@DEOlsonLab

We develop plasticity-promoting neurotherapeutics through a combination of chemistry, molecular/cellular biology, and behavioral neuropharmacology.

olsonlab.org/
Joined September 2020
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  • Following213
  • Followers2.7K
103Media
Check out our latest paper in Nature Neuroscience (rdcu.be/ey7yk). This was a great collaboration with some very surprising results! Seems a glutamate burst & proximate IEG expression might not be necessary for structural plasticity induced by 5-HT2A partial agonists.
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I love all of our papers equally, but I might love this one a bit more. Rare to see complex molecule total synthesis, molecular neuroscience, and behavioral neuropharmacology in the same paper! Thanks to everyone who helped make this work possible pnas.org/doi/10.1073/pnas.24…

Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential | PNAS

Decreased dendritic spine density in the cortex is a key pathological feature of neuropsychiatric diseases including depression, addiction, and sch...

pnas.org
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follow us on Bluesky! @deolsonlab.bsky.social
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Check out our ibogaine total synthesis in @NatureChemistry! This was a tough project that took nearly a decade to complete by @UCDavisIPN researchers. Includes the synthesis of the unnatural enantiomer of ibogaine and ibogaine analogues that modulate SERT nature.com/articles/s41557-0…

Efficient and modular synthesis of ibogaine and related alkaloids

Nature Chemistry - Preliminary clinical trials suggest that ibogaine and its active metabolite noribogaine have powerful anti-addictive properties, Now, a strategy for the scalable, asymmetric...

nature.com
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Exciting new research in @ScienceMagazine from the labs of IPN researchers @tinakim_neuro @DEOlsonLab reveals that the neural circuitry mediating the anti-anxiety and hallucinogenic effects of #psychedelics are distinct. @UCDavisCNS @UCDLandS @UCDavisMed science.org/doi/10.1126/scie…

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states

Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the...

science.org
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Check out our latest collaboration in @ScienceMagazine Magazine with @tinakim_neuro's lab, where we re-activate psychedelic-responsive neurons to induce an anxiolytic effect without a head-twitch response. science.org/doi/10.1126/scie…

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states

Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the...

science.org
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Exciting news! We've launched a crowdfunding campaign for a new art installation in the Chemistry Building! 🎨 Help us raise $5,000 for the amazing artists! Every contribution and share counts. Let’s create something extraordinary! 🙌💙 Join us: shorturl.at/jL8rb
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IPN faculty affiliate @tinakim_neuro and team just published in @naturemethods about a protein-based tool expected to aid in identifying how #psychedelics impact brain disorders by tagging neurons activated by psychedelics. nature.com/articles/s41592-0…

Rapid, biochemical tagging of cellular activity history in vivo

Nature Methods - CaST is a Ca2+-activated version of split-TurboID. The tool allows labeling active neurons quickly, simply by administration of exogenous biotin, thus enabling the study of...

nature.com
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Check out our latest collaboration with Christina Kim's Lab in Nature Methods: nature.com/articles/s41592-0… The number of neurons tagged with CaST in the PFC following psilocybin administration correlated with head-twitch response, but the number of cfos tagged neurons did not.

Rapid, biochemical tagging of cellular activity history in vivo

Nature Methods - CaST is a Ca2+-activated version of split-TurboID. The tool allows labeling active neurons quickly, simply by administration of exogenous biotin, thus enabling the study of...

nature.com
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The newest research from IPN Director @DEOlsonLab and team suggests that tropane analogs can promote #neuroplasticity with fewer side effects than compounds like scopolamine. Read more here: pubs.acs.org/doi/10.1021/acs…

Identification of Psychoplastogenic Tropanes Lacking Muscarinic Activity

Abstract. Tropane-containing small molecules like scopolamine are a promising class of psychoplastogens. However, their potent antagonism of all muscarinic

pubs.acs.org
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Check out the latest IPN paper in J. Med. Chem. on the development of psychoplastogenic DYRK1A inhibitors with potential for treating Alzheimer's disease especially early-onset Alzheimer's disease associated with Down Syndrome pubs.acs.org/doi/10.1021/acs….

Psychoplastogenic DYRK1A Inhibitors with Therapeutic Effects Relevant to Alzheimer’s Disease

Abstract. Tauopathy, neuronal atrophy, and psychological impairments are hallmarks of neurodegenerative diseases, such as Alzheimer’s disease, that current

pubs.acs.org
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@UCDavisIPN Director @DEOlsonLab talks about psychedelics and nonhallucinogenic psychoplastogens on the @UChicago's Big Brains podcast news.uchicago.edu/psychedeli…

Psychedelics without the hallucinations: A new mental health treatment? with David E. Olson

Scientist examines how non-hallucinogenic drugs could be used to treat depression, addiction and anxiety

news.uchicago.edu
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IPN director @DEOlsonLab was interviewed for this PNAS news feature on the mechanisms of psychedelics pnas.org/doi/10.1073/pnas.23…

If psychedelics heal, how do they do it? | PNAS

If psychedelics heal, how do they do it?

pnas.org
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Within #psychedelic science, the debate lingers: Is it mind-blowing experiences or powerful #molecules that spur change? Join @TTBOOK to hear David E. Olson's take. Also available on @Spotify! youtu.be/JunhDmkrM88?si=OzEE…
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The @UCDavisIPN will be sending out their first newsletter soon. If you are interested in #psychedelics or #neurotherapeutics and would like to receive a copy, please sign up by clicking on the link on this page: neurotherapeutics.ucdavis.ed…

IPN In the Media

Sign up for our Newsletter!Our media hub features a collection of articles and podcasts that highlight the innovative work of the IPN. Explore insights from our faculty and partners as they discuss...

neurotherapeutics.ucdavis.edu
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Congrats to the Delix team on their positive phase 1 results that they are presenting at ACNP! Also, super excited that Jeff Jonas, former CEO/CIO of Sage Therapeutics, will be joining the Delix SAB! businesswire.com/news/home/2…

Delix Presents Interim Data From Phase I Trial of Novel Neuroplastogen at ACNP Annual Meeting

Delix Therapeutics, a clinical-stage neuroscience company developing novel neuroplasticity-promoting therapeutics for psychiatric and neurological disorders,...

businesswire.com
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nice article featuring @UCDavisIPN associate director @johnalangray cleveland.com/news/2023/11/a…

As Americans accept marijuana, use of LSD and other psychedelic drugs as medicine could also grow

Could wider acceptance of marijuana be leading to more open minds on research for the medical use of LSD?

cleveland.com
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article in @TheAtlantic on nonhallucinogenic psychoplastogens: theatlantic.com/health/archi…

What If Psychedelics’ Hallucinations Are Just a Side Effect?

Some neuroscientists now believe that the drugs' mental-health benefits don't come from tripping.

theatlantic.com
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our latest review covering the effects of psychedelics on neuronal physiology: annualreviews.org/doi/abs/10…

The Effects of Psychedelics on Neuronal Physiology

Psychedelics are quite unique among drugs that impact the central nervous system, as a single administration of a psychedelic can both rapidly alter subjective experience in profound ways and produce...

annualreviews.org
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great article by @Sara_Reardon in @Nature about the therapeutic mechanisms of #psychedelics nature.com/articles/d41586-0…
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