Believer • I help humans optimize their training with genetics• Head of Performance @3x4genetics• Formerly @lafc @usmnt @lagalaxy •

FITTER HUMANS Lab 👉
Joined December 2012
For years, I’ve been immersed in the world of human performance training, helping athletes optimize their strength, conditioning, and recovery. But what’s exciting to me now is how genetics is bringing impactful data to high performance. Take a gene like PPARGC1A—it’s linked to endurance. One version of it (the “Ser allele”) might help some people run faster over long distances. Scientists think it’s tied to how your body uses energy and fights fatigue. Fascinating, right? But here’s the catch—it’s not just the gene. It’s how you train with that info. So, how do we train more precisely based on a gene like this? By understanding how responsive the gene is to endurance training. Then we can program workouts that are more personalized—no more one-size-fits-all plans. This kind of insight is changing how I approach training, both for myself and the athletes I work with.
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Do you want a general approach or a personalized one? 🤷🏻‍♂️
Genetics- I have been using genetic testing for 20 years, ranging from something straightforward to something like a moonshot. A common question is intervention outside of a time machine for better parents, but the reality is what you should focus on, or what to leave alone.🧵
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Daniel Guzman retweeted
Genetics- I have been using genetic testing for 20 years, ranging from something straightforward to something like a moonshot. A common question is intervention outside of a time machine for better parents, but the reality is what you should focus on, or what to leave alone.🧵
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Mocktails with a legend, any guesses? I’m in Providence
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I founded Hype Wellness Studio in Orange County, CA to bring affordable HBOT options for people. Here’s some findings after serving all populations - the combination of PRESSURE + OXYGEN is incredible for health outcomes - a range of pressures are beneficial for health (1.3-1.6 ata has a ton of research) - spending $100k for a personal unit is not feasible for most people, finding a trusted facility is key - HBOT switches on over 8,101 genes in a single session 🧬 - this is essentially gene therapy and has shown powerful outcomes across multiple issues: TBI, post/surgery, neurodegenerative disease, etc.
HBOT ranks as one of the highest value health therapies I’ve done. Results from 60 sessions: + wiped out all systematic inflammation in my body. Below detectable levels. This is wild. + 300% increase in VEGF (formation of new blood vessels) + telomerase activity of a 12 year old, associated with biological age + 250% and 290% increase in Short-Chain Fatty Acids and n-Butyrate, respectively, important microbiome markers + complete elimination of metabolic imbalance in my gut + 28.6% reduction in a dementia marker + improved muscle oxygenation + dramatic improvements to whole body skin health The outcomes match what we observed in the scientific literature and what we predicted in deciding to do this therapy. What's notable is that after achieving elite level biomarkers over the past four years, my team and I have struggled to find new therapies that meaningfully improve my biomarkers. HBOT achieved that. 🧵
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Any running coaches or experienced runners, how were my splits? I went completely off feel as my original goal was 6:57/mile pace. 61 days of focused training for 13.1 miles today in Huntington Beach. With no previous endurance experience (outside of sports), this was completely different than anything I’ve ever done. My goal was sub 1:30. Final splits below for a 1:22:55
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All Strength Coaches guess in their programming to some extent. If you use force plates - you guess a little less If you use timing gates - you guess a little less If you use blood tests - you guess a little less When you use genetics - you guess a LOT less The goal should be better outcomes and using data to help get those positive outcomes.
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What if the key to unlocking your athletes’ health, performance, & longevity was hidden inside them all along?
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Research shows athletes using metrics like VO2 max & HRV perform better, recover faster & reduce injury risk (Journal of Strength and Conditioning Research). But these tools alone aren't enough. Adding genetic insights can unlock true potential.
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The future of performance isn’t just about the data we have—it’s about the data we haven’t unlocked. The missing link is genetics.
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If you really want to improve endurance… start with your dna
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66% is determined by genetics…
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The adoption of genetic testing in sport is here, I’ve seen it first hand over the last few years.
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If you’re interested in a personalized approach to training for your athletes…this is what is interesting to me right now.
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If you knew your genetic response to tendon health and therefore injury risk, would that impact your training decisions?
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