@drpnash

Rheumo, Golfer(pathetic), Caravaggisti, Prof School of Medicine Griffith University, A/Prof Univ. of Qld, Director Rheumatology Research Unit Sunshine Coast,

 Sunshine Coast
Joined December 2011
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93Media
Cardiovascular Outcomes with Romosozumab Versus Alendronate in Osteoporosis: A Real-World Propensity-Matched Cohort Study acrabstracts.org/abstract/ca… further reassurance - patient concerns ++ #romosozumab #RheumNow

Cardiovascular Outcomes with Romosozumab Versus Alendronate in Osteoporosis: A Real-World Propens...

Background/Purpose: Romosozumab, a sclerostin inhibitor used in severe osteoporosis, carries a U.S. Food and Drug Administration boxed warning for cardiovascular events based on the ARCH trial in...

acrabstracts.org
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Transition from psoriasis to psoriatic arthritis: Pain perspective from the Turkish National Health Database (e-Nabız) acrabstracts.org/abstract/tr… don't ignore persistent pain in PsO #PsA #RheumNow

Transition from psoriasis to psoriatic arthritis: Pain perspective from the Turkish National Health...

Background/Purpose: We aimed to evaluate the frequency, timing, and specialty distribution of outpatient visits for musculoskeletal pain in the years preceding a new diagnosis of PsA. Methods: Data...

acrabstracts.org
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Cardiovascular safety of upadacitinib, tofacitinib, and tumor necrosis factor alpha inhibitors in rheumatoid and psoriatic arthritis acrabstracts.org/abstract/ca… not all Jaks are the same #JAKi # RheumNow

Cardiovascular safety of upadacitinib, tofacitinib, and tumor necrosis factor alpha inhibitors in...

Background/Purpose: The postmarketing ORAL Surveillance trial identified an increased risk of major adverse cardiovascular events (MACE) among patients who initiated therapy with the janus kinase...

acrabstracts.org
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Efficacy and Safety of Baricitinib in Active Sjögren disease: A Multicenter, Randomized, Controlled Trial acrabstracts.org/abstract/ef… better than HCQ - great unmet need #baricitinib #RheumNow

Efficacy and Safety of Baricitinib in Active Sjögren disease: A Multicenter, Randomized, Controlled...

Background/Purpose: Sjögren disease (SjD) lacks approved treatments targeting systemic involvement. While preliminary studies have highlighted the potential of the Janus kinase (JAK) inhibitor...

acrabstracts.org
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Add-on Tirzepatide therapy leads to Improvements in Pain & Clinical Outcomes in Patients with Obesity & Psoriatic Disease & Patients with Obesity & Non-Inflammatory Arthralgia: Interim Results Prospective Cohort Study acrabstracts.org/abstract/ad… hard to argue with #GLP-1 #RheumNow

Add-on Tirzepatide therapy leads to Improvements in Pain and Clinical Outcomes in Patients with...

Background/Purpose: Obesity is a common comorbidity in psoriatic disease and is associated with increased disease activity, pain, and poorer outcomes. Glucagon-like peptide-1 receptor agonists...

acrabstracts.org
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Safety Outcomes Among Patients With Polymyalgia Rheumatica Treated With Interleukin 6 Inhibitors acrabstracts.org/abstract/sa… time to avoid oral steroids in PMR - start with an IMI depot steroid for immediate relief and start steroid sparer at diagnosis?

Safety Outcomes Among Patients With Polymyalgia Rheumatica Treated With Interleukin 6 Inhibitors -...

Background/Purpose: Polymyalgia rheumatica (PMR) is a chronic inflammatory rheumatic disease for which glucocorticoids (GCs) remain first-line treatment. However, relapse is common during GC taperi...

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#PMR @RheumNow
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Kreis L, Petzinna S, Kern S,MTX for Remission Maintenance Following Tocilizumab & GCs Induction in GCA Randomized METEORITICS Trial Arthritis Rheumatol. 2026; 78 (suppl 9). acrabstracts.org/abstract/mt…. Accessed October 3, 2026. is there really a role for MTX in GCA? #GCA #RheumNow
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Bagrova A GLP-1 Receptor Agonist Use Reduced Major Adverse Cardiovascular Events GCA : Retrospective Cohort Study Using TriNetX Database. Arthritis Rheumatol.2026; 78 (suppl 9). acrabstracts.org/abstract/gl…. Accessed October 3, 2026- Should be in the water supply #GLP-1 #RheumNow

GLP-1 Receptor Agonist Use Is Associated with Reduced Major Adverse Cardiovascular Events in...

Background/Purpose: GCA carries a 1.5- to 2-fold increased risk of major adverse cardiovascular events (MACE) compared to the general population. Randomized and observational studies have demonstra...

acrabstracts.org
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Zhou L, Hu J, Hu J, Yue Y,et al Induction of B Cell Aplasia with cGP130 Armored-CAR T Cells Without Lymphodepletion [abstract]. Arthritis Rheumatol. 2026; 78 (suppl 9). acrabstracts.org/abstract/in… - no lymphodepletion might change the ballgame #CAR-T #RheumNow

Induction of B Cell Aplasia with cGP130 Armored-CAR T Cells Without Lymphodepletion - ACR Meeting...

Background/Purpose: The clinical application of CAR-T therapy remains limited by its dependence on lymphodepleting chemotherapy. Although cytokine support can enhance CAR T cell persistence and...

acrabstracts.org
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OP002 (2026) ANIFROLUMAB TREATMENT IN PATIENTS WITH SJÖGREN’S DISEASE: EFFICACY AND SAFETY ASSESSMENT IN A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE IIA PROOF-OF-MECHANISM TRIAL (ANISE-II) anifrolumab works in SjD - high interferon signature works the best? #EULAR2026
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POS0773 (2025) LOW UVEITIS RATES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS OR PSORIATIC ARTHRITIS TREATED WITH BIMEKIZUMAB: LONG-TERM RESULTS FROM PHASE 2B/3 TRIALS - 5000 pt yrs AxSpA & PsA - low uveitis rates - bime or selection? #bimekizumab #uveitis #AxSpA #PsA
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POS0109 (2025) COMPARATIVE PERSISTENCE AND EFFECTIVENESS OF IXEKIZUMAB VERSUS OTHER b/tsDMARD CLASSES IN REAL-WORLD PsA TREATMENT: 12-MONTH RESULTS FROM THE PRO-SPIRIT STUDY - a practical comparison #ixekizumab #TNF #IL23i
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OP0096 (2025) Sonelokimab, IL-17A- & IL-17F- Nanobody, outcomes PsA: Ph 2 ARGO trial SLK 60mg n=41 SLK 120mg n=43 ADA ref n=42 MDA(n/%) 25 (61.0). 22 (51.2). 19 (45.2) nanobody effective- question is same or better? #IL17 #nanobody #sonelokimab
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OP0091 (2025) MARKERS OF IL-17 SIGNALLING IN THE BLOOD OF PATIENTS WITH PSORIATIC ARTHRITIS WITH INADEQUATE RESPONSE TO TUMOUR NECROSIS FACTOR INHIBITORS interesting - 17F raised in TNF non-responders PsA - #IL17F #PsA #TNF-IR
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12 mths AbA delays RA up to 3 yrs esp if high titre ACPA
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Hence the Emery editorial in Rheumatology journal - biosimilar Toci from day 1 #RA #Tocilizumab #MTX
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stratify for gender baseline clinical trials jrheum.org/content/early/202…

Prevalence and predictors of achieving sustained remission in psoriatic arthritis. A Swedish...

Objective To estimate the prevalence and predictors of sustained remission (SR) in psoriatic arthritis (PsA) patients receiving biologic or targeted synthetic disease-modifying antirheumatic drugs...

jrheum.org
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no excuses jrheum.org/content/early/202…

The Impact of Early Attainment of Minimal Disease Activity on Radiographic Outcomes: A Real-World...

Objective To evaluate the effect of achieving Minimal Disease Activity (MDA) within the first year on radiologic damage at follow-up 3 years in patients with newly diagnosed Psoriatic Arthritis...

jrheum.org
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Zepbound and Wegovy Go Head to Head for Obesity: And the Winner Is ... medpagetoday.com/endocrinolo… need the best for IMIDs

Zepbound and Wegovy Go Head to Head for Obesity: And the Winner Is ...

Benefits extended beyond weight loss as well

medpagetoday.com
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