@fleig_s

nephrologist & clin. scientist; ultrasound enthousiast; vasc. biology&kidney disease; #FOAMed; 👩🏻‍⚕️👩🏻‍💻👩🏻‍🔬🔬🎻🏔️🏝️🚴‍♀️🏃🏻‍♀️views = own //🦋sfleig

 Aachen, Germany
Joined October 2018
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64Media
PAPER ALERT! :-) Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures - nature.com/articles/s41467-0… rdcu.be/cLIL1 out today in @NatureComms . Thank you to all coauthors!
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Cold-induced hypertension via sympathetic nerve activation 👇
Hypertension@HyperAHA3 Apr 2025
RESEARCH ARTICLE: Progressive Increase in Renal Sympathetic Nerve Activity Induced by Cold Exposure ahajrnls.org/3YgKt2J
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Emerging Scientist Award session with three finalists at #pcvb2025 in Frankfurt @SFB1531 - Tore Bleckwehl from @RWTH presenting on spatial transcriptomics in human atherosclerosis
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Next up Laetitia Préau from @lenoblelab on novel organotypical angiogenic cell types determining neural vascularization
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And Haaglim Cho from MPI Bad Nauheim on EC insulin resistance induced by adrenomedullin mediating obesity-associated diabetes
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Now online in @NDTsocial The evolving spectrum of kidney amyloidosis 🧐 Advances in diagnosis, typing and treatment ▶️academic.oup.com/ndt/article…
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Open call for abstract submission and applications for the GfMVB Emerging Scientist award and the Aletta Jacobs Award session at pcvb2025.de in Frankfurt, April 3-5, 2025! #vascularbiology #cardiovascular #EVBO #GfMVB
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Susanne Fleig retweeted
Konrad Hoeft@KonradHoeft18 Dec 2024
1/13) We are thrilled to share our new paper published in @NatureCommunications (shorturl.at/M5ie4) that systematically compares scRNA multiplexing methods and develops a new genetic multiplexing workflow SoupLadle.
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Susanne Fleig retweeted
Rainer Kaiser@kaisersohn12 Dec 2024
Thrilled to see the final version of our venous #thrombosis study on procoagulant platelets on the Cover of this week‘s @BloodJournal issue 🩸🫶 @nicolai_leo @LMU_Uniklinikum @dzhk_germany @EKFStiftung @dfg_public Props to our PhD student Maité, who took this beautiful image!
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In this editorial, the authors argue that a study by Winkelman et al. puts into question the traditional dietary recommendation to avoid whole grains in CKD and underscores the importance of diet quality in CKD, by pointing out the potential negative effects of plant-source UPFs on cardiovascular and kidney outcomes. bit.ly/CJASN0595 @fleig_s
Photo by Rachael Gorjestani on Unsplash.

ALT Photo by Rachael Gorjestani on Unsplash.

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Happy to share our new paper @NatureComms led by @KonradHoeft @BleckwehlTore @sikandhayat. Label-free single-cell RNA multiplexing leveraging genetic variability. nature.com/articles/s41467-0… 🔥🔥👇👇 Tweetorial will follow

Label-free single-cell RNA multiplexing leveraging genetic variability

Nature Communications - Here the authors establish and benchmark a single cell RNA multiplexing framework that enables simple, yet robust high-throughput multiplexing leveraging single cell...

nature.com
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Susanne Fleig retweeted
Lori O'Brien@l_obrien_lab20 Nov 2024
For all those interested in vascularizing organoids, check out this great paper from Maggiore et al on their inducible vascularized kidney organoid model and my accompanying commentary! kidney-international.org/art… kidney-international.org/art…
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Is Fast not Furious? In cohort studies reviewed by a giant in electrolyte research, rapid correction of severe hyponatremia is associated with better rather than worse outcome @MarcusSaemann @dgfn_ev @AKronbichler @hswapnil @Julie_Celine @nervensystemck jamanetwork.com/journals/jam…
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Patient Education: Creative Ways to Add Flavor to Meals Without the Salt by @windycityRD and ChatCPT jrnjournal.org/article/S1051… @MarcusSaemann @gregorymmarcus @BruceNeal1 @dgfn_ev @fleig_s @oegnephro @luisbeckdasilva @JustinEzekowitz
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Chronische Nierenkrankheit (#CKD) ist die 7. häufigste Todesursache bei #Frauen weltweit🌍. Eine neue Studie zeigt: Prävalenz um 2,10 % gestiegen📈, Sterblichkeit um 3,39 %. Besonders betroffen: Frauen ab 70. #Nierengesundheit #Prävention Link zur Studie: tinyurl.com/yn8ztyjn
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Susanne Fleig retweeted
Hao Yin
@HaoYin204 Nov 2024
Landmark revisit Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis Notch, a vessel-maturation signal, transcriptionally activates CPT1a & #FattyAcidOxidation during #EndothelialCell quiescence FAO-fed TCA cycle serves as a main source of NADPH (instead of ATP) in quiescent EC😁 EC CPT1a KO⏫LPS-induced endothelial ROS & inflammation Etoxomir CPT1i⏬EC barrier function @JoannaKalucka @CarmelietLab @Cell_Metabolism 2018 cell.com/cell-metabolism/ful…
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Very happy to have contributed to the review on intestinal lymphatics @NatRevGastroHep!
Nature Reviews Gastroenterology & Hepatology@NatRevGastroHep4 Nov 2024
New online! Transport functions of intestinal lymphatic vessels go.nature.com/3C8MA0i
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Limiting sugar before age 3 protects against diseases later in life science.org/doi/10.1126/scie…
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Awaiting @Dan_Fuster's interventional SWEET STONE trial: Here comes more epidemiological data that SGLT-2 may substantially lower the burden of nephrolithiasis - here studied in patients with prevalent stone disease @natalie_mccor @dgfn_ev @MarcusSaemann bmj.com/content/387/bmj-2024…
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Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient: Cell cell.com/cell/fulltext/S0092…

Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior...

Chemically induced stem-cell-derived islets were transplanted beneath the abdominal anterior rectus sheath in one patient with type 1 diabetes, resulting in tolerable safety and promising restoration...

cell.com
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Susanne Fleig retweeted
Hypertension@HyperAHA31 Oct 2024
A new prospective study finds that the angiogenic proteins sFlt-1 and PlGF may predict and improve the diagnostic accuracy for preterm preeclampsia among patients with CKD @placentaMD ahajrnls.org/4frX7Ck
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