@grvsadrian

PhD @casanova_lab, @InstitutImagine. @AgroParisTech, @UnivParisSaclay & @univ_paris_cite alumni. Auto-antibodies, viruses, innate immunity, IEIs🔬

 Paris, France
Joined June 2023
  • Tweets25
  • Following301
  • Followers157
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Grateful to have had the chance to present part of my work @ESIDsociety, with over 2,400 attendees! It was an amazing experience connecting with scientists from around the world and having insightful discussions. Can’t wait for the next edition!
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ESID@ESIDsociety17 Oct 2024
The Phenocopies of IEI session at #ESID2024 features experts Steve Holland, @anne_puel, @BenHalePhD, Aude Magerus, Sophie Hambleton, and @grvsadrian exploring how similar phenotypes emerge from different genetic causes. #IEI #ESID
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Sébastien Nisole@SEBNisole2 Oct 2024
Just published in @NatureComms! We show that Usutu virus is the only mosquito-borne flavivirus to resist ISG20-mediated inhibition, thanks to a unique domain in its 3'UTR that protects its genome from degradation. A project led by @JimZPhD at @IRIM_life. rdcu.be/dVMK1
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Jeremie Rosain@JRosain1 Oct 2024
1/ Excited to report in @JExpMed more about the causes and consequences of human autoantibodies neutralizing type I IFNs through the study of a rare disease: shorturl.at/cWcCa
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Eric Topol
@EricTopol23 Sep 2024
About 10% of people who develop severe Covid have autoantibodies to Type 1 interferon, which doesn't get diagnosed. Now there's a simple assay. It's also relevant for other life-threatening viral illnesses, and these Abs exist in ~100 million people worldwide. pnas.org/doi/epub/10.1073/pn… @PNASNews @grvsadrian @casanova_lab
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We report here in @PNASNews a simple assay to detect human type I interferon (IFN-I) deficiency. This test could revolutionize the diagnosis and management of patients with autoantibodies against IFN-I and inborn errors of immunity (IEI) affecting the IFN-I pathway!
Casanova Lab@casanova_lab25 Sep 2024
1/ We are excited to share a simple yet powerful whole blood assay to detect human type I interferon (IFN) deficiency...
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Thrilled to share my second first-author paper out in @JExpMed. We show that about 10% of severe tick-borne encephalitis cases are due to auto-Abs neutralizing type I IFNs. Thanks to all our wonderful collaborators!
Casanova Lab@casanova_lab25 Sep 2024
1/ We are excited to share our report in #JEM that about 10% of severe tick-borne encephalitis (TBE) cases, triggered by the TBE virus (TBEV), are due to pre-existing auto-Abs neutralizing type I IFNs (doi.org/10.1084/jem.20240637).
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🦟 5 cas d'infections à virus du Nil occidental ont désormais été rapportés dans le Var, et plus de 70 dans toute l'Europe (dont 8 décès). L'infection, par piqûre de moustique, est généralement asymptomatique mais elle peut provoquer de rares formes neurologiques graves. 1/3
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Judith Aberle@AberleJudith13 Aug 2024
West Nile virus season in full swing in Europe Austria reports 7 West Nile virus infections after mosquito bites (Lower Austria, Burgenland), including 3 hospitalized with neurological symptoms. One imported from Hungary Several others under investigation ecdc.europa.eu/en/news-event…

West Nile virus season in full swing in Europe

The expected seasonal increase of locally acquired West Nile virus (WNV) infections in Europe was observed as of July this year, indicating that the transmission season is well under way.

ecdc.europa.eu
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Casanova Lab@casanova_lab9 Jul 2024
The title tells it all ! Severe West Nile virus and Sars-CoV-2 infections in a patient with thymoma and anti-type I IFN antibodies pubmed.ncbi.nlm.nih.gov/3897…

Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient...

Patients with severe West Nile virus and SARS-CoV-2 infections deserve accurate diagnosis of underlying diseases, determining possible anti-interferon autoantibody production, since they must receive...

pubmed.ncbi.nlm.nih.gov
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I was delighted to share my work about West Nile virus encephalitis at the @Encephalitis2023 in London! And this is an honor to be awarded with the best platform presentation🙏 I met great people in with outstanding scientific level. Thank you Ava and the team! 🧠🧑‍🔬🤩
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#Encephalitis2023 is now underway. @encephalitisava & Dr Nick Davies are leading the first session. Speakers include Dr Tarun Dua @WHO , Dr Sophia Michael, Dr Christine Strippel, @grvsadrian & Dr Tina Damodar. Excited to hear what they have to say about #encephalitis research.
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👏🙏🚀
Casanova Lab@casanova_lab8 Nov 2023
1/ We are excited to report in @Nature the discovery that human inborn errors of the alternative NF-κB pathway-dependent immunity underlie the development of auto-Abs neutralizing type I IFNs (rdcu.be/dqBBU).
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I will have the great honor of presenting part of my PhD work at the @encephalitis 2023 meeting next December, in London. Thanks a lot for the amazing opportunity! 🤩
Encephalitis International@encephalitis21 Oct 2023
#WestNile virus #encephalitis will be the topic when @grvsadrian joins our panel of speakers at Encephalitis 2023. Our annual conference, aimed at medical professionals of all levels, can be attended @RCPVenue #London or online in December. Tickets 👇 bit.ly/3rZNTdm
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Screening for auto-Abs neutralizing type I IFNs is key to design prevention strategies. Check out doi.org/10.1038/d43978-023-0… @grvsadrian @BarzonLuisa @ShenYingZhang1 @casanova_lab @JExpMed

Un difetto autoimmune può rendere letale il virus del Nilo occidentale

Nature Italy - Quasi la metà dei pazienti infetti che sviluppano meningite o encefalite ha autoanticorpi che bloccano la risposta immunitaria, secondo uno studio.

nature.com
Mukesh@mkyindian18 Sep 2023
US: Officials call for precaution as first death due to West Nile Virus reported in New Jersey dhunt.in/PmFfY #WestNileVirus
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Félicitations à @casanova_lab pour leur nouvel article dans @JExpMed ! Après leur rôle dans les formes sévères de COVID et de grippe, ils éclairent le lien des autoanticorps avec les formes sévères d'encéphalites dues au Virus du Nil @Inserm @APHP @univ_paris_cite
Casanova Lab@casanova_lab22 Jun 2023
1/ We are excited to share our report in @JExpMed showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease (rupress.org/jem/article/220/…).
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One fantastic collaboration with @casanova_lab, @grvsadrian, @ShenYingZhang, and all the co-authors - just go through the thread to discover more !
Casanova Lab@casanova_lab22 Jun 2023
1/ We are excited to share our report in @JExpMed showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease (rupress.org/jem/article/220/…).
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Casanova Lab@casanova_lab22 Jun 2023
1/ We are excited to share our report in @JExpMed showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease (rupress.org/jem/article/220/…).
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Very happy to share my 1st paper as 1st author! Thanks to all our amazing collaborators for this fantastic journey. More to come! #WNV #autoAbs 🤩@esiborghe @casanova_lab
Journal of Experimental Medicine@JExpMed22 Jun 2023
.@grvsadrian et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ~40% of cases of West Nile virus (WNV) encephalitis. bit.ly/3qZIeDh @AurelieCobat @ShenYingZhang1 @casanova_lab @esiborghe #Autoimmunity #Immunodeficiency
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In @JExpMed, @grvsadrian et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ~40% of cases of West Nile virus (WNV) encephalitis. bit.ly/3qZIeDh @AurelieCobat @ShenYingZhang1 @casanova_lab @esiborghe
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