Professor of Neurology, Neurosurgery & Radiology Rush University Medical Center Editor, Journal of NeuroInterventional Surgery

Chicago, IL
Joined March 2012
Michael Chen, MD retweeted
🌀 Why do some aneurysms occlude quickly after flow diversion despite persistent high-speed flow? This JNIS study suggests that aneurysm occlusion is not driven by flow reduction alone. In fast-occluding aneurysms, progressive fibrin accumulation across the flow diverter disrupted the inflow jet, increased neck coverage, and substantially reduced intra-aneurysmal velocity. A fascinating look at the biology and hemodynamics behind successful flow diversion. 🔗 bit.ly/47SQp6m #JNIS #FlowDiversion #Aneurysm #Neurointervention
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Michael Chen, MD retweeted
Can we predict how a flow diverter will actually deploy before we deploy it? 🧠💻 In a real-world simulation-guided workflow, Ankyras closely predicted PED: 🎯 Deployed length: MAE 1.24 mm 📍 Proximal landing zone: MAE 1.34 mm 📈 Strong correlations: r=0.91 and 0.94 Virtual planning may be moving closer to real-world deployment. 🔗 bit.ly/4hXsoRS #JNIS #FlowDiversion #BrainAneurysm #Neurointervention
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Michael Chen, MD retweeted
Can superbore aspiration push first-pass reperfusion further? 🧠 The prospective multicenter MARRS trial evaluated the corrugated Millipede aspiration system in 180 patients with LVO stroke. 🎯 88.9% mTICI ≥2b within ≤3 passes without rescue ⚡ 75% FPE in M1 occlusions treated with Millipede88* 📈 82.2% final mTICI ≥2c overall 🛡️ 2.3% sICH | 0 perforations *Per-protocol M1 subgroup. 🔓 Open Access: bit.ly/3UwpjPg #JNIS #Stroke #Thrombectomy #Neurointervention #Aspiration
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Michael Chen, MD retweeted
First publications are out for JNIS Advances! A major milestone for our society @SNISinfo, our family of journals @JNIS_BMJ, and our field. I’m proud of our team and look forward to more high impact research coming soon. jnisadvances.bmj.com/content…
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Michael Chen, MD retweeted
When CSF disappears into the venous system, how do you find the fistula? 💧🧠 A comprehensive JNIS review of CSF–venous fistulas takes us from pathophysiology to localization and treatment: 🔎 Decubitus DSM & CTM 🩸 Percutaneous therapies 🧭 Transvenous embolization 🧠 Surgery & post-treatment care A practical roadmap for a rapidly evolving field. 📖 Read the full review: bit.ly/4fV6QCP #JNIS #CSFLeak #Neurointervention #SIH
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Michael Chen, MD retweeted
Why do some aneurysms remain patent after flow diversion? 🧠 In 185 aneurysms, branch involvement was the strongest predictor of incomplete occlusion. But not all branches behaved alike—accounting for collateral circulation improved prediction scores. 🔗 bit.ly/3TKoAtm #JNIS #FlowDiversion #Aneurysm #Neurointervention
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Michael Chen, MD retweeted
What causes acute periorbital swelling after EVT? This case series highlights an uncommon but important complication following EVT: the spectrum of orbital infarction syndrome (OrbIS) and secondary orbital inflammation (SOIN). Recognizing the differences in timing, clinical presentation, and visual outcomes may help guide early diagnosis, ophthalmology consultation, and multidisciplinary management. 📖 Read more at bit.ly/3RGib1E
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Michael Chen, MD retweeted
🎤 The final lecture of SNIS 2026 featured @JMoccoMD’s Medicolegal Perspective, offering valuable insights into navigating risk and responsibility in neurointerventional practice. Key takeaways included the importance of documenting clinical decision-making, engaging patients through a true consent process, and recognizing communication as a modifiable factor in reducing medicolegal risk. A powerful reminder that transparency, trust, and the physician-patient relationship remain central to excellent care. 🧠
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Michael Chen, MD retweeted
🧊 This in vitro study demonstrates that catheter insulation, flow rate, and proximal blood flow control are key determinants of intra-arterial brain cooling efficiency. An insulated co-axial catheter combined with balloon guide catheter inflation achieved the greatest predicted brain temperature reduction. Read more here: bit.ly/4wfNb78
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Michael Chen, MD retweeted
📢 Published in JNIS: An ESMINT-led European multisociety consensus provides the first indication-specific recommendations for evaluating thrombectomy devices under the European MDR. 🔬 New clinical evidence standards for stroke devices. 🔗 buff.ly/ujXSDVI
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Michael Chen, MD retweeted
bit.ly/44pX8D4 New in @JNIS_BMJ - honored to formally introduce JNIS Advances, the newest neurointerventional journal from @SNISinfo. Be a part of something big, submit your original research today!
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Michael Chen, MD retweeted
Replying to @dr_mchen
Seeing some great new studies for the first issue of JNIS Advances, from stroke to surgery and from new devices to outcome prediction. Submit your work now for rapid, expert peer review and a chance to be included in vol. 1 no. 1! jnisadvances.bmj.com/pages/a… @SNISinfo @JNIS_BMJ
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Michael Chen, MD retweeted
🎧 A new episode of the JNIS podcast has been released: Evaluating the 90-day safety and technical feasibility of a percutaneous transvenous approach represents a critical milestone for routing cerebrospinal fluid (CSF) – the clear liquid that cushions the brain and spine – directly into the venous system. In this episode, JNIS Editor, Dr. Michael Chen, talks with corresponding author Professor Adel Malek (Tufts Medical Center, Boston) to discuss his high-impact paper, "Safety of endovascular shunting for normal pressure hydrocephalus from a prospective, multicenter, single-arm study”. bit.ly/44aBNxm Listen & subscribe to the JNIS Podcast on your favorite platform: ▶️ Apple: apple.co/4gf7Fbu ▶️ Spotify: bit.ly/4vOlt11 ▶️ Web: bit.ly/4eHNWQv
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Michael Chen, MD retweeted
💡 NVS-Gel1, a novel photoactivated liquid embolic agent, enabled operator-controlled, on-demand solidification with precise embolic control in a large-animal model. These proof-of-concept findings support further evaluation for neurovascular applications. Read more here (open access): bit.ly/49O9Xuf
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Michael Chen, MD retweeted
🔍 Meningeal diverticula in patients with spontaneous intracranial hypotension may serve as an additional imaging marker to facilitate CVF diagnostic workup. Read more here (open access): bit.ly/3QpKLDN
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Michael Chen, MD retweeted
JNIS Advances is a new open access journal that will publish the latest research into neurointerventional techniques and devices. Our first issue will be released at the SNIS Annual Meeting, so be sure to get your submissions in! You can learn more here: jnisadvances.bmj.com/ @SNISinfo
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Michael Chen, MD retweeted
What defines best practice in diagnostic cerebral angiography (DCA) today? These updated guidelines provide evidence-based recommendations for contemporary DCA practice, spanning technique, safety, complication management, reporting, and patient-centered care. 🧠📖 @SNISinfo @esmintsociety @anzsnr 🔗 Read more at bit.ly/42IHF0e
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Michael Chen, MD retweeted
📚 Journal of NeuroInterventional Surgery (JNIS) provides a peer-reviewed forum for work that advances the field with rigor and relevance, supported by an international editorial community and a shared commitment to scientific quality. ➡️ Impact Factor: 4.4 ➡️ CiteScore: 8.8 ➡️ Acceptance rate: 18% ➡️ Median time to first decision: 16 days ➡️ Indexed in: PubMed, Web of Science, Scopus ➡️ Official journal of: SNIS, ESMINT, ANZSNR, CING, HKSITN, NRST, STNI 🔗 Submit your article here: bit.ly/4uKkrmt
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Michael Chen, MD retweeted
Could targeting the middle meningeal artery help reduce headache and opioid use after aneurysmal subarachnoid hemorrhage? In this JNIS pilot study, MMA infusion of lidocaine ± dexamethasone during aneurysm embolization was associated with reduced pain burden, lower opioid use, and no complications in patients with low-grade aSAH. @PeterKa80460001 @utmbhealth @UTMBNeurosurg @DrHongTao Read more: bit.ly/3OZgScN
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Michael Chen, MD retweeted
The Bee Foundation is now accepting applications for our Research Grant, supporting innovative work focused on brain aneurysm prevention, early detection, and treatment. With 30,000 ruptures each year and 40% resulting in death, the need for research has never been more urgent. 👉 If you’re a researcher ready to make an impact, we encourage you to apply. thebeefoundation.org/brain-a… The future of prevention starts with research.
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