
Cancer treatment & prevention | Founder @TuckerMedical | Genomics | Healthspan | Digital Health | Speaker | Innovator |
Singapore
Joined September 2008
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Steven Tucker, MD, FACP, FAMS retweeted
Every Expert Intelligence notebook we feature includes a note from the author and extra sources curated by them. Here's @AnnieDuke explaining how exploring her fascinating book Thinking In Bets in @Gemini_Notebook can help you make smarter decisions. notebook.google.com/notebook…
Steven Tucker, MD, FACP, FAMS retweeted
🌟 New research into 16 #epigenetic #AgingClocks across 51 studies, revealing insights on their responsiveness to various pharmacological and lifestyle changes. Could these aging clocks be the key to reliable #aging biomarkers?
dlvr.it/TV6ZlT
Steven Tucker, MD, FACP, FAMS retweeted
📚 What did you miss in #Radiology this week?
🤖 AI for breast imaging
📝 LLMs for imaging histories
🩺 CT for liver fibrosis
🦵 Vascular links to OA
🧡 HCC treatment after immunotherapy
⬇️⬇️ Catch up on the latest research ⬇️⬇️
pubs.rsna.org/toc/radiology/…
Steven Tucker, MD, FACP, FAMS retweeted
Discovery of a new (bad) impact of tau protein: crippling mitochondria in the brain
cell.com/neuron/fulltext/S08…
@NeuroCellPress
science.org/content/article/… @ScienceMagazine
Plaud release notes:
Filler words, gone. Auto Polish now cleans every transcript the moment it's generated, without touching the meaning. The original stays one tap away, and it costs zero transcription minutes.
Also new: Memory in Ask Plaud, shared Team files.
Find full notes: plaud.ai/pages/plaud-release…
Best tool yet 🧞♂️🙏🏽🏎️
Plaud's MCP just crossed a milestone worth sharing.
Within 2 months since launch, we've passed 40,000 connections to Plaud's MCP and CLI integrations — and the traffic tells the real story.
Backend API calls to our MCP endpoint have grown roughly 30x in the past eight weeks, from ~33K calls/day to 1M+ calls/day today. 🍻
Q: How often are you seeing an abnormal eGFR in creatine users?
Common enough in my practice that I had Claude build a short deck/tool on creatinine vs cystatin C.
Feedback, criticism, advice welcome. @kidney_boy - suggested edits?
tuckermedical-egfr-2026.netl…
Those were the days…real time tweets w the 140 limit #blisterwalk
Will always remember @teamoncology @DrAnasYounes & @drsteventucker were 3 of the earliest oncologists I followed back in 2008/09 - fun times & debates w/ pioneers who got SocMed
I've manually set up Hermes Agents on Hetzner for a over a dozen people on my team and / or friends / family. Excited for this launch!
Steven Tucker, MD, FACP, FAMS retweeted
Well, today seemed like as good a moment as any—while I was unpacking from vacation—to have Claude analyze my genome. This is not a trivial problem given my variant call file is over a decade old. But that also provides some nice challenges wrt file formats and ref calls.
Steven Tucker, MD, FACP, FAMS retweeted
"GPT-5.5 Pro Outperforms 99.9% of Doctors and Predicts AI Superiority in Medicine by Next Year"
An optimistic AI viewpoint since there are no studies in real world medicine; all we have now are simulations, case vignettes, patient actors, etc. Beyond that, performance metrics need work as we've recently open-source published.
Here's what the editors @NatureMedicine wrote: This study cuts through the optimism surrounding medical AI by showing how easily benchmark success can be
mistaken for real readiness. In medical AI, impressive scores are clearly not the same as trustworthy capability.” [link below]
Our results were independently confirmed by @yishan in current frontier models, such as GPT-5.5 Pro, text below
nature.com/articles/s41591-0…
xitter.cf/yishan/status/20707427…"
A big problem with research studies on AI models is that given how long the peer review process is, the results are always out-of-date by the time the paper is published.
This time, we have something better!
The typical reaction to research results like this roughly goes "You're just testing on old models. Today's models are way better and surely can do it now!"
But the best solution is for these papers to also open-source all of their testing framework so that upon publication, others can reproduce their results, as well as run it on the newest models of the day - and into the future. After all, "this is the worst they'll ever be" so what really matters is determining when they DO pass the threshold.
As it turns out, the authors of this paper DID open-source their evaluation framework!
Here:
github.com/aiden-ygu/health-…
So I figured... let's re-run the tests on the latest models!
Summary of our results are here:
github.com/ywong137/health-a…
One drawback is that, unfortunately, the authors didn't (or weren't legally able to) open-source ALL the testing data, since apparently some of it is copyrighted by JAMA/NEJM etc. That's a separate problem with the medical research publishing industry for another time.
However, we were able to reproduce the test on the public datasets they did include!
First, we re-ran the same tests (as closely as we could) on the old models the paper claimed to use, in order to establish a baseline and determine how much "drift" there would be. (Answer: not too much)
Then we ran those tests on the newest frontier models we could find.
The results are: the most capable models today (GPT-5.5 Pro) did outperform the best models from before (79/100 vs 69/100), but did not improve enough to be considered sufficient for reliable medical use.
In fact, the paper's criterion for "fit for reliable medical use" is more stringent, requiring the models to be robust under perturbation and bad data, knowing when to say there's not enough information, give clinically valid reasoning rather than hallucinations, etc. Those sound pretty reasonable to me.
I wasn't able to reproduce that kind of qualitative evaluation, but even on the basic pass/fail test using public datasets of interpreting radiology images, the newest models are better, but not yet quite good enough.
Nevertheless, I would like to praise the paper's authors for at least open-sourcing what they could, enabling me to (fairly quickly) attempt to reproduce their results. This is definitely a step in the right direction!
While my reproduction wasn't able to be comprehensive, it certainly gave me useful directional info and - perhaps more importantly - allowed me (a random dude on the internet) to directly reproduce the results in their paper and validate them.
I would like to encourage ALL authors of research papers on AI models to do similar open-sourcing of their experimental frameworks!
Steven Tucker, MD, FACP, FAMS retweeted
We recently obtained the highest-resolution 3D images of the human brain ever taken from outside the skull. This is the first look.
Introducing Aleph, a research lab building brain interfaces for the telepathic future. (1/n)
Steven Tucker, MD, FACP, FAMS retweeted
Dr Herbert Loong presenting on clinical management of early-onset cancer at #ASCOBT26, with important insights and implications for the Asia-Pacific region.
@herbloong @ASCO
Steven Tucker, MD, FACP, FAMS retweeted
A couple of gems from Howard Wolinsky- @journotwit - veteran health care journalist-turned-prostate cancer patient advocate. garyschwitzer.substack.com/p…
What pulls someone into AI? For Dr. Karan Singal (@thekaransinghal), it wasn’t code first — it was curiosity.
Hear more from Dr. Singal in the latest episode of the @NEJM_AI Grand Rounds podcast: nejm.ai/ep43
#ArtificialIntelligence #AIinMedicine
Steven Tucker, MD, FACP, FAMS retweeted
Amazon started offering a health AI assistant to @OneMedical patients in January. By March, it opened it to all 200 million U.S. Prime members.
It pulls your medical records automatically, answers questions about your symptoms and lab results, books appointments, and refills prescriptions. When you actually need a doctor, it connects you to one and sends the prescription to Amazon's pharmacy.
It's the most complete health AI tool available right now — built into an app most American households already use to shop.
buff.ly/EatrnWg @Amazon #InterpretationMigration #DrYou































