molecular microbiologist. Deputy director, AIMI@UTS Studying shapeshifting shenanigans of microbes - haloarchaea and uropathogenic E. coli (UPEC) - UTI
Sydney, Australia
Joined April 2011
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Iain Duggin retweeted
One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event?🦠🏃♂️
Iain Duggin retweeted
📣 New paper alert! One of the most exciting projects we've done in recent years is now out on BioRxiv: "An Asgard archaeon from a modern analog of ancient microbial mats".
Glimpse into early complex life! ❄️🦠 🔬🧬
biorxiv.org/content/10.1.... A thread...
Iain Duggin retweeted
New paper alert!
MinD is famously known for positioning FtsZ at mid-cell in bacteria
In our study, myself and
@iduggin found that MinD homologues in H. volcanii influence the localisation of CetZ1, a homologue of FtsZ and tubulin
#Archaea #microbiology
frontiersin.org/journals/mic…
Iain Duggin retweeted
What a sugar rush! Today was 2024 MIF Great Microscopy Bake-off @UTS_Science. Sponsored by @AIMI_UTS & @NikonInst. Well done to all the winners. Thx to judges @iduggin Errin Johnson & Anthea Leonard. Expect more posts with details of each bake! @micro_au @UTSResearch @UTSEngage
Iain Duggin retweeted
I’m SO happy to share the preprint of the final chapter of my PhD
This work started way back in 2018 so it feels very special and bit surreal to see it all together 🥹
It’s a super cool story about two CetZs coordinating their functions to control cell morphogenesis
1/3
Tubulin-like proteins CetZ1 and CetZ2 coordinate cellular morphogenesis in the archaeon Haloferax volcanii biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Iain Duggin retweeted
Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea biorxiv.org/cgi/content/shor… #biorxiv_cellbio
Iain Duggin retweeted
Have you got your ticket to the AMR symposium yet?! If not, get it below!
👇👇👇
In partnership with @ASM_NSWACT, AIMI is hosting a Antimicrobial Resistance Symposium!
📆 21st November, 2024
📍 UTS, Ultimo NSW
📑 Abstract deadline: 10th Nov
🎟️ Registration deadline: 10th Nov
🔗 bit.ly/AMRSymposium2024
Iain Duggin retweeted
New paper online @PNASNews! Great collab with @Vikram_Alva, @PohlschroderLab, @SchmidLab and inspiring team work within the Bisson lab.
PNAS: shorturl.at/tzNqn
Preprint: shorturl.at/Wi58N
Blurb: shorturl.at/vMZsZ
highlights below (1/4)
Iain Duggin retweeted
Excited to share our latest work. We developed a modified TraDIS appropriate for host cell infections where bacterial yields are limiting and applied it to a stage-resolved human bladder culture model of UTI @AIMI_UTS
journals.asm.org/doi/full/10…
Beyond bacterial paradigms: uncovering the functional significance and first biogenesis machinery of archaeal lipoproteins biorxiv.org/content/10.1101/…
Iain Duggin retweeted
Min system proteins are known for their role in positioning of FtsZ, a #tubulin homologue, in bacteria.
In the latest preprint from myself and @iduggin we find for the first time that min proteins spatially regulate CetZ tubulin homologues in #archaea
MinD proteins regulate CetZ1 localisation in Haloferax volcanii biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Archaeal MinD proteins showing their colours, as seen by @hannjbrown. Pushing CetZ1 cytoskeletal proteins around.
MinD proteins regulate CetZ1 localisation in Haloferax volcanii biorxiv.org/cgi/content/shor… #biorxiv_micrbio
More evidence against them in the accompanying preprint from @Archaellum and co!
biorxiv.org/content/10.1101/…
Iain Duggin retweeted
Cell division protein A (CdpA) assembles and anchors the two FtsZ rings at midcell in haloarchaea biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Iain Duggin retweeted
EXCITED to announce the preprint of our work on a NEW Cell division protein (CdpA) in FtsZ-based division system in Haloarchaea. Thanks for the collaborative efforts of our amazing team. @vinayaa_shinde Dalong Hu, Zhuang Xu, @BillSoderstrom @kmichie13 @iduggin @AIMI_UTS
Cell division protein A (CdpA) assembles and anchors the two FtsZ rings at midcell in haloarchaea biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Iain Duggin retweeted
Inspired by @iduggin and @S_Ithurbide (see their paper: bit.ly/45OAzIk), we decided to test different FPs in our lab (and new ones) by expressing FtsZ1 fusions in the ∆ftsZ1 background and observe cell morphology (funcionality_, brightness and photostability [2/5]
CetZ1-dependent assembly and positioning of the motility machinery in haloarchaea biorxiv.org/content/10.1101/…
Iain Duggin retweeted
Our last study from the @iduggin lab on improving tools to study haloarchaea as well as investigating the impact of linkers and various FP on fusion functionnalities is now published open acces @MicrobioSoc go.shr.lc/3WVR2If - 🔬🌈🦠
Iain Duggin retweeted
13 PhD positions available in a European consortium working on the biotechnological potential of Archaea! Please spread the word!
#positions #PhDposition
1 position in my lab. Apply here until the 12th of May!
archaeaforbiotechnology.eu/e…
Iain Duggin retweeted
This work started all the way back in my honours year in 2018. Excited to see the preprint out in the world!
We show that CetZs can promote cell motility by facilitating the assembly and positioning of motility machinery.
biorxiv.org/content/10.1101/…
CetZ1-dependent assembly and positioning of the motility machinery in haloarchaea biorxiv.org/content/10.1101/…