Diabetes & Endocrinology Consultant London, worked @ UCLH & Royal Free , MSc Diabetes ,MRCP , SP interest Obesity,TV presenter speaker ,Tweet & RT personal

London, England
Joined September 2010
Pleased to share our AGA Clinical Practice Update on #MetALD: 9 best practice advice statements on diagnosis, fibrosis assessment, and management. Addressing metabolic risk and alcohol use together is central to care. @AGA_CGH authors.elsevier.com/a/1nq5Q…
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At #EASD2026, Erik Werson highlights that diabetes education must go beyond knowing your blood glucose to knowing what to do about it. AI could provide personalised insights and practical guidance - but access to the technology is key.
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Umaira Aziz retweeted
2️⃣ Tirzepatide 10 and 15mg vs 7.2mg semaglutide for obesity via indirect comparison of SURMOUNT-5 and STEP UP, as both trials involved 2.4mg semaglutide as a reference point. ▪️In the treatment regimen estimand (TRE) tirzepatide 10 and 15 mg were associated with statistically greater reductions from baseline in weight (%) vs semaglutide 7.2 mg: mean difference (95% CI) for 10 mg -3.17 (-5.01, -1.40) and 15 mg -4.51 (-6.31, -2.80) (Table 1). ▪️Tirzepatide 15 mg was associated with statistically greater odds of ≥20% weight reduction vs semaglutide 7.2 mg, while tirzepatide 10 mg was associated with no statistically significant difference. Graphs that I’ve included from STEP UP are both TRE and efficacy estimand while SURMOUNT-5 is just the TRE. (Study was funded by Lilly, but Wilding, the lead author ran STEP 1 for sema that gave sema its obesity indication.)
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It is also really hard to differentiate adult onset T1D from T2D using the common measures. Even antibodies drop off with age. #EASD2026 #dedoc⁰
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Variable islet antibody (IAb) testing increases diabetes misclassification. IAb testing reclassified 13% of people with diabetes as having type 1 diabetes, 51% of whom were diagnosed >5 years prior. #T1D Read here ➡️ doi.org/10.2337/doc26-0071 @AmDiabetesAssn @ADA_DiabetesPro
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SURPASS CVOT sub analysis for retinopathy with Tirzepatide. No worsening when compared to Dulaglutide @EASDnews #EASD2026
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Umaira Aziz retweeted
Behind all the buzz about continuous glucose monitors, #EASD2026 brings us evidence that lends credence to the idea that this technology can help people live longer. conscienhealth.org/2026/09/2…
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Umaira Aziz retweeted
We’ve entered an exclusive license agreement with Hengrui Pharma to develop a potential once-weekly pill for people living with obesity or type 2 diabetes. Learn more in our press release here: novonordisk.com/content/nnco…
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Umaira Aziz retweeted
🚨Retatrutide TRIUMPH-1 (NEJM) 80 wk weight: ⤵️25% on 12 mg vs -3.9% placebo. ⤵️28.3% headline = efficacy estimand. 👉9 vs 12 mg near identical; only 54% still on 12 mg at wk 80 ⚠️⚡️Dysaesthesia, hypotension, MACE 9 v 1 (small n) Treat to target, not max dose❓ 🔗 nejm.org/doi/full/10.1056/NE…
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🆕 EASL-EASD-EASO guidance on resmetirom and semaglutide as #MASH-targeted therapy 💉#Semaglutide: preferred in patients with obesity, T2D or high cardiovascular risk 💊#Resmetirom: prioritised in those without obesity or unable to use GLP-1RAs 🔗bit.ly/4ynVQpR
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Umaira Aziz retweeted
Exome findings in children with short stature evaluated by growth hormone stimulation testing by Idoia Martinez de Lapiscina et al EJE Volume 194, Issue 2, February 2026 👉 doi.org/10.1093/ejendo/lvag0… ESE members free via 👉 my.ese-hormones.org #endocrinology #growth
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Umaira Aziz retweeted
The media coverage of our @ImperialMed paper today was everything I could possibly hope for having spent many years raising awareness around early-onset type 2 diabetes I am so very grateful to my co-authors and to everyone who recognised the importance of the work 🙏🏼🙏🏼 We were showcased by #BBCNews, #ITN, #Womenshour on Radio 4, BBC #radio5Live and #TimesRadio to name a few plus many newspapers Here I am looking earnest on ITN news this lunch time! And of course a selfie with the lovely Nina Hossein - amazing experience!
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Umaira Aziz retweeted
Cardiovascular–kidney–metabolic syndrome links obesity, diabetes, chronic kidney disease, and cardiovascular disease into one connected framework. Understanding the stage helps you screen earlier, stratify risk better, and intervene before overt cardiovascular events develop
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People who have MASLD, their risk of developing diabetes is doubled even after correcting for obesity. #heartuk @heartukcharity #MASLD
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Umaira Aziz retweeted
Just published! Our real world evidence for Omnipod 5 which identifies the key settings for optimal outcomes: 6.1 mmol/L target I:C ratio ≤350/total daily insulin dose CF ≤83/TDD [mmol/L] ≥90% time in Automated Mode ≥3 boluses/day journals.sagepub.com/doi/10.… – at Quarndon, England
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Umaira Aziz retweeted
In patients with GN (n=903) in FIND-CKD, treatment with finerenone: - Slowed the rate of GFR decline - Reduced UACR by 42% - Lowered the risk of kidney failure or 40% decline in eGFR by 26% Results consistent regardless of GN subtype & SGLT2i use #ERA26 jamanetwork.com/journals/jam…
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Sharing our review article: “Dulaglutide in the Era of Tirzepatide and Semaglutide: Reaffirming Its Role in Contemporary Cardiometabolic Care.” In an era where semaglutide and tirzepatide have raised expectations for HbA1c and weight reduction, our article revisits an important clinical question: does dulaglutide still have a meaningful role? We highlight that dulaglutide remains a complementary, not obsolete, incretin-based therapy—supported by robust cardiovascular outcome evidence, especially from REWIND, practical tolerability, simple once-weekly use, and easier attainment of therapeutic dosing in routine care. Its relevance is particularly strong for primary cardiovascular prevention, older adults, patients intolerant to more potent incretin therapies, and cost-sensitive or resource-limited settings. This article may interest clinicians seeking a pragmatic framework for incretin selection beyond potency alone—balancing efficacy, safety, adherence, affordability, and access. Link to read: link.springer.com/article/10… Note: At the time of writing, generic semaglutide was not available in India; however, our article does not specifically analyze generic semaglutide.
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VESPER-2 studied monthly GLP1 berobenatide in those w T2D and overweight/obesity. 2.2% A1c reduction in the highest dose group 10.2% weight reduction in a population that was skewed with more male, older, and minority groups more representative to general populations. No dose dependent GI side effects. 18-23% nausea in drug vs. 11.5 placebo. 11-15% vomiting in drug vs 4% in placebo #ADASciSessions
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