@ibracham_

Assistant Professor of Radiation Oncology • Harvard Medical School | Director of Clinical Outcome Modeling Lab • Mass General Brigham

 Boston, MA
connects.catalyst.harvard.edu/Profiles/display/Person/189242
Joined June 2013
  • Tweets1.6K
  • Following835
  • Followers914
491Media
Drugs can barely penetrate GBMs. We built a nanomotor that crosses the BBB, senses the tumor, and swims toward it, powered by hydrogen peroxide, which GBM produces in excess. 3x deeper penetration. 4.3x more potent. Out now in @MacroBioscience onlinelibrary.wiley.com/doi/…

Ferritin‐Based Nanomotors for Deep Glioblastoma Penetration and Enhanced Drug Delivery

We report an oxygen-propelled nanomotor composed of human heavy-chain ferritin nanocage (HFn) and catalytic CeO2 nanoparticles to enhance tumor penetration and therapeutic efficacy. HFn efficiently...

onlinelibrary.wiley.com
1
2
7
338
Ibrahim Chamseddine, PhD retweeted
Ibrahim Abu-Gheida@IAbuGheidaMDSep 28
More from Day3 @ASTRO_org #ASTRO26 @SJFrankMD @ACKoongMDPhD @ZeidanMd @RamiaPaul @ibracham_ @CancerConnector @CShahMD
2
15
608
Our new @IJROBP paper: proton RBE in lung exceeds the planning assumption of 1.1. Prospective breast cancer patients with serial CT at 6 and 12 months. Voxel-wise density change at matched physical dose. Measured RBE 1.24–1.35. sciencedirect.com/science/ar…
3
3
1
27
3,741
Happy to share that OncoRAG is out at @Nature_NPJ Digital Medicine❗️ Pulling variables from clinical notes usually means manual chart abstraction or shipping notes to a cloud LLMs. Using graph retrieval, OncoRAG enabled local models to match LLM accuracy nature.com/articles/s41746-0…

OncoRAG: graph-based retrieval enabling clinical phenotyping from oncology notes using local...

npj Digital Medicine - OncoRAG: graph-based retrieval enabling clinical phenotyping from oncology notes using local mid-size language models

nature.com
3
1
14
1,122
Please apply before the end of the month if you’re interested. Applications links is comments.
Ibrahim Chamseddine, PhD@ibracham_Aug 12
Hiring 2 postdocs to work with @JanPOSchuemann and me at @MassGenBrigham @harvardmed on radiation + immunotherapy: 1.Multi-Scale Tumor–Immune Digital Twins 2.Clinical AI & Treatment Planning Software Deadline Aug 31, rolling review. Link for applications in comments
1
12
1,673
Hiring 2 postdocs to work with @JanPOSchuemann and me at @MassGenBrigham @harvardmed on radiation + immunotherapy: 1.Multi-Scale Tumor–Immune Digital Twins 2.Clinical AI & Treatment Planning Software Deadline Aug 31, rolling review. Link for applications in comments
2
2
1
9
2,413
1. radoncphysics.massgeneralbri… 2. radoncphysics.massgeneralbri…
177
Happy to introduce *RN-D3*: an AI pipeline for detection, differentiation, and delineation of radiation necrosis on 🧠 MRI. Out today in @FrontiersIn AI. All credit to @pgsalome3, who drove this, and to all co-authors Paper: doi.org/10.3389/frai.2026.18… Code: github.com/chamseddine-lab/r…
4
10
618
2nd Physics Research Retreat at in @MGBResearchNews Rad Onc. A lot of exciting work across the division. From our group: mechanistic modeling of 🧠 necrosis @nicogno_ , LLM-based future extraction @pgsalome3, and causal ML to identify drivers of proton therapy. Papers soon❗️
1
8
265
Welcome Yejin and Francois!
Brian Winey, PhD DABR@brianmedphysMar 30
The @HarvardMedPhys Residency Program is excited to welcome: -Dr. Yejin Kim, postdoctoral scholar at the University of Washington -Dr. François de Kermenguy, postdoctoral scholar at Harvard Medical School and BWH/DFCI Congratulations! #medphysmatch
1
242
Ibrahim Chamseddine, PhD retweeted
OncoDaily
@oncodailyMar 8
Pediatric Cancer Research Foundation - Recognizing 2026 Grant Recipients Advancing Childhood Cancer Research @PCRF_Kids @LevGorfinkel @RRonsley @ibracham_ oncodaily.com/voices/pediatr… #OncoDaily #Oncology #Cancer #Health #Medicine #MedX
2
4
176
Ibrahim Chamseddine, PhD retweeted
Jeffrey West
@mathoncbroMar 3
Re: use of LLMs for scientific writing Science is still partially reputation-driven, and anything with your name on it will be tied to you for the remainder of your career. Discernment and responsible use are required!
2
2
19
1,779
Ibrahim Chamseddine, PhD retweeted
Jeffrey West
@mathoncbroFeb 19
This week in MathOnco 360: Clonal hematopoiesis, predictive modeling, agent-based models, adaptive therapy Art: @nicogno_, @ibracham_ 😎🥇 thisweekmathonco.substack.co…
3
1
16
955
Ibrahim Chamseddine, PhD retweeted
Henning Willers, MD, FASTRO
@HenningWillersJan 15
📢The February issue of the #RedJournal is out and it has soooo much great #radbio in it🔥🔥🔥 Where to begin❓ Highly timely review: Radiation-Induced Lymphopenia: From Mathematical Modeling Toward Mechanistic Learning ‼️ ⚠️OPEN ACCESS redjournal.org/article/S0360… With accompanying commentary by @CGrassberger & Team🙏🙏🙏 ⚠️redjournal.org/article/S0360…
11
27
2,891
Very pleased to receive the Translational Research Grant from the Pediatric Cancer Research Foundation @PCRF_Kids For many children treated for brain cancer, survival comes with lasting hearing loss. This work aims to better predict that risk and support treatment decisions that protect long-term function. Thanks for PCRF and for the great collaborators who made this possible: Drs. Torunn Yock, Harald Paganetti and David Grosshans @MGBResearchNews, @MDAndersonNews #PediatricCancer #Survivorship #RadiationOncology
1
2
4
205
🚨 New paper in @IJROBP We used 🧠MRI, synthetic vascular maps, and a 3D cellular automata 💻 to predict how radiation necrosis spreads and which voxels are at highest risk on follow-up. Huge shout-out to @nicogno_ and all co-authors. 🔔This is my first time as last author in the Red Journal 😌 DOI: 10.1016/j.ijrobp.2025.09.059 🏛️@MGBResearchNews + @HarvardRadOnc + @UF + @MDAndersonNews + @ChariteBerlin #RadOnc #MedPhys #MedicalPhysics #ProtonTherapy #NeuroOncology #BrainMRI #BrainTumor #CNS #ComputationalOncology #MathCancer #DigitalTwin #RadiationToxicity
3
7
441
Ibrahim Chamseddine, PhD retweeted
Felix Ehret@FelixEhretMD11 Oct 2025
Excited to share our latest @IJROBP paper on modeling brain necrosis progression based on vascular heterogeneity! Huge congrats to the team for this accomplishment! @nicogno_ @ibracham_ @keyurmedphys @ASTRO_org @ESTRO_RT @HarvardMedPhys @HarvardRadOnc redjournal.org/article/S0360…

A Mechanistic Model of Brain Necrosis Progression Based on Vascular Heterogeneity

Brain radionecrosis (RN) is a significant late toxicity of radiation therapy, yet its progression remains challenging to predict because of patient-specific factors. This study develops a mechanistic...

redjournal.org
2
8
20
2,166
Two @IJROBP acceptances in 1 week 🙃. Research is tough but weeks like this make it feel worth it! Huge thanks to @keyurmedphys and @nicogno_ who are the real engines behind these projects. Collaboration > everything
3
3
23
1,568
Today we had our 3rd @MassGenBrigham #RadOnc Research Retreat, organized by @MiyamotoDavid & Atchar Sudhyadhom & an able organizing committee👏👏👏 ☑️Inspiring intro & vision by @DAVIDPRYANMD MGBCI President ☑️Cutting edge interdisciplinary team science throughout the day🤝 ☑️Birthday surprises courtesy of our people's leader Daphne Haas-Kogan🥳 ☑️And much more😊 It is no secret we need to focus on The Mission‼️
4
17
2,042
Tomorrow at 3:30 pm Beirut time, I’m excited to be giving a keynote at @AUBMC_Official @AUB_Lebanon during the GARN-CLS 5th International Bioinformatics Workshop: Leveraging Artificial Intelligence and Big Data for Precision Medicine. Talk title: “Strategizing Next Generation Radiation Oncology through AI.” In my talk, I’ll present new AI methods to personalize proton and photon therapy and discuss how these approaches can be combined with immunotherapy to improve outcomes. #AI #Oncology #PrecisionMedicine #CancerResearch
5
310
Load more