Immunogenomics Lab. Department of Pathology. Leiden University Medical Center
Joined January 2019
- Tweets183
- Following173
- Followers475
- Likes252
de Miranda Lab retweeted
Great EORTC Soft Tissue and Bone Sarcoma Group Meeting in Turin!
Thanks to all the attendees for the fruitful discussion!!
Looking forward to future steps @winanvanhoudt
@SilviaStacchia @alegronchi
@merlini_ale @SarcomaUniTo @ItaSarcomaGroup
@HuangLabICR @deMirandaLab @EORTC
de Miranda Lab retweeted
.@tvanwezel @StephSchubert @NfdeMiranda @LUMC_Leiden @dundeeuni identify a heterozygous stop-lost variant in #TP53 that specifically affects p53β isoforms and predisposes to familial cancer
#CancerResearch @NatResCancer nature.com/articles/s41467-0…
de Miranda Lab retweeted
Exciting work led by @StephSchubert! We uncover a new variant of the beta isoform of the p53 gene linked to cancer risk. A STOP loss germline mutation increases its oligomerization with the main p53 isoform, affecting its function! #Genetics #Cancer
.@tvanwezel @StephSchubert @NfdeMiranda @LUMC_Leiden @dundeeuni identify a heterozygous stop-lost variant in #TP53 that specifically affects p53β isoforms and predisposes to familial cancer
#CancerResearch @NatResCancer nature.com/articles/s41467-0…
de Miranda Lab retweeted
Happy to share the 'Behind the Paper' on our recent publication about the integration of Imaging Mass Cytometry and Mass Spectrometry Imaging.
Can't wait to see what the combination of spatial metabolomics and proteomics will teach us!
@deMirandaLab
communities.springernature.c…
de Miranda Lab retweeted
A workflow integrating imaging mass cytometry and mass spectrometry-based imaging on the same tissue sample, developed by @deMirandaLab, enables analysis of metabolic heterogeneity at the single cell level. @MEIjsselsteijn @Joana_BrasNunes @NFdeMiranda
nature.com/articles/s41592-0…
de Miranda Lab retweeted
In our latest opinion piece, @LabScheeren and I explore the complexities of HLA class I diversity in cancer immunotherapy development. Now on @CD_AACR. #CancerResearch #Immunotherapy
aacrjournals.org/cancerdisco…
de Miranda Lab retweeted
Here is deeper dive into the recent #JITC publication “Multimodal profiling of chordoma immunity reveals distinct immune contextures” by Authors: @s_vanoost, @deMirandaLab, @NFdeMiranda, @JVMGBovee from @LUMC_Leiden 1/10
de Miranda Lab retweeted
What a great start of 2024! Excited, happy and proud to share our latest work published today #openaccess @NatureMedicine on the PANDA trial: neoadjuvant atezo+chemo in pts with gastric/GEJ cancers followed by surgery. Some of the key findings below. 1/10 nature.com/articles/s41591-0…
de Miranda Lab retweeted
I am fundraising and cycling (aiming for at least 200 km) this month to support the Dutch Cancer Society @kwf_nl. 🚴♀️🚴♂️ Help us to improve the lives of cancer patients and keep our pedals spinning! 💪 Please donate and motivate:
acties.kwf.nl/fundraisers/no…
de Miranda Lab retweeted
🔬In a bid to replicate a prior study, we couldn't confirm LPS presence within breast cancer cells. We did spot it around ducts & in macrophages, aligning with its biology.
#ResearchReplication #Cancer #Microbiome
biorxiv.org/content/10.1101/…
de Miranda Lab retweeted
Registration and abstract submission for the 10th International Gamma-Delta T cell conference (Lisbon, 20-23 June 2023) is now OPEN!
For all details, including hotel recommendations, please go to:
spimunologia.org/news/gammad…
de Miranda Lab retweeted
Online now: OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum dlvr.it/SjTMY1
de Miranda Lab retweeted
Excited to start working with @GenomeMedicine as part of the Editorial Board! Looking forward to see great works in the fields of #cancer #genetics and #immunogenomics
genomemedicine.biomedcentral…
de Miranda Lab retweeted
γδ T cells unveil invisible tumors dlvr.it/Sj2PPV #immunology
de Miranda Lab retweeted
γδ T-cells are effectors in MMRd cancers with B2M loss from Voest lab in Nature nature.com/articles/s41586-0…
A hell of a paper - maybe THE paper of 2023, although I am conscious I am sticking my head out saying this in February. Reasons are.... 1/2
de Miranda Lab retweeted
Exciting news! Our Research Topic is now live in Frontiers in Immunology. We invite all researchers to share their work by submitting abstracts & manuscripts to our collection. Let's advance #cancer, #stomach, #esophagus, #omics research together! frontiersin.org/research-top…
de Miranda Lab retweeted
Cancer Discovery #ResearchWatch:
γδ #TCells Mediate Immunotherapy Response in HLA Class I–Deficient Cancers, summarizing the work of @NLdeVries, @jorisvandehaar, @vivienveninga, @MyriamChalabi, @NFdeMiranda, Emile E. Voest, et al.
bit.ly/3XuPEdc
@NKI_nl @LUMC_Leiden
de Miranda Lab retweeted
Wetenschappers van het LUMC en het @hetAVL ontdekten hoe gespecialiseerde #immuuncellen in staat zijn tot het opsporen en verwijderen van #tumoren, die ‘onzichtbaar’ zijn voor de conventionele verdedigingsmechanismen van het #immuunsysteem 👇 @Nature lumc.nl/over-het-lumc/actuee…
de Miranda Lab retweeted
LUMC-onderzoekers bieden nieuwe inzichten in de biologische processen die ten grondslag liggen aan darmkanker. Hun resultaten dragen bij aan het optimaliseren van nieuwe diagnostiek en therapieën voor deze ziekte. Lees meer: bit.ly/3u5BYbs
de Miranda Lab retweeted
Great work by @deMirandaLab at @LUMC_Leiden on the step-wise development on #colorectal cancer and #biomarker identification using #spatialtranscriptomics!
👏
xitter.cf/JessicaRoelands/status…
1/6 GeoMx DSP from @nanostringtech allowed us to compare the expression of genes 🧬 across the distinct regions in early-stage CRC samples. We observed changes in gene expression during CRC onset in (pre-) malignant epithelial cells 🟠 but also in the surrounding stromal cells 🟣
