The list of chants so far tonight. - You can't read - You eat crayons - Traitor - Matthew's better - We don't need you - Little brother - Fuck you - Brady sucks - Timmy's better -Brady’s balding - You’re a sellout - Matthew’s bridesmaid.

This isn't true. People watch full 2 hour podcast episodes on YouTube. You have to make things worth watching

Simple: ship a working version of the @theranos vision powered by SI Could be 10% of the original vision, with the promise to keep iterating For bonus points open source all the technology and patents And given the pace of super intelligence, someone will and then folks will start saying “seeeeeeeee! @ElizabethHolmes was just too early!!!” I will leave it to @nathanfielder and @JohnCarreyrou to adjudicate that moment! 😂😂😂 [ go see the film ]

Bryan, you’re right that for someone measuring hundreds of biomarkers a month, the genome adds less on the cardiometabolic side. But you’re an outlier. Most people don’t want to test themselves continuously, and most can’t. Even for you, your genome answers questions your biomarkers can’t. Blood work shows where you are now, not what’s coming. If you carried a BRCA2 variant, your prostate cancer risk would be meaningfully higher, often with earlier onset and faster progression. No panel flags that risk, but it changes when you start screening and how often. And most people with harmful variants in genes like BRCA1 and BRCA2 are not aware that they have them. There are also new and impactful discoveries still being made from the genome. We recently published a Science paper with Dana Farber on our discovery of an EGFR variant that increases lung cancer risk by 25x - far more than smoking history does (~3.8x). Lung screening guidelines are based on smoking history, so carriers go unnoticed unless someone reads their genome. The negatives matter just as much. Knowing you don’t carry a high-risk variant is information too. It enables you to know you don’t need increased screening beyond what guidelines recommend. Your APOE result counts even though it didn’t change your protocol, because it ruled something out. The genome also answers questions that go beyond your own health. For anyone planning to have kids, carrier screening shows whether both parents carry a recessive variant for a heritable condition like cystic fibrosis or spinal muscular atrophy. It’s an answer you want before a pregnancy, not after, and learning you’re not a carrier is just as valuable. This isn’t niche. On Friday at the American Society of Human Genetics (ASHG), Dr. Noura Abul-Husn presents data on ~6M people who got 23andMe health reports. More than 1 in 10 (660K+) had a medically actionable result linked to a health risk with established screening or prevention guidelines. These results change how people understand their personal health risks and empower them (and their doctors) to take action to stay healthy. Your genome isn’t a daily dashboard. It tells you which dashboard to build, and where to focus your attention.

The only opinion that I care about re: Elizabeth Holmes and "You can see everything" 👇

If you don't think that there is a bubble in AI x Bio valuations, just consider that the purported valuation of Isomorphic Labs is more than that of Revolution Medicines. Investors are acting as if preclinical Isomorphic already has an approved KRAS scale blockbuster.

No question that @IsomorphicLabs and other AI drug discovery initiatives can radically accelerate the process, which today is ridiculously protracted. But the objective or expectation of finding "cures" for all diseases is unrealistic IMHO, no matter how much capital is invested. Good summary of today's news @grok

Stepbrothers Dayyan Armstrong and Ross Beane have been adventuring together since they were both 7. With Sailing Collective, they want to bring you along. on.wsj.com/3TLeSr1

BREAKING: Elon Musk says SpaceXAI will be renamed to "SpaceXSI" after President Trump changed the name of "Artificial Intelligence (AI)" to "Super Intelligence (SI)." "No more AI. SI. It’s better," Elon Musk says.

The patient view of forever chemo for #cancer

In 1992 Peter Ratcliffe received this rejection from Nature. Almost 30 years later he won the Nobel Prize for the same discovery. Don't lose faith in the things you believe in.

This is wild... There’s a farmhouse on top of a building in the West Village in NYC, and it just listed for $10.5 million. Porch. Garden beds. A vegetable patch. City skyline instead of a backyard. The penthouse at 719 Greenwich Street.

ADDITIONAL NEWS: Anthropic says it is "drawing the line at Phase 1" for its own pipeline of rare/neglected disease programs. Kauderer-Abrams tells me he draws that line as before Phase 1 studies begin, in an effort to not compete w/ pharma customers: endpoints.news/qa-anthropics…

Zero interface in a voice interface for a task where the goal is to sift through several multifactorial options and make an educated selection. Voice is the least effective medium for that kind of task. Hard pass.

AMERICA