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The Front Cover shows efforts among Brazilian, American, and European researchers to combat neglected tropical diseases. New heterocyclic compounds originating from Brazil travel to the USA and Europe to be developed as anti‐infective agents against Trypanosomiases. #chemmedchem
Mais uma importante publicação de novos agentes anti-infecciosos para o tratamento de Leshimania, trabalho de colaboração com nossos parceiros internacionais e nosso grupo de pesquisa da USP @qhetemlab
Daniel Gedder retweeted
🆕💊 Many thanks to all those who made the 'Practical Aspects of Small Molecule Drug Discovery' course at @IPMontevideo possible 🤗!
Here is a video that summarises what happened last week 👇
cc: @eventsWCS @belamalta10 @mbishop_uk @WCAIRDundee @DDU_Dundee
O Livro Fundamentos de Química Farmacêutica Medicinal foi publicada pela Editora Manole! Uma contribuição de diversos pesquisadores da área e nosso grupo de pesquisa QHeteM da Faculdade de ciências farmacêuticas de Ribeirão Preto - USP.
manole.com.br/fundamentos-de…
Daniel Gedder retweeted
Replying to @OSantibiotics
@OSantibiotics meeting today at 4 pm UK time github.com/opensourceantibio… @MatToddChem @LoriFerrins @danielgedder @macinchem @mfernflower @emeryfs
Daniel Gedder retweeted
Molecules of the Month - Feb. 2022 | drughunter.com/molecules-of-…
A glucokinase partial activator, an orexin receptor agonist intended to promote wakefulness rather than sleep, and an orally available diacid, among others this month.
Full review in the slides~
Daniel Gedder retweeted
Molecules of the Month – Jan. 2022 | bit.ly/motm22-01
A reversible CoV-2 main protease inhibitor from Shionogi in Ph. II/III which doesn’t require a PK booster like ritonavir is the "Cover Molecule" this month.
Read more about all of them at drughunter.com~
Daniel Gedder retweeted
Molecules of the Month - Dec. 2021 | bit.ly/33CoURk
December's cover mol is MRTX1133, a preclinical candidate for KRAS(G12D) mutant cancer. Among others:
-Ph. III candidate from in vivo screening and ML-assisted data processing
-An oral HTT splicing mod for HD
Enjoy!
Daniel Gedder retweeted
Molecules of the Month - November | bit.ly/motm11-2021
Two oral SARS-CoV-2 antivirals to help tame Covid, a remarkably selective CDK7 kinase inhibitor (>4000x), and a recently approved once-daily MET inhibitor among this month's.
#chemtwitter #biotwitter #medtwitter
Estou super contente pois hoje foi a cerimônia de premiação do Small Grant 2021 da RSTMH, uma agência de fomento inglesa que financia projetos de jovens pesquisadores na área de doenças tropicais negligenciadas.
O meu projeto foi contemplado. Grato pelo reconhecimento!
O Drug Hunter desse mês apresenta uma série de moléculas e mecanismos fascinantes para o tratamento de diversas doenças. Confira!
Small Molecules of the Month - Sep. 2021 | bit.ly/smotm092021
A BLI optimized for single agent antibiotic activity, a biased agonist of S1P1 that minimizes receptor internalization, and an oral AR degrader similar to ARV-110 among the highlights
#chemtwitter #biotwitter
Daniel Gedder retweeted
The new paper from @qhetemlab is online, open and free to read. Follow the link: chemistry-europe.onlinelibra…
A Collaboration with @UAntwerpen and @WWU_Muenster. A great achievement by @danielgedder
@DNDi_Portugues @DNDi @MrBenGP
Development, SAR studies and primary in vivo evaluation of novel isoindolone-based agents against
chemistry-europe.onlinelibra…
Daniel Gedder retweeted
Molecules of the Month, Jul 2021 | bit.ly/SMOTM2107
An ER degrader in Ph. III, 4(!) neurology candidates from Takeda, two sulfoximines, and molecule gets ubiquitylated to degrade its target
Follow the team page @drughuntersite for more!
#chemtwitter #biotwitter
Agora eu faço parte do time editorial do Drug Hunter. Um excelente site para busca de informações mais atualizadas de Química Medicinal e muitas novidades sobre candidatos a fármacos. Segue o link:
drughunter.com/
@drughuntersite
Uma seleção de compostos bioativos de interesse para o tratamento de diversas doenças:
@drughuntersite
drughunter.com/small-molecul…
Durante meu pós-doutorado na Alemanha na Universidade de Münster, tive eu trabalhei na marcação biológica com flúor 18 de um composto inibidor de CCR2 e CCR5.
chemistry-europe.onlinelibra…
In this study, we modified imidazopyridine/pyrimidine and furopyridine cores at eight different positions to obtain various heterocyclic compounds as anti-infective agents.
.@danielgedder @emeryfs @USPonline @WWU_Muenster @UFSM_oficial @UWdeptMedicine @UAntwerpen report imidazopyridine/pyrimidine- and furopyridine-based compounds as anti-infective agents #antitrypanosomal #drugdiscovery onlinelibrary.wiley.com/doi/…
I have designed the Inside front cover - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/arti…
Publicamos um estudo com potenciais compostos para o desenvolvimento de fármacos para o tratamento de Doenças de Chagas na revista RSC Medicinal Chemistry.
#medchem #chagasdiseases
doi.org/10.1039/D0MD00097C























