@eric_aird

Postdoctoral Researcher in the Corn lab at ETH Zurich. CRISPRing by weekday, skiing by weekend.

 Zurich, Switzerland
Joined April 2022
  • Tweets7
  • Following17
  • Followers30
Eric Aird retweeted
Jacob Corn@jcornlab
Mar 18
Proper organelle regulation during mitosis is a must, but how do membrane-less condensates like PML bodies behave during cell division? In work led by @eric_aird, we found the balance of speckled proteins SP110 & SP100 to be the key. doi.org/10.1038/s41556-026-0…
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Eric Aird retweeted
Jacob Corn@jcornlab
Mar 12
Many genome-editing tools work by cutting DNA - but the shape of the cut matters. Using #CRISPR screening, we show ERCC6L2 is specifically required to maintain #DNArepair fidelity at staggered DNA breaks, but not at blunt ends. nature.com/articles/s41467-0…
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Eric Aird retweeted
Jacob Corn@jcornlab
4 Apr 2024
Amazing postdoc Eric Aird asked how #CRISPR gRNAs & interferon regulate innate #immunity. He found a wild partnership that balances appropriate response w/ cell death. SP100 builds filaments that kill cells, and SP110 breaks them to keep things in line. biorxiv.org/content/10.1101/… 🧵

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Stimulation of the innate immune system by foreign RNA elicits a potent response against invading pathogens and can trigger cell death. The mechanisms by which cells balance a robust response with...

biorxiv.org
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Today in @bioRxiv, we describe Click Editors (CEs) which combine DNA-dependent DNA polymerases, HUH endonucleases and RNA-programmable nickases for versatile genome editing without double-strand breaks 🧬. A study co-led with @connorjtou. A 🧵 (1/14): biorxiv.org/content/10.1101/…

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

Genome editing technologies that install diverse edits can widely enable genetic studies and new therapeutics. Here we develop click editing, a genome writing platform that couples the advantageous...

biorxiv.org
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WORLD CRISPR DAY is back! We'd love for you to join us at @Synthego's amazing, virtual, free scientific symposium that brings together genome engineering scientists, clinicians, and thought leaders from around the world! Please register for free at worldcrisprday.com
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The @jcornlab reports on Recursive Editing, a way to drive high levels of #CRISPR-mediated precise genomic modification without manipulating cell factors or state. An accompanying easy-to-use software designs experiments to optimize target selection. biol.ethz.ch/en/news-and-eve…
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The latest #CRISPR-​based genome editing systems are safer for patients who will soon benefit from gene therapies, as @eric_aird explains in the latest #ZukunftsBlog @ETH_en @ETH_DBIOL #GenomeEditing ethz.ch/en/news-and-events/e…
Photo of scientist Eric Aird and the following quote: Next generation CRISPR technologies work like molecular taxis. They can be used to shuttle proteins that directly change the DNA code without the same deleterious consequences caused by molecular scissors. This reduces toxicity for cells and expands the range of treatable genetic diseases.

ALT Photo of scientist Eric Aird and the following quote: Next generation CRISPR technologies work like molecular taxis. They can be used to shuttle proteins that directly change the DNA code without the same deleterious consequences caused by molecular scissors. This reduces toxicity for cells and expands the range of treatable genetic diseases.

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