Metreleptin may do more than improve glycaemia in Werner syndrome: this case also reports improved hepatic steatosis in partial lipodystrophy. @jstage_ej pubmed.ncbi.nlm.nih.gov/4287… #LPoM #lipodystrophy

MDPL can mimic Werner syndrome—but the skin can help distinguish them. This case highlights POLD1-related lipodystrophy, telangiectasias and soft-tissue calcification. @WileyGlobal pubmed.ncbi.nlm.nih.gov/4288… #LPoM #lipodystrophy

Can progerin-driven ageing be switched on at will? New inducible hiPSC lines provide matched LMNA, progerin and GFP controls for precise cellular-ageing models. @ElsevierConnect pubmed.ncbi.nlm.nih.gov/4286… #LPoM #lipodystrophy

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Werner syndrome puts genome maintenance center stage: this review links WRN dysfunction, replication stress, telomere crises and cellular senescence in progeroid aging. pubmed.ncbi.nlm.nih.gov/4097… #LPoM #lipodystrophy @ResearchKarger

Progerin distorted dermal fibroblast nuclei in vivo, yet limited expression did not impair wound healing or hair regrowth — refining how we model progeria pathology. pubmed.ncbi.nlm.nih.gov/4282… #LPoM #lipodystrophy @ElsevierConnect

Why does skin fibrosis erase fat? Wnt-driven oxidative stress and lipid peroxidation caused dermal lipodystrophy in vivo; scavengers protected both fat and collagen architecture. pubmed.ncbi.nlm.nih.gov/4283… #LPoM #lipodystrophy @FEBSnews

A newborn with mandibuloacral dysplasia type B carried novel compound-heterozygous ZMPSTE24 variants—expanding the genetic and clinical map of this rare lipodystrophy. pubmed.ncbi.nlm.nih.gov/4283… #LPoM #lipodystrophy @FrontiersIn

Liraglutide in congenital generalized lipodystrophy: a small series found lower HbA1c and insulin needs after 12 weeks, but GI intolerance limited treatment. pubmed.ncbi.nlm.nih.gov/4284… #LPoM #lipodystrophy @FrontiersIn

Tirzepatide in partial lipodystrophy: this retrospective series found improvements in weight, HbA1c, triglycerides and insulin needs. A promising signal needing prospective confirmation. pubmed.ncbi.nlm.nih.gov/4186… #LPoM #lipodystrophy @JCEMed

A case opening a new avenue: tirzepatide markedly improved glycemia and fatty liver, allowing insulin withdrawal in acquired partial lipodystrophy after HSCT. pubmed.ncbi.nlm.nih.gov/4242… #LPoM #lipodystrophy @FrontiersIn

When lipodystrophy meets fulminant type 1 diabetes: this case suggests persistent T-cell activation may drive insulin resistance beyond leptin deficiency. pubmed.ncbi.nlm.nih.gov/4280… #LPoM #lipodystrophy @Endocrine_J

Vesicles against vascular aging: melatonin-preconditioned MSC exosomes deliver miRNAs that attenuate progerin and PrPC in progeria models. pubmed.ncbi.nlm.nih.gov/4281… #LPoM #lipodystrophy @ElsevierConnect

Can antisense tackle dyslipidemia? Gapmers recruit RNase H to degrade target mRNA — an approach with therapeutic potential for lipodystrophy. pubmed.ncbi.nlm.nih.gov/4281… #LPoM #lipodystrophy @SpringerNature

Can progerin be disarmed without targeting the mutation itself? 🧬 FATE base editing disrupts the LMNA farnesylation site and rescues key HGPS phenotypes in neuromuscular organoids. @NatureComms pubmed.ncbi.nlm.nih.gov/4281… #LPoM #lipodystrophy

Same LMNA variant, different timing. Two siblings homozygous for p.Arg527Cys show delayed onset but severe generalized lipodystrophy, expanding the phenotype of mandibuloacral dysplasia. @WileyGlobal pubmed.ncbi.nlm.nih.gov/4276… #LPoM #lipodystrophy

How broadly can tirzepatide findings in partial lipodystrophy be generalized? Akinci & Oral question the heterogeneous “FPLD1-like” subgroup and urge caution in interpreting outcomes. @EndoSocJournals doi.org/10.1210/clinem/dgag3… #LPoM #lipodystrophy

How does lipodystrophy affect female reproductive health across the lifespan? This review connects leptin, insulin and gonadal pathways with fertility, pregnancy and management. @SpringerNature pubmed.ncbi.nlm.nih.gov/4278… #LPoM #lipodystrophy