Nootropics & neural grit :: Optimizing every variable :: #DARC

Joined September 2017
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The chip factory is basically a tortilla chip costume department
Doritos and Tostitos come off the same line. Both start as corn cooked in lime and water, soaked overnight and ground into masa. Frito-Lay sheets the masa between rollers and cuts it, triangles for Doritos and rounds for Tostitos, then fries it. A Frito-Lay manufacturing director has described it that way. The flavor isn't in the chip. It goes on after the fryer, tumbled onto the hot chip as a dry powder. On Nacho Cheese the list runs corn, vegetable oil, maltodextrin, salt, cheddar cheese, whey, monosodium glutamate, buttermilk, Romano cheese and on down, with Yellow 6, Yellow 5 and Red 40 for the orange. The cheddar and Romano are real cheese in powder form, and it's the MSG and the disodium inosinate and guanylate at the end of the list that make that small amount of cheese taste like a lot. The bag says nacho cheese flavored tortilla chips because FDA requires the word flavored when added flavor carries the taste. Take the seasoning off and what's left is a plain tortilla chip, made the same way as the one in the Tostitos bag.
Vitamin C and glucose compete for entry into cells, and glucose often wins. In tissue from the human small intestine, glucose cut vitamin C uptake by more than half. Other gut transporters that carry the oxidized form of vitamin C are blocked by glucose at very low concentrations. In both humans and mice, higher blood glucose went with less vitamin C inside red blood cells, and those cells were more fragile. This helps explain why people with chronically high blood sugar can run low on vitamin C even when they're well fed, and why scurvy still turns up in patients with obesity and diabetes. The evidence is clear that a person's vitamin C status depends on more than intake. The amount of glucose competing with it matters too.
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Repetition really can make a dumb thought sound reasonable after enough time
JUST IN🚨: Neuroscientists discovered something shocking: your brain doesn't care if your thoughts are true... it just believes whatever you think on repeat
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All-cause mortality by running distance and frequency The bare minimum gives you all and possibly more of the mortality benefit compared to much greater running volume and frequency. You simply don't need to exercise all the time for good health. jacc.org/doi/epdf/10.1016/j.…
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Replying to @rogersRussall
strength creates options. the more capable you become, the more choices you have when life gives you fewer of them
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Replying to @davidmobilenews
Xiaomi 18 Pro Max
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Mental wellness has broadened into "emotional fitness"—using structured journaling, somatic practices, and breathwork to build cognitive and emotional resilience.
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great reminder that more isn't always better, even with good stuff
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Faye 💅 retweeted
Naomi Osaka on her appreciation for Allen Iverson, who inspired her fit at the US Open 🔥
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Faye 💅 retweeted
Your gut does more than digest food. It shapes your immune system. It talks to your brain. It shows up in your skin. Most gut supplements use one or two types of fiber. Your colon actually has four sections, and each one needs its own. That is why I built LYMA ID² with four types of prebiotic fiber, one for each section. Link: lyma.sjv.io/gOQ545 Code: DAVE-10
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Replying to @jasonwilliamsmd
It’s hard not to get emotional watching this. We lost someone in our family to cancer and saw everything she had to go through. If losing one person is that painful, I can’t imagine what you’ve gone through losing multiple patients.
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We warned them: "Increased IgG4 synthesis due to repeated mRNA vaccination with high antigen concentrations may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals." mdpi.com/2076-393X/11/5/991?…
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Exercise and meditation don’t have to compete for your time. You can do both at once. Mindfulness can be practiced during physical activity, including vigorous aerobic exercise. That combination may be especially interesting because aerobic exercise is a powerful stimulus for neuroplasticity, increasing the brain’s capacity to change in response to experience. Pairing the neuroplastic effects of exercise with intentional mental training is an opportunity to cultivate awareness, connection, compassion, or other constructive states of mind. From the latest episode of the FoundMyFitness podcast with @RichieJDavidson.
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My brain scan explains why hate doesn’t bother me. I find it fun and easy. Here is what the data shows: + Amygdala 95th - emotion, threat detection + Putamen 99th - learning, habit formation + Caudate nucleus 97th - goal, decision, memory + Globus pallidus 93rd - movement control + Frontal gray matter 78th and still climbing How this might loosely map to what I do in life: > processing hate is an enjoyable activity for me > understanding it as information rather than threat > am a very fast learner > can maintain multiple threads in mind simultaneously > am a systems builder > can easily master habits > strong motor control Amygdala 95th percentile It’s the center of threat detection and emotional processing. The amygdala volume tracks the size and complexity of the social networks a person builds and maintains. Likely pointing to why my mind defaults to thinking about large social networks. Specifically, thinking about Don’t Die for all of intelligent life. Putamen 99th percentile This is brain infrastructure for learning. It turns repetition into skill, and skill into things you do without thinking. My daily protocol has hundreds of daily steps and none of them feel like effort anymore. Caudate nucleus 97th percentile Brain infrastructure for goal directed behavior, decision making and working memory. Makes sense given that daily I juggle being a founder, content creator, full-time rejuvenation athlete, and building the Immortals philosophy and movement. Pallidus 93rd percentile Brian infrastructure exercise. A good foundation for my attempt to dunk a basketball on a 10 foot rim. The above four regions are mostly hereditary. Twin studies put these structures at roughly 0.75 to 0.89 heritability, among the highest anywhere in the brain. If my brain is responding to what I'm doing day to day, it may be in my frontal gray matter. Adults who learned to juggle grew measurable gray matter within weeks. In a randomized trial, six months of aerobic exercise, three hours a week, grew the frontal cortex in people decades older than me. Brain structure follows use. My frontal gray matter sits at the 78th percentile and has been climbing steadily. It's up 1.35% over two years when it should be going down with age. This is the tissue of planning, self-control, and executive function. Inside the frontal lobe sits the anterior cingulate, also called the tenacity hub. It computes whether hard things are worth continuing. Superagers keep this region young. Mine has been getting stronger. Subjectively, that agrees with my life experience of how the level of work ethic required daily to maintain my rejuvenation athlete protocols plus two additional full-time jobs. This is of course speculative for my n of 1 context, yet the data strongly suggests it, and strong evidence backs it.
🤖 Made with AI
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Metabolic health benefits the most when insulin comes down the most. A new clinical trial tested three popular diets, and the diet that lowered insulin the most delivered the greatest metabolic payoff. Liver fat fell almost 50% more on the low-carb diet than on the others (low-fat plant-based and Mediterranean). The liver also became two to three times more insulin sensitive, produced less new fat from carbohydrate, and suppressed glucose production more effectively. Insulin across the day dropped far more with carbohydrate restriction, glucose fell more than twice as much, A1c improved the most, and prediabetes (i.e., insulin resistance) reversed at the highest rate. That is the beneficial biochemistry of a lower-insulin state. When insulin falls, the liver is no longer pushed to make and store fat. Lipogenesis slows, glucagon can tell the liver to oxidize fat instead, and the tissue becomes more responsive to the insulin that remains. The body becomes more insulin sensitive, and the liver can finally burn the fat it has been holding. Even though total weight loss was comparable across the three groups (by study design), lower insulin is what let the liver let go of the fat. cell.com/cell-metabolism/ful…
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Faye 💅 retweeted
Fried foods are taking years off your life. I know they are delicious, but they aren't serving your body. I've developed a full Bulletproof Fasting Challenge to help guide you through adopting better nutrition habits.
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The FDA approved daraxonrasib for metastatic pancreatic cancer after one prior treatment. KRAS drives about 90% of these tumors. Blocking KRAS slows growth and lifts the immune suppression that KRAS creates, which is the half of the mechanism most people skip. RASolute 302 dosed the drug systemically, and that is where the toxicity came from. We inject KRAS inhibitors into the tumor along with CD40, and we see complete responses in stage IV pancreatic cancer.
Forbes
@ForbesAug 26
FDA Approves Pancreatic Cancer Drug That Could Double Survival Time go.forbes.com/pm5qvj
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Keytruda does roughly $35 billion a year and is projected toward $75 billion before the patent runs out around 2027 and 2028. Build a product that has to be given with Keytruda and generic pembrolizumab has a much harder time taking that market. Merck is extremely good at making money. I am not convinced they are as good at curing cancer.
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Faye 💅 retweeted
Two measles deaths in Pennsylvania What a tragedy A completely avoidable tragedy Measles vaccine is incredibly safe and highly effective at preventing measles This is MAHA...sadly..
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IV vitamin C for cancer patients has been used for decades with almost no standardization - I get tons of questions about it, like should it be combined with chemo, is it effective, etc. A recent 2018 review in Frontiers in Physiology broke down what the research actually shows, question by question. Here it is: frontiersin.org/journals/phy… and my breakdown below.
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