@daa_lab

Stress response signaling networks, cell homeostasis, ISR, UPR and the likes!

 San Francisco Bay Area
Joined May 2020
  • Tweets24
  • Following125
  • Followers334
2Media
Very excited to have joined @Altos_Labs in the Bay Area with a fantastic group of colleagues. Looking forward to continuing our work on stress responses and cell homeostasis to understand their impact on cell health and rejuvenation reprogramming.
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Diego Acosta-Alvear retweeted
Max Wilson@maxzwilson3 Feb 2022
We just posted our investigations into the mesoscale organization of Wnt signaling components to the bioRxiv: biorxiv.org/content/10.1101/…

Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and...

Wnt signal transduction is mediated by a protein assembly called the Destruction Complex (DC) made from scaffold proteins and kinases that are essential for transducing extracellular Wnt ligand...

biorxiv.org
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Very happy to share our latest work in which we describe a new signaling feature of the integrated stress response kinase PKR: the formation of dynamic PKR clusters that serve as enzyme sinks that fine-tune PKR-eIF2a interactions. biorxiv.org/content/10.1101/…

Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering

The double-stranded RNA sensor kinase PKR is one of four integrated stress response (ISR) sensor kinases that phosphorylate the alpha subunit of the eukaryotic initiation factor 2 (eIF2α) in response...

biorxiv.org
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Shoutout to stellar postdoc @franzappa2 and team for this outstanding piece of work!
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Diego Acosta-Alvear retweeted
Max Wilson@maxzwilson22 Jan 2021
Our CRISPR-based covid test is published: tinyurl.com/y36w6yyj Added clinical evaluations since the pre-print. Hoping this helps where there are testing shortages. Thanking the amazing team-science culture @mcdbucsb department @lab_arias @daa_lab @KosikLab
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Diego Acosta-Alvear retweeted
MCDB UCSB@mcdbucsb29 Sep 2020
Silent Spread Surveillance study reveals how COVID-19 can travel silently through a community via asymptomatic carriers. mcdb.ucsb.edu/news/all/2020/…
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Diego Acosta-Alvear retweeted
CRISPR Medicine@CrisprMedicine11 Aug 2020
Four labs at @ucsantabarbara Join Forces to Develop Cheap and Accessible Cas13 Surveillance Tool for COVID-19. Read about it in our interview with @lab_arias. bit.ly/3ivmFRy #CRISPRmedicinenews #covidー19 #CRISPRdiagnostics
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Diego Acosta-Alvear retweeted
Max Wilson@maxzwilson7 Aug 2020
Our CRISPR-based Covid surveillance study results are out: tinyurl.com/y4942zud We think we caught the leading edge of a wave of cases coming through the UCSB community. Amazing work from an incredible team including @lab_arias @daa_lab @KosikLab labs.

CRISPR-based and RT-qPCR surveillance of SARS-CoV-2 in asymptomatic individuals uncovers a shift in...

Background The progress of the COVID-19 pandemic profoundly impacts the health of communities around the world, with unique impacts on colleges and universities. Transmission of SARS-CoV-2 by...

medrxiv.org
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Congratulations @tamsioul!
Matthieu Louis@tamsioul14 Jul 2020
[1/5] If you're looking for an affordable technology to create virtual sensory realities with optogenetics, check out PiVR journals.plos.org/plosbiolog…, a wonderful tool developed by @DavidTadres. It is out @PLOSBiology.
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Congrats!
Michael Goard@GoardMichael16 Jul 2020
First Goard lab paper published in @NatureComms today! nature.com/articles/s41467-0… Huge thanks to first author @_kevinsit (new to twitter). Recap of the findings in the thread below:
news-medical.net/news/202007…

New tool to increase accessibility for COVID-19 testing

A research group from the University of California Santa Barbara recently demonstrated a cost-effective, simple, and much less toxic method to isolate host and pathogen nucleic acids and proteins in...

news-medical.net
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Diego Acosta-Alvear retweeted
News Medical@NewsMedical2 Jul 2020
New tool to increase accessibility for COVID-19 testing news-medical.net/news/202007… via @ucsantabarbara @biorxivpreprint #Coronavirus #DNA #Laboratory #Pathogen #RNA #COVID19 #SARSCoV2
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Our newest tool to increase accessibility for COVID-19 testing
bioRxiv@biorxivpreprint1 Jul 2020
A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein to Facilitate the Detection of SARS-CoV-2 biorxiv.org/cgi/content/shor… #bioRxiv
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Diego Acosta-Alvear retweeted
José Carlos Ponce@CarlosPonce_Mx1 Jul 2020
Paper bonito, paper bien hecho. My first contribution in the @daa_lab, cheers!
bioRxiv@biorxivpreprint1 Jul 2020
A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein to Facilitate the Detection of SARS-CoV-2 biorxiv.org/cgi/content/shor… #bioRxiv
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Diego Acosta-Alvear retweeted
UC Santa Barbara@ucsantabarbara23 Jun 2020
#UCSB is piloting a COVID-19 research surveillance testing program with @CottageHealth and @SBCPublicHealth, with a focus on campus community members who are asymptomatic for the novel coronavirus. ow.ly/caGs50AfT8K
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Diego Acosta-Alvear retweeted
MCDB UCSB@mcdbucsb19 Jun 2020
MCDB Senior and Student Awards 2020 undergrad.biology.ucsb.edu/c…
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Congrats to Dr. Francesca Zappa, the 2020 recipient of the Otis Williams postdoc fellowship. Well done @franzappa2!
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Congrats to my first grad student Sabrina on her MA degree! Thesis seminar was lovely. Keep crushing it!
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Very proud of the work of my undergraduate student researchers TJ and Noah. Both are graduating with distinction in the major, and Noah is the recipient of the Robert L. Sinsheimer award! Congrats to you both and all graduating seniors of @mcdbucsb! undergrad.biology.ucsb.edu/c…
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