Biology is incredibly powerful, and more incredibly frustrating. I built/build things. Doing that again, with a new flourish.

San Francisco
Joined February 2008
Dan Widmaier 🧬/acc retweeted
nyc feels safer than sf because there are always people around you. in sf, sometimes it’s 10pm and the entire street is just you and one guy with a crowbar.
It’s hard to quantify, but I feel safer in NYC vs SF.
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Dan Widmaier 🧬/acc retweeted
In 2007, rangers weren’t sure Backpack would survive a major leg injury. 19 years later, he’s 2026 Fat Bear Week champ. Never let anyone tell you your dreams are too big.
We have a CHONKION! The #FatBearWeek crown goes to: 🐻 Bear 89 Backpack 👑 Heavy is the bear that wears the crown. Like really heavy.
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Dan Widmaier 🧬/acc retweeted
Post-economic Cursor employees watching Cognition and Factory
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Dan Widmaier 🧬/acc retweeted
VCs "adding value"
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Dan Widmaier 🧬/acc retweeted
Me watching the Cognition and Factory AI CEOs fight each other in public on Twitter (I don’t know what either company does)
We are terminating Chris Degnan for unethical conduct involving Cognition. The last few months have seen incredible progress in AI capabilities. San Francisco has flourished as new companies that solve new, more ambitious problems are finding great success. Generally, it is a wonderful time to be building. We at @FactoryAI have seen overwhelming interest in our model-agnostic coding agents and our software factory product. Our team has 10x’d in size, while our revenue has 100x’d year over year. This momentum has been unprecedented. A much larger competitor, Cognition (makers of Devin) has fallen behind us on the capabilities that matter most to customers: cost, quality, and security. Instead of competing in the market, Cognition engineers feigned interviews with us to pry information about our product. Not finding what they were looking for, Cognition has decided to throw their weight and money at people with direct knowledge of our most confidential plans. It feels as though ethics is being thrown out of the window in the AI era. People are willing to do anything, including exploiting privileged information and violating ethical boundaries. I think this is unique to our time, and I don’t think it’s right. Integrity still matters. Yesterday, I made the decision to immediately terminate Christopher Degnan’s roles as a Board Observer and Advisor to Factory, after over a year of service. Prior to this decision, Chris told me he had a casual conversation with an executive at Cognition AI. When I questioned his intentions, he reassured me that ethics aside, he had “made too much money” and was “too lazy to go work for Cognition,” which I trusted and believed. On Monday, Chris spent time advising the Factory team on a handful of confidential board-level matters. That evening, he called me to say that the conversation that was initially described as casual and one-off was actually formal and recurring. For weeks, while he sat in our board meetings and advised our leadership team, he was also confiding with executives of our largest competitor. Chris was subject to confidentiality obligations in connection with his work with Factory. We do not know the extent of the information he shared, but it puts his timely questions about our product roadmap and what the parity gap involves into a new light. It is sad to sever a relationship with someone who has been a trusted advisor - and even a close friend - for over a year. But Chris’s conduct is unacceptable to me. Trust in Board Membership is one of the sacred bonds in the Silicon Valley, one that helps the startup ecosystem thrive. With it comes an enormous responsibility. That trust was violated. Competition is good. I respect and in many cases admire our competitors. San Francisco is a beautiful, singular place where the bold and ambitious go to defy the norms and precedents of the past. But certain principles that must remain. Violating ethics to seek advantage turns what should be positive-sum into zero-sum. We all love technology. And we all love to compete. But we must hold ourselves to a higher standard. The future of software engineering comes with abundance that will impact every person on Earth. Building that future comes with immense responsibility. We must build and compete with integrity.
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Dan Widmaier 🧬/acc retweeted
this is the kind of weird stuff we should do the next time we have to incinerate a trillion dollars to stimulate the economy
A potential competitor to the Panama Canal
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Dan Widmaier 🧬/acc retweeted
I know deepmind is getting into working on watermarking bio designs, but I’ve been tagging my work for years.. (I’m just kidding for all the covid origin crazies)
Replying to @srikosuri @jbkinney
As a parting note, one of the funny things that happened last year: In 2009, I designed a large suite of orthogonal primers for synbio purposes that have made their way to a lot of public and private synbio workflows. One of the most used ones was a direct match to cov2.
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Dan Widmaier 🧬/acc retweeted
Best way to sandbox an AI is to put it on a Delta flight – it will have no chance of accessing the Internet!
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Dan Widmaier 🧬/acc retweeted
Land of the free. Home of the hefty. One nation, under chonk. Fat Bear Week finals voting begins TODAY. Who will take home the heavyweight title?
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Dan Widmaier 🧬/acc retweeted
The beauty of AI is it gets rid of all the economic leaching behavior. Anyone doing fake low value work is OUT! Delivery drivers, software engineers, banks with uncompetitive savings accounts, airlines engaging in price manipulation, gym memberships that are impossible to cancel. It allllll goes away! In the algorithmic economy agents battle so we get MAX efficiency!
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LFG! 🚀
AI is a big W for 40-somethings. Old enough to have learned how to do things the right way, young enough to learn some new tricks.
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Dan Widmaier 🧬/acc retweeted
Why does Congresswoman Nancy Mace look like she's about to give me a Soviet mission in Red Alert 2?
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Amazing, future for molecular correctors starts now 👏
First RP patient dosed in our Phase 1B/2 w/ OCT-980 Rho corrector for retinitis pigmentosa. Really thankful to the clinicians, staff, CRO partners & Octonauts for helping get this drug to patients w/ no other approved treatments. Exciting times! octant.bio/news/octant-annou…
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Dan Widmaier 🧬/acc retweeted
“Don't think for a second that because you are an alarmist that you are doing a social good.” This sentence is just devastating for so many intellectuals who need everybody to presume that they’re “the good people” Thank goodness we have Jensen!
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LFG! 👏💯🚀
Should we use @ginkgo’s autonomous lab to test if Claude’s gene editor actually works ? Lmk what you think
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Dan Widmaier 🧬/acc retweeted
Honky Chonk Beardonkadonk⁣⁣
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Dan Widmaier 🧬/acc retweeted
ok this is good well memed
giving muse access to all my code
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Dan Widmaier 🧬/acc retweeted
Replying to @bankof_amERICA
i know it sucks i had to stop working on shoes when i started data labeling
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Dan Widmaier 🧬/acc retweeted
I'm already envious of the first Army guy who gets to call in an orbital drop of an exosuit in the middle of a battle
BREAKING: The Pentagon is developing a way to launch military cargo into orbit, divide it among multiple reentry capsules, and deliver supplies near several battlefields from a single rocket. The Air Force and Space Force are moving away from the original Rocket Cargo concept, which centered on flying as much as 30 tons aboard one enormous reusable rocket. The new priority is a network of smaller, lower-cost capsules that can reenter independently and reach remote locations on land or at sea. The services jointly allocated $51.8 million to the Payload Delivery System effort in FY2026 and requested another $48.8 million for FY2027, according to Breaking Defense. AFRL has engaged SpaceX, Blue Origin, $RKLB, Sierra Space, Varda, Inversion Space, and Outpost Space as it seeks multiple capsule and launch providers. If successful, the Pentagon could pre-position critical supplies in orbit or launch them on demand, then send individual capsules toward forces operating across several distant or contested locations globally. The technology remains under development.
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Dan Widmaier 🧬/acc retweeted
dress for the job you want
the shirt, the shoes. peak male performance
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