaster oogenesis. EMBO Rep, 26(2):494-520 link.springer.com/article/10…
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Chavan, A., Skrutl, L., ...., Brennecke, J., Jagannathan, M. (2025). Characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression. PLoS biology, 23(1):e3002984 journals.plos.org/plosbiolog…
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Pazhayam, N. M., Sagar, S., Sekelsky, J. (2024). Suppression of meiotic crossovers in pericentromeric heterochromatin requires synaptonemal complex and meiotic recombination factors in Drosophila melanogaster. bioRxiv, biorxiv.org/content/10.1101/…
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Babosha, V., Klimenko, N., Revel-Muroz, A., Tikhonova, E., Georgiev, P., Maksimenko, O. (2024). N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation. Elife, 13 elifesciences.org/articles/9…

N-terminus of Drosophila melanogaster MSL1 is critical for dosage compensation

N‑terminus of MSL1 protein, involved in dosage compensation in Drosophila, is required for the interaction with non-coding roX2 RNA and the assembly of the complex on the male X chromosome.

elifesciences.org
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Morledge-Hampton, B., Selvam, K., Chauhan, M., Goodman, A., Wyrick, J. J. (2025). Ultraviolet damage and repair maps in Drosophila reveal the impact of domain-specific changes in nucleosome repeat length on repair efficiency. Genome research, 35(2):257-267 genome.cshlp.org/content/ear…

Ultraviolet damage and repair maps in Drosophila reveal the impact of domain-specific changes in...

Cyclobutane pyrimidine dimers (CPDs) are formed in DNA following exposure to ultraviolet (UV) light and are mutagenic unless repaired by nucleotide excision repair (NER). It is known that CPD repair...

genome.cshlp.org
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Fitz-James, M. H., Sabaris, G., Sarkies, P., Bantignies, F., Cavalli, G. (2025). Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila. Mol Cell, 85(4):677-691 cell.com/molecular-cell/full…

Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic...

In some cases, non-genetic information can be inherited across generations. Fitz-James et al. investigate the mechanism by which such epigenetic information becomes heritable in fruit flies. They...

cell.com
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Colmenares, S. U., Tsukamoto, S., Hickmann, C., Brennan, L. D., Khavani, M., Mofrad, M., Karpen, G. (2024). Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly. bioRxiv, biorxiv.org/content/10.1101/…
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Li, M., Wang, Y., Wei, X., Cai, W. F., Wu, J., Zhu, M., Wang, Y.,...., Han, J., Zhang, C. S., Lin, S. C. (2024). AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res, 34(10):683-706 nature.com/articles/s41422-0…

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

Cell Research - AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

nature.com
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El Fissi, N., Rosenberger, F. A., Chang, K., ...., Wedell, A., Mann, M., Chinnery, P. F., Freyer, C., Wredenberg, A. (2024). Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster. Nat Commun, 15(1):10719 nature.com/articles/s41467-0…

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila...

Nature Communications - Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae...

nature.com
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Chen, Y., Hu, J., Zhao, P., Fang, J., Kuang, Y., Liu, Z., ...., Tang, K., Yang, B., Liu, W., Sun, Q., Mei, K., Zou, W., Huang, Y., Feng, D., Yi, C. (2025). Rpl12 is a conserved ribophagy receptor. Nat Cell Biol, 27(3):477-492 nature.com/articles/s41556-0…
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Wang, L., Yi, S., Zhang, S., Tsai, Y. T., Cheng, Y. H., Lin, Y. T., Lin, C. C., Lee, Y. H., Wang, H., Ho, M. S. (2025). New Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia. ASN Neuro, 17(1):2443442 tandfonline.com/doi/10.1080/…

New Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia

We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson’s disease (PD). To further dissect the mechanism, we...

tandfonline.com
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Sadanandappa, M. K., Bosco, G. (2024). Olfactory inputs regulate Drosophila melanogaster oogenesis. J Exp Biol, 227(24) journals.biologists.com/jeb/…
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Bhadauriya, P., Onkar, A., Nagarajan, K., Angamuthu Karuppusamy, K., Ganesh, S., Agarwal, S. (2025). Glycogen synthase is required for heat shock-mediated autophagy induction in neuronal cells. Biology open, 14(2) journals.biologists.com/bio/…

Glycogen synthase is required for heat shock-mediated autophagy induction in neuronal cells

Summary: This study shows that heat shock increases glycogen synthase (GS) activity and levels. This study also shows that HSF1 regulates GS activation, and that GS is necessary for autophagy...

journals.biologists.com
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Edwards, S., Naundrup, A., Becher, P. G., De Fine Licht, H. H. (2025). Patterns of genotype-specific interactions in an obligate host-specific insect pathogenic fungus. J Evol Biol, 38(2):225-239 academic.oup.com/jeb/article…

Patterns of genotype-specific interactions in an obligate host-specific insect pathogenic fungus

Abstract. Host–pathogen infections and possible effects on co-evolutionary patterns depend on the genotypes of both host and pathogen. Obligate fungal path

academic.oup.com
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Jezovit, J. A., Levine, J. D. (2025). Chemical signals and social structures strengthen sexual isolation in Drosophila pseudoobscura. Communications biology, 8(1):76 nature.com/articles/s42003-0…

Chemical signals and social structures strengthen sexual isolation in Drosophila pseudoobscura

Communications Biology - An experimental evolution study on Drosophila sister species suggests that quantitative differences in cuticular hydrocarbons and in social structures shift across the...

nature.com
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