85 year Harvard study following 700+ people found the #1 predictor of long-term health and happiness wasn't food, wealth or genetics. It was the quality of their relationships. Connection really is the cure for what ails you. Loving relationships = Good medicine.
'Take care of your body. It’s the only place you have to live.' – Jim Rohn. Let's get @healthy, baby!
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A Gut Metabolite Urolithin A Reduces Senescence and Inflammation.
Pomegranates, blackberries, and almonds all contain ellagitannins - a group of compounds that are converted to 'Urolithin A' (a postbiotic) by our gut bacteria and is shown to increase muscle mass and robust mitochondrial function and promotes brain health - all of which tend to decline as we age.
Now we know with this latest research that urolithin A also reduces senescent cells and inflammation.
lifespan.io/news/a-gut-metab… @LifespanIO
What do you want? Most people with a New Year's Resolution had goals falling into these six categories:
1. Save more money (21%)
2. Eat healthier (19%)
3. Exercise more (17%)
4. Lose weight (15%)
5. Spend more time with family/friends (14%)
6. Quit smoking (9%)
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31% of people trust their doctor
Pathetic
Readers added context they thought people might want to know
According to the study cited in the image, trust in physicians and hospitals decreased by 31.4% from 71.5% in April 2020 to 40.1% in January 2024.
jamanetwork.com/journals/jaman…
Walking supports cardiovascular fitness, bone and muscle strength...better skin, mental, immune & joint health. Add 5000 steps per day to drop around 24 lbs over the year. One Healthy change can transform your life.
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Make America Healthy Again includes helping people with addiction. Last year, more than 100,000 people died in the U.S. from drug overdoses. We need to address this crisis and provide opportunities for recovery.
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The amount of protein you eat at your first meal strongly predicts the amount of calories you’ll consume the rest of the day.
More protein = fewer calories.
Why is no one talking about this?
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Looks like Caffeine, quite possibly the healthiest recreational drug that has ever been discovered. A 2013 meta-analysis of 36 studies with >million participants and found a U-shaped relationship between coffee intake and cardiovascular risk. The sweet spot was at 3 to 5 cups a day; people drinking that much coffee had about a 15% reduced risk for cardiovascular disease compared with nondrinkers.
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Omega-3s seem to have pharmacological potential similar to that of a drug, but a risk profile more akin to nutrient
Very powerful
For most people, 2g/day (EPA + DHA) increases their omega-3 index from 4% to 8%, which is associated with a 5-year increase in life expectancy
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This is a super important fact that I hope more to understand. Exercise is crucial for cognitive health. Thanks @foundmyfitness for sharing 🙏🏼
Aerobic exercise protects the brain from the age-related loss of myelin, which is crucial for efficient communication between neurons and maintaining cognitive clarity.
In a new study, higher fitness levels were strongly linked to better myelin integrity in the brain across nearly all of the brain regions studied, with those in poor fitness showing worse myelination.
This relationship was more robust in middle-aged and older adults, emphasizing the critical role of fitness in preserving brain health as we age.
Additionally, people with higher fitness levels, as indicated by a higher VO2 max, experienced slower myelin degradation, with the highest VO2 max linked to a peak in myelination around age 41. In contrast, those with a low VO2 max showed rapid demyelination, with their myelin levels peaking before age 22.
While this study shows an association, not causation, the broader evidence supports the idea that improving fitness can enhance overall brain health.
The best way to improve fitness? Exercise, particularly high-intensity interval training or HIIT. We know it’s good for the body, and accumulating evidence suggests that it’s indispensable for brain health too.
PMID: 39159379
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Going from zero physical activity to just 20 minutes a day leads to a 3 YEAR GAIN in life expectancy and this could be facilitated by changing the design of streets so they are walkable and bikeable.
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Rejuvenation Olympics has become a thing. @WSJ covering it today.
Don't Die is a now a professional sport, complete with points and a leaderboard. I started RO last year because people didn't know how to categorize my endeavor.
For contrast, when LeBron James sleeps and eats well, people respect the discipline and court performance. When I do something similar, I get vilified.
Not knowing what category to put me in their minds, people have been filling that void with some kind of derogatory frame such as "tech bro, biohacker, and Patrick Bateman".
In their reporting, the WSJ even did this saying "In this contest founded by tech entrepreneur and longevity bro Bryan Johnson, anti-agers take their health obsession to new levels." It's an odd thing that working hard towards health warrants a dis.
I started RO for a few reasons. First, in health and wellness, it's very hard to know who to trust. Everyone disagrees with everyone about everything. So what does one do?
One way to make systemic progress in health is to rely more upon measurement and data. Less upon human opinion. Data is not perfect but it can often be a helpful language, signal, bridge and stabilizer.
This is why I openly share my data and why I've become the most measured person in history.
Second, I started RO to highlight others' success and so that they in turn can give back to the community, sharing what they've learned and what they're doing.
Whether you're trying to be a bit more healthy or beat me on the leaderboard, I'm here to help you. I'm currently helping several people right now who are trying to beat me and I hope they do. That would be a great sign of progress.
The goal is accelerating progress in longevity by open sourcing methods and helping everyone out. Lending a hand to the majority of people who do not have access to skilled rejuvenation doctors or don’t have the time to dedicate themselves to learning.
Remember that this leaderboard uses speed of aging which is just one biomarker. There are dozens more biomarkers that are just as important. Join in on the fun. Don’t Die is a team sport.
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Magnesium to the Rescue for Metabolic Syndrome!
Metabolic Syndrome essentially means that you have a a cluster of health conditions (1/3 of Americans have it and few people realize they have it) such as:
Excess abdominal fat
High blood pressure
Impaired fasting blood sugar
Low HDL ("good") cholesterol
High triglyceride levels
BUT the good news? Research shows that oral intake of magnesium may be a helpful tool in managing the conditions that make up metabolic syndrome:
In human studies, magnesium intake:
-Improves blood sugar levels and insulin resistance (!)
-Reduces elevated blood pressure
-Lowers markers of inflammation
-Reduces triglycerides
-Improves cholesterol levels
Generally, magnesium glycinate is an all-around very absorbable form of magnesium. Stay away from magnesium oxide unless you are constipated.
Research:
Piuri G, Zocchi M, Della Porta M, et al. Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Nutrients. 2021 Jan 22;13(2).
Castro AM, Macedo-de la Concha LE, Pantoja-Meléndez CA. Low-grade inflammation and its relation to obesity and chronic degenerative diseases. Revista Médica del Hospital General de México. 2017 2017/04/01/;80(2):101-5.
Verma H, Garg R. Effect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta-analysis. J Hum Nutr Diet. 2017 Oct;30(5):621-33.
Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016 Aug;68(2):324-33.
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Interestingly, research has shown supplementing with the combination of Glycine & N-Acetyl Cysteine (NAC) can help improve key markers of aging.
Improves mitochondrial function, DNA damage, insulin resistance, inflammation & several key aging markers along with muscle strength, cognition, & more!
With NAC and glycine being building blocks of glutathione, it’s not surprising that this combination improved and reversed multiple age-associated abnormalities including mitochondrial health, blood pressure, waist circumference and telomere health.
ncbi.nlm.nih.gov/pmc/article…
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Vitamin D deficiency impairs the conversion of tryptophan into serotonin
Serotonin is essential for:
• Mood
• Executive function
• Long-term planning
• And impulse control
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Do you know the theory behind why restaurants give you bread before a meal?
Source: @joeroganhq



















