Ocular Rheumatologist | @WUSTL_Rheum @WUDeptMedicine | T cell biology and scRNAseq/TCRseq | full of dry and nerdy humor
St. Louis, MO
Joined May 2021
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We are thrilled to have been part of a multi-institutional, multidisciplinary group to identify disease-associated T cells in #AnkylosingSpondylitis & Anterior #Uveitis that recognize antigens presented by HLA-B27, published in @Nature. (1/9)
You can now view our abstract using this link and the summary images below: biorxiv.org/content/10.6...
@obigriffith @malachigriffith @XinboYang777
#Rheumatology #axSpA #ChooseRheum
(1/4)
(4/4) Thank you, @NIH, @CureArthritis & @spondylitis, for your continued support!
#Rheumatology #axSpA
Thank you, @KilianMD, for inviting me to speak at St. Louis University's Rheum Grand Rounds this morning! It's always great to see our neighbors to the East and talk shop!
@WashUMedRheum #Rheumatology
Excited to share new findings from my #Spondylitis research! Join me & Dr. Barhram Razani in the @CureArthritis Research Spotlight Series on 9/18. We’ll discuss the latest treatment breakthroughs & research. Register today: bit.ly/RSS24PsA #PsA #ArthritisResearch
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
An enteric start to HLA-B27-associated autoimmune disease? insight.jci.org/articles/vie…
Work from @drmapaley, @XinboYang777 et al. suggests early antigen exposure in gut leads to pathogenic CD8+ T cell development in axial spondyloarthritis & acute anterior uveitis.
@WUSTLmed
(1/7)Excited to see our latest manuscript in press at @JCI_insight (doi.org/10.1172/jci.insight.…)! This was a great extension of our continuing multi-institutional, multidisciplinary group to better understand pathogenic CD8 T cells in #axialspondyloarthritis & anterior #uveitis.
(6/7) We think that more in depth TCR profiling will be needed to stratify patients prior to selecting therapies like BCD180.
(7/7) As always, we must thank key funders who supported this campaign to better understand and treat #spondylitis and #uveitis: @RheumResearch, @CureArthritis, @NIH_NIAMS, #HHMI.
@wustl_rheum @WUDeptMedicine
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
Pharmacy benefit managers act as middlemen overseeing prescriptions for millions of Americans to reduce drug costs. A New York Times investigation found they charge steep prices for patients, employers and the government. Our reporter explains how. nyti.ms/3RESDih
Really enjoyed the invitation to be on Spondycast and talk about where we are for #HLA-B27 research for #axSpA and #Uveitis and where we might be going. Really excited about the possibility of new #Diagnostics and #Therapeutics.
@spondylitis
🎙Dive into the latest episode of Spondycast, where host Jill Miller & award-winning ocular rheumatologist @drmapaley enlighten us on his groundbreaking research! Check it out here: spondylitis.org/podcasts #inflammation #uveitis #gut #microbiome
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
🎙Dive into the latest episode of Spondycast, where host Jill Miller & award-winning ocular rheumatologist @drmapaley enlighten us on his groundbreaking research! Check it out here: spondylitis.org/podcasts #inflammation #uveitis #gut #microbiome
Michael Paley, M.D., Ph.D. (moving to @Bluesky) retweeted
"total number of TCRs in a human, supports Mason’s notion that we should #abandon the ‘one-clonotype–one-specificity’ paradigm suggested by clonal selection theory in favour of a ‘one-clonotype–millions-of‑specificities’reality" nature.com/articles/nri3279
Check out our new lab website: paleylab.com
#Research