@hlcao

microbial genomics and evolution, antibiotic resistance, bioinformatics, Pseudomonas aeruginosa, pneumococcus, human microbioa, @hkuniversity

 Hong Kong
Joined May 2011
  • Tweets5.3K
  • Following2.9K
  • Followers3K
Death and chemotaxis: Bacterial chemotaxis enables collective escape from phage predation science.org/doi/10.1126/scia…

Death and chemotaxis: Bacterial chemotaxis enables collective escape from phage predation

Bacteriophages (“phage”) are viruses that prey on bacteria in diverse environments, from biological tissues to soils. In many of these environments, bacterial hosts are constantly migrating, yet how...

science.org
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Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived antibiotic to enable growth in the gut science.org/doi/10.1126/scis…

Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived...

A coordinated response to low iron and bacitracin enables Clostridioides difficile to survive in the gut.

science.org
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From code to cure: Harnessing AI for antibiotic discovery and design science.org/doi/10.1126/scit…

From code to cure: Harnessing AI for antibiotic discovery and design

AI is accelerating antibiotic discovery, but clinical translation requires standardized data, safety optimization, and new regulatory frameworks.

science.org
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Microscale spatial fragmentation promotes bacterial survival under antibiotics nature.com/articles/s41467-0…

Microscale spatial fragmentation promotes bacterial survival under antibiotics

Nature Communications - This study reveals that microscale habitat fragmentation can protect bacteria from antibiotics. In tiny droplets, confinement slows growth and limits the antibiotic...

nature.com
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A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice nature.com/articles/s41586-0…

A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice

Nature - The administration of Bacteroides uniformis in mice can mitigate atherosclerosis via pentadecanoic acid, which directly inhibits HMG-CoA reductase to promote hepatic cholesterol clearance.

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NucleicBERT interprets RNA sequence space through self-supervised language modelling nature.com/articles/s42256-0…

NucleicBERT interprets RNA sequence space through self-supervised language modelling

Nature Machine Intelligence - RNA structure and function are hard to infer because annotations are scarce, despite abundant sequence data. Upadhyay et al. trained a self-supervised model on...

nature.com
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Resistance indicators in sewage microbiota mirror clinical antibiotic use with temporal lag linked to host nature.com/articles/s41467-0…

Resistance indicators in sewage microbiota mirror clinical antibiotic use with temporal lag linked...

Nature Communications - Profiles of antibiotic resistance genes in wastewater still often lack epidemiological context. In this study, the authors use wastewater metagenomics and antibiotic use...

nature.com
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Predicting genome-wide functional constraints with GPN-Star nature.com/articles/s41586-0…

Predicting genome-wide functional constraints with GPN-Star

Nature - GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction...

nature.com
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Prehistoric global migration of vanishing gut microbes with humans nature.com/articles/s41586-0…

Prehistoric global migration of vanishing gut microbes with humans

Nature - Microbial species disappearing from industrialized populations have evolved with humans over millennia and migrated worldwide with them—this may have consequences for human health.

nature.com
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Structural basis for regulating lipopolysaccharide transmembrane transport nature.com/articles/s41586-0…

Structural basis for regulating lipopolysaccharide transmembrane transport

Nature - Structures of the protein machinery in Gram-negative bacteria that transports lipopolysaccharide (LPS) from the cytoplasmic membrane to the outer leaflet of the outer membrane reveal how...

nature.com
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A hidden archaeal lineage with an ultra-reduced genome retaining only its replicative core cell.com/current-biology/abs…

A hidden archaeal lineage with an ultra-reduced genome retaining only its replicative core

Harada et al. describe an archaeon, recovered from a single marine plankton cell, whose 238-kb genome is the smallest known for the domain. It has lost nearly all metabolism but keeps the machinery...

cell.com
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Cryo-EM structure of a methanogen nitrogenase–PII protein supercomplex nature.com/articles/s41586-0…

Cryo-EM structure of a methanogen nitrogenase–PII protein supercomplex

Nature - Cryo-electron microscopy of a nitrogenase supercomplex from a methane-producing archaeon reveals a mechanism in which PII proteins drive assembly of such structures to regulate nitrogenase...

nature.com
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Ecological memory of prolonged plasmid persistence after transient antibiotic exposure nature.com/articles/s41467-0…

Ecological memory of prolonged plasmid persistence after transient antibiotic exposure

Nature Communications - Zhou, Weiss and colleagues show that a brief antibiotic pulse can prolong plasmid persistence by removing plasmid-free competitors, creating an ecological memory that may...

nature.com
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Within-host evolution and transmission of a human gut symbiont across ecological scales cell.com/cell-host-microbe/a…

Within-host evolution and transmission of a human gut symbiont across ecological scales

Vasquez et al. use high-resolution lineage tracking to follow tens of thousands of Bacteroides thetaiotaomicron lineages in the mouse gut. They show that rapid evolution can overcome colonization...

cell.com
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Hyperosmotic niche adaptation and tissue polyamines underlie MRSA persistence in the kidney science.org/doi/10.1126/scit…

Hyperosmotic niche adaptation and tissue polyamines underlie MRSA persistence in the kidney

Host polyamines and osmotic stress shape MRSA adaptation in the renal inner medulla.

science.org
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Genome mining of the tumor microbiome reveals biosynthetic diversity and potential pathology-modulating metabolites nature.com/articles/s41467-0…

Genome mining of the tumor microbiome reveals biosynthetic diversity and potential pathology-modu...

Nature Communications - Here, Pulliam and colleagues characterize the metabolites encoded by tumor-inhabiting microbes and their potential role in cancer pathology.

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A rapid, inexpensive diagnostic for bacterial pathogen and resistance detection in resource-limited settings science.org/doi/10.1126/scia…

A rapid, inexpensive diagnostic for bacterial pathogen and resistance detection in resource-limited...

Antimicrobial resistance is a major global health threat, with disproportionate impact in regions with limited diagnostic infrastructure. To address this challenge, we developed BADLOCK (Bacterial...

science.org
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Huiluo Cao 曹慧荦 retweeted
Science Advances@ScienceAdvancesOct 2
BADLOCK is a “one-pot” diagnostic platform to detect bacterial pathogens and resistance genes. Learn more: scim.ag/4hDNt2b
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Synergy between Enterobacteriaceae and diet mediates competition between dominant Bacteroidales in the human gut nature.com/articles/s41564-0…

Synergy between Enterobacteriaceae and diet mediates competition between dominant Bacteroidales in...

Nature Microbiology - Multiomic experiments using defined and native gut communities reveal that complex dietary glycans mediate the dominance of Prevotellaceae in non-industrialized gut...

nature.com
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Phage proteases activate CBASS antiphage immunity science.org/doi/10.1126/scie…

Phage proteases activate CBASS antiphage immunity

Cyclic oligonucleotide–based antiphage signaling systems (CBASS) are bacterial immune pathways evolutionarily related to cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) in humans....

science.org
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