Cardiologist @BrighamWomens | Investigator @TIMIStudyGroup | Crit Care, Shock, Heart Failure, MCS | Desert rat🌵in Boston | Married to @jencrombieMD

Boston, MA
Joined September 2018
2 ways to become famous in cardiology: 1) Work hard, contribute something meaningful 2) Hope that your name is serendipitously chosen as the acronym for a large clinical study #ESCCongress @BrighamFellows
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David Berg retweeted
🫀💊 In-hospital dapagliflozin for AHF 🩺 decongestion by week 1 → sustained through 2 months ⬇️ congestion score ⬇️ body weight ⬇️ loop diuretic dose 📈 diuretic efficiency that keeps improving Start early in-🏨 💊 Cost $5/month #DAPAACTHF @JACCJournals @TIMIStudyGroup
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In-hospital initiation of #dapagliflozin led to modest but significant improvements across multiple measures of congestion within 1 week that were sustained through 2 months. Diuretic efficiency progressively improved through 2 months jacc.org/doi/10.1016/j.jchf.… #ESCCongress #JACCHF
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Although DAPA ACT HF-TIMI 68 on SGLT-2 I in AHF is formally a "negative" trial, overall survival and subsequent meta-analytic data confirm the need for early flozination in HF patients @ddbergMD ahajournals.org/doi/abs/10.1…
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1/ In this #SimPub paper in @CircAHA from #ESCCongress, Berg et al report the findings of the DAPA ACT HF-TIMI 68 trial that investigated the efficacy & safety of in-hospital initiation of dapagliflozin in pts hospitalized for HF Here's a summary🧵 🔗bit.ly/3HyAHEg
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🚨 Hot Line 2 at #ESCCongress: DAPA ACT HF results are out! 🔹 No significant reduction in CV death or worsening HF at 2 months 🔹 Overall data still support early SGLT2i use 🔹 Safety profile consistent @escardio @ddbergMD @TIMIStudyGroup
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ESC Congress Madrid 2025 HOT LINE 2 30 August from 08:15 to 09:45 Rationale and Design of the Dapagliflozin Effect on Cardiovascular Events in Acute Heart Failure (DAPA ACT HF)-TIMI 68 Trial Optimizing guideline-directed chronic HF therapies during HF hospitalization can improve postdischarge outcomes. Limited data exist regarding the efficacy and safety of initiating SGLT2is in hospitalized patients with HF. DAPA ACT HF-TIMI 68 is a cardiovascular outcomes trial evaluating the initiation of dapagliflozin vs placebo in patients hospitalized for the management of acute HF. The trial has enrolled a high proportion of patients with de novo HF, Black race, and those treated with an angiotensin receptor–neprilysin inhibitor jacc.org/doi/10.1016/j.jchf.…
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In an analysis of pts w/cardiogenic shock from the @CCCTNetwork registry, PAHR (HR*RAP/MAP) was strongly associated with in-hospital mortality and outperformed traditional hemodynamic metrics @ddbergMD @CurtGinder #AHA24
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In contemporary CICUs, target temperatures for comatose cardiac arrest patients have shifted towards normothermia since publication of the TTM2 Trial. @rwarissmd @ddbergMD @CCCTNetwork #AHA24
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In the first look at the AHA CS Registry, clinician-assigned SCAI staging effectively stratified risk of mortality in patients with CS, supporting clinical translation of SCAI staging to a broad CS population. @ddbergMD @American_Heart #AHA24
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Dr. Robert Ariss presents his oral abstract on Trends In Temperature Control After Cardiac Arrest In Cardiac Intensive Care Units in this @CCCTNetwork analysis, tomorrow at 8am in S101A @rwarissmd @ddbergmd #AHA24
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Cardiogenic Shock session at #ACC24 Dr. Morrow @BrighamWomens discusses 🔺complexity of the syndrome 🔺complexity of care 🔺paucity of high quality evidence Need for team-based approach ⤵️
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📣Join us on 11/20 for 2024's final @SocietyOfCCC joint Journal Club, where Dr. @RickyHansra and Dr. @LSpaeth23 will take a deep dive into the management peripartum CMY patients in the CICU🤰. Together, we’ll tackle this challenging and often uncomfortable topic, making it a little less daunting for everyone!! RSVP today! 👇 🔗ccc1stop.com/event-details/c… @AnnGageMD @ElliottMillerMD @JasonKatzMD @BalimSenmanMD @Criticalecho @SarasVallabhMD @susannaprice @ddbergMD @LeivaOrly @CardsNYC @SamuelB316 @jason_bartos @PennyRampersad @AlexPapolos @Sam_Brusca @RThachilMD @PabloJ @FH_Verbrugge @HannahSchaubro1 @drdargaray @rafavidalperez @JordiBaneras @krychtiukmd @JFleitmanMD
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An approach to medical management of mixed shock states guided by hemodynamics and volume assessment. A full link to the paper: ahajournals.org/doi/10.1161/… 5/5
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📜CCCTN analysis from @ddberg demonstrates the feasibility & utility of the Shock Academic Research Consortium (SHARC) Consensus Definitions for identifying discrete subtypes of CS - each with distinct clinical profiles and 📊 prognostic implications. academic.oup.com/ehjacc/adva…
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🔥🔥 ☠️ for phenotypes along preshock -> CS continuum 👉 jacc.org/doi/full/10.1016/j.… @JACCJournals #JACCHF @CCCTNetwork 🎯 Hypoperfusion +/- hypotension -> ⬆️☠️ 🎯 normotensive CS -> distinct CS phenotype 🎯 Identify pre-& early shock to improve #CardiogenicShock outcomes
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The pre-shock ↔️ classic cardiogenic #shock continuum 💡What are the implications of an isolated low CO or isolated hypotension without end-organ injury? 💡 What about normotensive CS? Now in @JACCJournals #JACCJF from @CCCTNetwork @TIMIStudyGroup jacc.org/doi/10.1016/j.jchf.…
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