
Co-Founder & CEO @steadymd
St. Louis, MO
Joined June 2009
- Tweets11.6K
- Following1.5K
- Followers1.3K
- Likes638
Guy Friedman retweeted
What is different this time is the percentage of venture dollars going into a small number of companies by an even smaller number of venture firms. This concentration of capital is unprecedented.
So where does this leave the rest of the industry with a smaller quantum of dollars but a larger n of firms? Feeling squeezed at both ends. The cost of entry in the consensus companies is beyond reach while the access to capital to support non-consensus businesses is sharply constrained.
Only the strong, the visionary and those with unwavering conviction in the non consensus will survive this super cycle. Thousands of firms will be the walking dead, while a small set will survive and emerge from the ashes of the inevitable washout even stronger.
So which group are you in? Unless you know you’ve got what it takes to win and can sell this vision to LPs and founders alike, you’re toast.
Welcome to early stage non-consensus venture investing c.2026.
@gamechangersvc
Pricing in venture is wilder than ever.
$100M pre-seed is now normal.
Bessemer just raised $1.75BN for “early” and $4BN for growth.
So can you even do seed today without $1BN?
- Is capital truly one of the last remaining moats?
- Do all small seed funds and mid-sized firms just fade into irrelevance?
- Does entry price matter anymore when there are $TRN companies…
- Is this real or a bubble that is about to burst
I sat down with @spdholakia to discuss this and have added my notes from the discussion below.
1. This Is a Supercycle Like Never Before
Sameer has spent 31 years in software and has felt magic only a handful of times. A trillion-dollar supercycle followed every one of those moments, and he notes that it does not happen very often.
What is different and what is similar to prior cycles @altcap @infoarbitrage
2. Capital Is a Moat Today
Markets pick winners and the choice becomes a self-fulfilling prophecy, as it did when developers settled on SendGrid and Twilio. In legal AI, big law firms name just two major providers. Capital lets leaders scale at an extraordinary pace and build a brand, which draws talent and customers in a reinforcing flywheel.
Do you agree with this @venkyganesan @dafrankel
3. Who Wins and Who Loses in the Future of Venture Capital?
As industries professionalize, firms must be either a giant global platform that consolidates or an extreme specialist, such as an early-stage AI investor in San Francisco. Sameer counts Bessemer as a big global platform. Firms caught in between face a hard world to make money.
Is it go big or go home @rodriscoll @rabois @chetanp
4. The Rationale for Why Anthropic Would Compete With the Hyperscalers and Why We Invested
As in the cloud era, AI would be massively capital intensive, so it would consolidate to a handful of players with hundreds of apps on top. Microsoft had partnered with OpenAI and Google was building Gemini, while AWS had an undistinctive internal model and had just invested heavily in Anthropic.
5. Why Price Does Not Matter in a World of AI and the Metric That Truly Determines Value
Bessemer invested in Abridge at $5M of ARR for a $700M to $800M valuation, in Anthropic at roughly 150 times current ARR, and led Legora's $1.8B round at $20M of ARR. Sameer judges these deals on what the company can become in the next twelve months.
How has your relationship to price changed in a world of AI @mignano @mmurph
6. Why the Rise of Open Models Does Not Denigrate the Market for Closed Models
In a market this large, predicting the mix between closed and open tokens with any precision is irrelevant. Consumers, enterprises and governments will all want different flavors of intelligence. Bessemer has invested in both Anthropic and Fireworks to hold exposure to closed and open tokens.
Love to hear how you think about this @lqiao @bernhardsson
7. Why It Is a Permanent Structural Shift That Companies Will Stay Private for Longer, but Why It Will Open in 2028
With more dollars and more firms in private venture, companies will stay private longer, and most of the run-up in this boom will happen in private markets. Sameer still expects an unlock in IPOs later next year and in 2028.
Love to hear your thoughts on this @bgurley and how you see it evolving in 24 months?
(links in comments)
Guy Friedman retweeted
KYLIAN MBAPPE WHAT A GOAL !!!!! xitter.cf/alaskafreezys/status/2…
Guy Friedman retweeted
Missouri’s history is really unique. St. Louis was founded by the French, and had good relations with the natives. It became part of America through the Louisiana purchase. Americans settled along the Mississippi. Osage war bands attacked the settlements leading to a war, the result was to push the Osage west. (They later joined the confederates). Germans came into the new territory to farm and founded dozens of towns in the Ozark mountains. It means cities like St Louis have large influences from the French, the English and Germans. When it joined the Union it couldn’t decide if it was in the north or south. A new piece of legislation was created to solve this. Missouri remained straddling the line and during the civil war brother really did fight brother in Missouri. Militias joined both sides. Even geographically the state is split in two. The north is flat farmlands, the south is mountainous, filled with rivers and streams. It’s one of the most bio diverse places in North America. It has giant salamanders, bears and wildcats, even a native freshwater jellyfish.
Hard to believe strolling through Manhattan on a random Tuesday and every restaurant packed
BREAKING: The number of restaurants in New York dropped ~2,000 YoY in Q1 2026, posting its largest YoY decline in at least 36 years.
This surpasses even the worst contraction recorded in any quarter during the 2020 pandemic.
The number of eating and drinking places in New York State has now declined YoY for 4 consecutive quarters, its longest streak since 2021.
This comes as restaurants are facing surging operating expenses, including insurance premiums, wages, interest rates, utilities, and health coverage, with overall costs rising faster than national averages.
Last year, employee health insurance costs jumped +12.9% for New York-area service firms, business insurance rose +7.0%, while utility costs surged +8.5%, according to the Manhattan Chamber of Commerce.
Skyrocketing costs are crushing New York restaurants.
Guy Friedman retweeted
Interesting that almost every form of social activity has dropped over the last 30 years except going to concerts. That has increased and probably at a very high record level. Their value rose probably because the alternatives have weakened.
When will this effect Google/Amazon revenue in a meaningful way?
More than 1 in 3 Americans bought something based on an AI recommendation in the past year
44% say AI helps them find better value for money
34% would pay more for a product if AI showed it was the best option for them
Charts of the Week: a16z.news/p/this-week-in-cha…
Guy Friedman retweeted
6,000 years of world history on a single timeline. Zoom in. You could spend 30 minutes exploring this.
Very cool
inspired by @thomasforth 's population tool; tomforth.co.uk/circlepopulat…; i present gdp around a point: moneymap.jjpcodes.com/
if you dont have > $250bn within 30km you're ngmi.
Great data here
In @JAMA_current led by @vrpatel97, @IAmSamFin and @AnupamBJena: how are US 👨⚕️ actually using AI? We analyzed 271M queries from 950K+ clinicians on @OpenEvidence over 2.5 years. Monthly active users grew from 355 to 700K+, and 9/10 kept coming back.
Link: jamanetwork.com/journals/jam…
Actually great list
Most famous book tied to every U.S. state
🇺🇸 Alabama — To Kill a Mockingbird
🇺🇸 Alaska — The Call of the Wild
🇺🇸 Arizona — The Bean Trees
🇺🇸 Arkansas — Where the Red Fern Grows
🇺🇸 California — The Grapes of Wrath
🇺🇸 Colorado — The Shining
🇺🇸 Connecticut — The Ice Storm
🇺🇸 Delaware — no single flagship novel
🇺🇸 Florida — Their Eyes Were Watching God
🇺🇸 Georgia — Gone with the Wind
🇺🇸 Hawaii — Hawaii
🇺🇸 Idaho — Housekeeping
🇺🇸 Illinois — Native Son
🇺🇸 Indiana — The Magnificent Ambersons
🇺🇸 Iowa — The Bridges of Madison County
🇺🇸 Kansas — The Wonderful Wizard of Oz
🇺🇸 Kentucky — Beloved
🇺🇸 Louisiana — Interview with the Vampire
🇺🇸 Maine — Carrie
🇺🇸 Maryland — The Accidental Tourist
🇺🇸 Massachusetts — The Scarlet Letter
🇺🇸 Michigan — Middlesex
🇺🇸 Minnesota — Main Street
🇺🇸 Mississippi — The Sound and the Fury
🇺🇸 Missouri — Adventures of Huckleberry Finn
🇺🇸 Montana — A River Runs Through It
🇺🇸 Nebraska — My Ántonia
🇺🇸 Nevada — Fear and Loathing in Las Vegas
🇺🇸 New Hampshire — A Separate Peace
🇺🇸 New Jersey — The Great Gatsby (set on Long Island, linked to NJ)
🇺🇸 New Mexico — Bless Me, Ultima
🇺🇸 New York — The Great Gatsby
🇺🇸 North Carolina — Cold Mountain
🇺🇸 North Dakota — The Round House
🇺🇸 Ohio — Beloved (also linked to KY) / The Bluest Eye
🇺🇸 Oklahoma — The Grapes of Wrath (Dust Bowl)
🇺🇸 Oregon — One Flew Over the Cuckoo’s Nest
🇺🇸 Pennsylvania — The Lovely Bones
🇺🇸 Rhode Island — The House of the Seven Gables (nearby)
🇺🇸 South Carolina — The Secret Life of Bees
🇺🇸 South Dakota — Bury My Heart at Wounded Knee
🇺🇸 Tennessee — The Firm
🇺🇸 Texas — Lonesome Dove
🇺🇸 Utah — The Book of Mormon (religious text) / Riders of the Purple Sage
🇺🇸 Vermont — Ethan Frome
🇺🇸 Virginia — To Kill a Mockingbird (also AL) / Beloved
🇺🇸 Washington — The Absolutely True Diary of a Part-Time Indian
🇺🇸 West Virginia — The Glass Castle
🇺🇸 Wisconsin — Little House in the Big Woods
🇺🇸 Wyoming — The Virginian
U.S. overall — The Great Gatsby, To Kill a Mockingbird, and The Grapes of Wrath are the titles that travel farthest
Note: One book per state by setting, author birth, or the title people most often attach to the place. Not a sales ranking. Several books are claimed by more than one state (Grapes of Wrath for California and Oklahoma; Beloved for Kentucky and Ohio). Some states have no single dominant novel.
Source: Setting and literary association roundups; standard “books set in each state” lists
Interesting deal - will be curious to see where it ends up
Breaking News: Mayor Zohran Mamdani’s administration is making a $30 million investment to build a quantum research lab at New York University. In exchange, the city will receive 15% of any proceeds from intellectual property developed in that lab. nyti.ms/4jUe7GD
Guy Friedman retweeted
WashU invested $50 million in SpaceX about a decade ago and saw a more than $2 billion return after the company went public for the first time earlier this year. stltoday.com/news/local/educ…
Guy Friedman retweeted
I'm hiring my next Chief of Staff. You won’t know every field I work in. What matters is how quickly you learn, the questions you ask, and whether you can think from first principles. You’ll help evaluate opportunities and work with founders building consequential companies. Technical background preferred. Three-year commitment. Menlo Park, in person. Apply: jobs.ashbyhq.com/khoslaventu…
What do you think of this @mcuban ?
Introducing Prescription Marketplace, where patients and clinicians will be able to compare prices and pickup/delivery options from different pharmacies so they can make more informed decisions and save money.
A new API will introduce cash prices — what a pharmacy charges someone paying without insurance — alongside insurance-based prices. While clinicians can already see what a medication will cost under the patient’s insurance in Epic along with certain lower-cost alternatives, this opens up options that can be cheaper and more convenient for patients.
It also helps physicians keep their patients safe. Health systems will be notified when the patient fills their prescription and if a script goes unfilled for too long.
More information will be shared next week during Open@Epic.
Read more: prnewswire.com/news-releases…
Guy Friedman retweeted
WWDWWWWWDWDWDWDWWWWWD
#AllForCITY x @wwt_inc
Guy Friedman retweeted
I spent 48 hours in SF hanging out with billionaires, data labs and AI founders and execs running $1B to $100B companies.
My observations:
1. Sooo MANY stories of data brokers making like $2M a WEEK selling company data to labs. I can't tell if it's the beginning or a bubble, and I kept wondering which niches are left. Digging into it actively.
2. At dinner, someone asked the table, "If a new model drops next month, does your company get better or worse?" HALF the table went quiet! I think that's the best question to ask about any AI startup right now.
3. The bar people talk about now is hitting $1B in revenue in 12 months (I guess that's the new unicorn?). What I didn't hear much about is retention. AI revenue can come in fast and leave fast, and I think we're going to see a lot of stories of AI companies with huge revenue and terrible retention.
4. It's pretty clear we're living through the reinvention of the computer. The model is the CPU, the harness is the operating system, and skills and plugins are the apps. Thinking about it that way makes it easier to see where the whitespace is.
5. We're maybe 12 months from an agent that can watch you work for a week and then do your job without any instructions. The screen recording plus agent memory plus local model combination makes this possible right now.
6. Agent harnesses feel like the new GPT wrappers, in a good way, especially vertical ones. The best teams I talked to treat the model as swappable. One founder walked me through routing different models to different jobs: one for taste and visuals, a cheaper one for the everyday stuff, another for text.
They use prompts they can move across models over fine-tuning, and A/B test the output on what users actually do with it: do they edit it, export it, share it? A vertical harness is basically four things: the connectors for that industry's data, evals written by people who know the work, rules for what the agent can and can't touch, and a clean screen for a human to review. The model is maybe 20% of it.
7. There's a lot of reverse engineering going on/cloning going on more than I've ever seen. People are decompiling software and rebuilding it with agents, and someone showed a suite of like 10 apps that are worth $5B+ each all that he cloned open source. Me and everyone are still thinking through what it means when software gets this easy to copy.
8. My guess is the value moves to data. If the software can be rebuilt quickly, what's worth paying for in a legacy SaaS company is the years of customer data and workflows inside it. Some SaaS companies are secretly data companies.
Gets me thinking about how do you truly value data for this saas companies? Like if we were buying these dying saas companies at 2x ARR before (as example), maybe there is a better metric. Idk, just thinking out loud here.
9. It feels like a good chunk of legacy software won't make it to the agentic era, especially anything built around people clicking through a lot of screens.
10. Every company I talked to wants to pipe its internal data into one place and expose it to agents through MCP. Then they look at the data and realize it's a mess: five versions of the same customer, old Slack channels, PDFs nobody can search. Cleaning that up feels like a big consulting opportunity!
11. A lot of founders are building the basic building blocks for agents: APIs, data layers and tools. Some of the companies I saw barely have a UI because the main user is an agent. I really believe the startups that build primitives to this agentic era will do extremely well. Building blocks is the best way to think about it.
12. Labs can get plenty of training data, but it's harder to get real examples of agents failing inside companies. Whoever has those logs has something valuable.
13. Someone running a big consumer company told me the next fight is over memory. The model that remembers the most about you wins, and the smartest model matters less than people think.
14. Physical AI came up a lot. Astra I think was the first model that got people into AI can actually do CAD, and I think a lot of people are thinking what does vibe manufacturing really look like. The line I keep thinking about came from a robotics founder: the hardest problems in AI are deployment problems now, not research problems. Their robots work on their own, call a human when they get stuck, and every one of those calls becomes training data.
15. Cybersecurity companies are having a moment and are actually cool companies to build now, especially the ones that clean up after a breach. Every agent with access to your systems is a new door into your company, and a lot of those doors were left open.
16. Some startups are worth more dead than alive now. A shutdown company with 5 years of Slack, email and code can get paid for licensing all of it. I wouldn't be surprised if founders start factoring that into when they shut down.
17. People are starting to talk about monetizing the agent web. It feels really early, but when the most popular user of the internet is an agent, what startups should you be building?
18. I think agent insurance is coming. Once an agent makes an expensive mistake, insurers will want audits before they cover anyone.
19. Several people said the hire they want most is someone with taste who can write evals. The models are getting good at generating ideas, so the hard part is judging which ones are good.
20. New trend I observed: startup raises VC, uses venture dollars to become a creator, startup fails, founder falls back on being a full-time creator and incubates other products bootstrapped.
21. Getting SIGNIFICANT distribution is HARD right now. Founders are sponsoring buses, buying billboards like crazy and throwing parties with famous DJs to get noticed. Kinda feels dotcom era in that sense.
Attention is what's scarce! The growth guy going viral sharing his UGC strategy from Wispr Flow is a good example. It's the sauce everyone wants, and I truly believe there are probably only 50 people on the planet who know how to scale these types of businesses efficiently in this era.
Always good to get that dose of SF. I felt sooo lucky to have such an incredible trip during such an incredible time in building businesses. Surreal in so many ways.
Happy to be home and locked in.
Until next time!
Interesting ranking, esp the human capital part (why would SF be 37?)
Top 25 Cities in the World (2026)
1. New York
2. London
3. Paris
4. Seattle
5. San Francisco
6. Dublin
7. Boston
8. San Jose
9. Tokyo
10. Zurich
11. Oslo
12. Los Angeles
13. Sydney
14. Washington, D.C.
15. Stockholm
16. Melbourne
17. Dallas
18. Copenhagen
19. Munich
20. Toronto
21. Amsterdam
22. Berlin
23. Geneva
24. Vancouver
25. Brussels
Source: Oxford Economics, Global Cities Index 2026




































