@drdavidc

Respiratory @NHSTayside | Hon Sen Lect @dundeeuni | Complex Lung Infections | Co-Chair Scottish TB Network | Own opinions

 NE Fife | Tayside
discovery.dundee.ac.uk/en/persons/david-connell
Joined December 2010
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🧫🟢 ¿Por qué un hongo puede ser "susceptible" en el laboratorio 🔬, pero el paciente no mejora? 🏥🤔 📖 The Lancet Infectious Diseases explica por qué la concentración mínima inhibitoria (CMI) no predice por sí sola la respuesta clínica. #Micología #Antifúngicos 🍄🧬 La respuesta depende de múltiples factores: 🔬 Especie fúngica 💊 Exposición al antifúngico 📍 Foco de infección 🦠 Biopelículas y persistencia 🛡️ Inmunidad del paciente 📊 Los autores proponen un algoritmo para investigar las discrepancias entre laboratorio y evolución clínica. 🩺🔍 ¿Qué hacer? ✅ Integrar datos clínicos y farmacocinéticos. 💊 Monitorizar el antifúngico cuando esté indicado. 🎯 Controlar el foco infeccioso. 💡 👇🏻 doi.org/10.1016/S1473-3099(2… #Microbiología #InfeccionesFúngicas @SEMicrobiologia
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Hayoung Choi@hayoungccOct 8
📢Happy to share an editorial, just published in @ThoraxBMJ, on a post hoc analysis of the CLEAR trial (PMID: 42557060)! To test or not to test: reassessing the need for drug response assessment before inhaled hypertonic saline thorax.bmj.com/content/early…

To test or not to test: reassessing the need for drug response assessment before inhaled hypertonic...

Medicine is replete with preadministration safety rituals that seemed self-evident until they were formally studied. Routine skin testing before cephalosporin administration, for example, was...

thorax.bmj.com
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IDSA
@IDSAInfoJul 2
New #IDSAGuidelines! IDSA has released updated evidence-based recommendations on the prevention of invasive aspergillosis in adult solid organ transplant recipients: bit.ly/4whe7Dx
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🆕💥ENCORE RCT A Phase 3b, Double-blind, RCT Amikacin Liposome Inhalation Suspension ( ALIS) In Newly Diagnosed Mycobacterium avium Complex Lung Disease #IDXposts academic.oup.com/ajrccm/adva…
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ERJ Open Research: Treatment of patients with bronchiectasis with hypertonic saline or carbocisteine does not significantly reduce sputum viscoelastic properties and biomarker levels or alter bacterial community composition bit.ly/4r2X2KA
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ATS Blue Journal@ATSBlueEditorSep 20
Airway mucus plugs in asthma and #COPD: pathobiology, imaging, and implications for clinical trials doi.org/10.1093/ajrccm/aamag… @atscommunity

Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and...

Abstract. Mucus plugs have been previously recognized as an important pathological feature in asthma and chronic obstructive pulmonary disease (COPD), but

academic.oup.com
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ERJ Open Research: CPA/ABPA overlap represents a distinct clinical phenotype in individuals with CPA associated with underlying airway disease, antifungal resistance and Th2-driven inflammation, with rising biomarkers linked to disease progression bit.ly/4eR5Xwv
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Breathe: Structural sequelae after TB underpin infectious PTLD: bacterial, fungal and non-TB mycobacterial. Complications are frequent yet under-diagnosed, worsening mortality and quality of life. bit.ly/4viER5M
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Dr. Thomas Ichim
@exosomeSep 20
Wow! multiple sclerosis is caused by viral reactivation in monocytes and B cells months before clinical onset. nature.com/articles/s41591-0…

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse

Nature Medicine - Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to...

nature.com
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ATS Blue Journal@ATSBlueEditorSep 18
Diagnostic criteria for invasive pulmonary aspergillosis in #COPD patients doi.org/10.1093/ajrccm/aamag… @atscommunity

Diagnostic criteria for invasive pulmonary aspergillosis in chronic obstructive pulmonary disease...

Abstract. More than 400 million people have chronic obstructive pulmonary disease (COPD), with exacerbations representing a major health burden. Although t

academic.oup.com
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Bronchiectasis is driven by dynamic host–microbiome interactions, not single pathogens. Integrating microbial and immune multi-omics can define actionable endotypes, enabling precision therapy and accelerating translation from discovery to clinical care. bit.ly/4xfavDv
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The Courier@thecourierukSep 16
Former health board chair claims ‘someone’ at NHS Tayside tried to shut down Eljamel scandal dlvr.it/TVW8m8

Former health board chair claims 'someone' at NHS Tayside tried to shut down Eljamel scandal

Professor John Connell was scathing in his assessment of former colleagues.

thecourier.co.uk
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Naftali Kaminski@KaminskiMedSep 14
Wow! Two Phase 3 RCTs demonstrate that tozorakimab, an IL33 monoclonal antibody reduces moderate-to-severe COPD exacerbations by 29% to 34%. Kudos @FrankS1956 & all Oberon, Titania investigators and #ShanaTova to the #CureCOPD community!!! nejm.org/doi/full/10.1056/NE…

Tozorakimab to Prevent COPD Exacerbations | NEJM

Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicate...

nejm.org
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NTM Info & Research@NTMinfoSep 13
Join Prof. James Chalmers for highlights from the ERS Congress in Barcelona! Get the latest research and clinical breakthroughs in Bronchiectasis & NTM from the world's largest respiratory meeting Learn more: bit.ly/2MenuSH #ERSCongress #NTMAwareness #Bronchiectasis
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Scottish Government
@scotgovSep 10
New guidance for landlords and tenants has been published ahead of new laws on damp and mould complaints. From 6 October 2026, landlords must look into reports of damp or mould. They must also start repairs within a set time.
Awaab's Law: Guidance for tenants and landlords in Scotland. From 6 October 2026, landlords must look into reports of damp or mould. They must also start repairs within a set time.

ALT Awaab's Law: Guidance for tenants and landlords in Scotland. From 6 October 2026, landlords must look into reports of damp or mould. They must also start repairs within a set time.

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Journal of Fungi MDPI@JoF_MDPISep 9
A new review in Journal of Fungi explores the fungi associated with moisture problems, building materials, sampling methods, and detection techniques. Read the full review: doi.org/10.3390/jof10020108 #Fungi #Mycology #BuildingScience #Mold #JournalOfFungi
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Emily Ward@draw_e87Sep 8
Fantastic overview of use of tobramycin nebulisers and eradication of pseudomonas in patients with BE from Jin-fu Xu Perhaps we can ditch the ciprofloxacin and the many risky side effects? Exciting data to see #ERSCongress
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Journal of Fungi MDPI@JoF_MDPISep 8
New Special Issue: Antifungal Resistance in Clinical Fungi 📅 Submission deadline: 28 February 2027 👨‍🔬 Guest Editor: Dr. Andres Ceballos-Garzon Explore the Special Issue and consider contributing your latest research: mdpi.com/journal/jof/special…
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Emily Ward@draw_e87Sep 6
Bronchiectasis patients have a reduced microbiome diversity, increased haemophilus and decreased commensals. The @dundeeuni BRILLIANT study shows the microbiome differences. Absolutely fab presentation from Hollian #ERScongress @ProfJDChalmers @drdavidc @HelenLiddicoat
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Journal of Fungi MDPI@JoF_MDPIAug 31
How does the immune system respond to Aspergillus infection? A review in J. Fungi explores the interplay of cytokines and chemokines in aspergillosis, highlighting how Th1, Th2, and Th17 immune responses shape disease outcomes. doi.org/10.3390/jof10040251 #JoF #Aspergillosis

Interplay of Cytokines and Chemokines in Aspergillosis

Aspergillosis is a fungal infection caused by various species of Aspergillus, most notably A. fumigatus. This fungus causes a spectrum of diseases, including allergic bronchopulmonary aspergillosis,...

mdpi.com
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