@dillinlab

Dillin lab @UCBerkeley 🧫🧬🔬🐛 Investigating the molecular mechanisms of aging and cellular/organismal proteostasis @berkeleyMCB @UCBerkeleyNeuro @HHMINEWS

 Berkeley, CA
dillinlab-berkeley.org
Joined May 2017
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The Dillin Lab has moved to Bluesky. Come join us: bsky.app/profile/dillinlab.b…
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Congratulations to Holly Gildea on acceptance of her thesis work in Science Advances! A preprint of her work describing how glial cells coordinate the heat shock response can be found on BioRxiv here: biorxiv.org/content/10.1101/…

Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory...

As organisms age, they lose the ability to induce appropriate stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protect...

biorxiv.org
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10 years working with this wonderful person! Congrats Larry on your 10 year anniversary in the Dillin lab!
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ncbi.nlm.nih.gov/pmc/article… If you love genetics and metabolic pathways, this is the paper for you!
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Dillin lab Gelato Happy Hour to welcome rotation student Mars Torres from the Helen Wills Neuroscience Graduate Program!
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The Dillin lab welcomes graduate student Weijing Tang from the MCB program!
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Congratulations to Koning Shen, PhD for her outstanding post-doc award from the MCB department!!!
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Check out our newest pub in JCB! rupress.org/jcb/article/221/… Decreased mitochondrial import from stress activates mtUPR, but then how do all those mitochondrial-saving expressed genes get back in? (1/2)

The UPRmt preserves mitochondrial import to extend lifespan

UPRmt increases mitochondrial quality control proteins and induces longevity. But how do the rescuing proteins enter mitochondria, as UPRmt is initiated wi

rupress.org
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We find that the mtUPR also increases import that may help all these great proteins get in and save the organelle. This increased mitochondrial import is also essential for lifespan extension. If you are curious about mitochondria and longevity - this paper is for you!
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Congratulations to @holly_gildea for closing out the Thesis Research Presentations with an amazing talk! Dr Gildea, we are so proud! #micdrop #PhDone
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Sent in our order and excited to get strains from @SunyBiotech. Makes genome editing a breeze, like this cool endogenously-tagged mCherry strain!!
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Hats off to @philfrankino for a SKN-tillating Thesis Research Presentation! He's officially Dr Phil now - congratulations! #PhDone
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Congratulations to @mellymetcalf for a successful Thesis Research Presentation! The Dr is in! #WomenInSTEM #PhDone
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Congrats to MCB's Andy Dillin @dillinlab on the 2022 Lurie Prize in Biomedical Sciences! 👏
Foundation for the National Institutes of Health
@FNIH_Org14 Apr 2022
The FNIH announces that @Stanford’s Dr. Anne Brunet and @UCBerkeley’s Dr. Andrew Dillin will receive the 2022 Lurie Prize in Biomedical Sciences for their independent but complementary research in biological mechanisms of aging. Learn more: bit.ly/3uuYjQz
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Huge congratulations to @tayladhunter on a well deserved Goldwater Scholarship! Tayla did a fantastic job in our lab this past summer working with @holly_gildea. Any MD/PhD program would be lucky to have her!
Holly Gildea@holly_gildea26 Mar 2022
Congratulations to @tayladhunter who has been awarded the Goldwater Scholarship! The Goldwater honors outstanding undergrads pursuing research science. If you're recruiting for MD/PhD programs, take note!! Big things coming her way 🎉🥳
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Excited to share our new paper! We found that aged mice exhibited an exaggerated UPRER signature - lipid and protein synthesis overall were more suppressed, however, canonical UPRER proteins were translated at higher rates in aged mice under ER stress. onlinelibrary.wiley.com/doi/…

Aging alters the metabolic flux signature of the ER‐unfolded protein response in vivo in mice

Exaggerated unfolded protein response ER signature in aged animals, with higher translation of ER stress-related proteins, lower translation of all other proteins, lower rates of de novo lipogenesi...

onlinelibrary.wiley.com
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Hi Twitter! The Dillin lab is hiring a senior mouse technician to manage our mouse colony and assist with experiments in our studies of aging and stress response. Feel free to share this with anyone who you may think is interested! hhmi.wd1.myworkdayjobs.com/e…
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Dillin Lab retweeted
David Meyer@Meyer_DH7 Feb 2022
And another preprint from @dillinlab @philfrankino @holly_gildea showing that overexpression of hsf-1 in only the 4 glial cells of #Celegans is enough to induce a heat shock response and longevity 9/7 biorxiv.org/content/10.1101/…
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Another preprint from our lab is up now. In this one, @philfrankino et al. found and characterized a role for SKN-1 as a surveillance factor. Turns out it can monitor and respond to genetic perturbation of amino acid catabolism pathways and alter multiple stress resistances!
bioRxiv@biorxivpreprint4 Feb 2022
SKN-1 is a metabolic surveillance factor that monitors amino acid catabolism to control stress resistance biorxiv.org/cgi/content/shor… #bioRxiv
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Check out our latest paper by graduate student @holly_gildea which describes how glia can signal a pan organismal heat shock response independent of canonical neuronal circuits! Great work, Holly and team! @UCBerkeleyNeuro @berkeleyMCB
Holly Gildea@holly_gildea1 Feb 2022
Ta da!! Pre-print up now! biorxiv.org/content/10.1101/…

Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory...

As organisms age, they lose the ability to induce appropriate stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protect...

biorxiv.org
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