@cssmillie

Assistant Professor @HarvardMed @MGHMedicine @broadinstitute | human microbiome, evolution, mucosal immunology, computational biology

Joined October 2020
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  • Following608
  • Followers684
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Christopher Smillie retweeted
Mathieu Groussin@mgroussi25 Apr 2023
PhD opportunities to join our lab! IMPRS is a great graduate school. Check it out! Deadline for applications: May 15th - contact us if interested 😉
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Christopher Smillie retweeted
Lynne Chantranupong@Lchantran12 Sep 2022
Very excited to share our work that defines how dopamine and acetylcholine interact in the brain during decision making! biorxiv.org/content/10.1101/…

Local and long-distance inputs dynamically regulate striatal acetylcholine during decision making

Within the basal ganglia, striatal dopamine (DA) and acetylcholine (Ach) are essential for the selection and reinforcement of motor actions and decision making. In vitro studies have revealed a...

biorxiv.org
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Christopher Smillie retweeted
Martin Polz@MartinPolz22 Oct 2021
Congratulations to Fatima Hussain @fatiays and @JavierDubert on their new paper in Science describing surprising ways how bacteria in the wild defend themselves against phage. See also perspective by Perspective by Meaden and Fineran. science.org/doi/10.1126/scie…

Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages

For wild microbes, horizontal gene transfer of phage-defense elements decouples phage resistance from host core function.

science.org
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Christopher Smillie retweeted
Matan@matanhofree14 Sep 2021
We are excited to share our study on spatially organized multicellular immune hubs in human colorectal cancer cell.com/cell/fulltext/S0092… @CellCellPress. Joint effort with @karin_pelka, @chenchirps, @AnaAndersonlab, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen, many others!
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Christopher Smillie retweeted
Alex Cagan@ATJCagan20 Aug 2021
I am incredibly excited to share our preprint ‘Somatic mutation rates scale with lifespan across mammals’In this paper we provide an unprecedented description of somatic mutation across mammals. biorxiv.org/content/10.1101/… An illustrated tweetorial…[1/17]
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Christopher Smillie retweeted
Fabian Theis
@fabian_theis2 Mar 2021
Happy that our single-cell meta-analysis of SARS-CoV-2 entry genes is out @NatureMedicine. Headed by Chris Muus & @MDLuecken in a big effort of the whole @humancellatlas Lung Network, we find age&sex-dependent cell-type specific effects across 31 studies. nature.com/articles/s41591-0…
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David R. Liu
@davidrliu6 Jan 2021
Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4…
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Christopher Smillie retweeted
David Fawkner-Corbett@davefc88B5 Jan 2021
Really excited to see our work out mapping the development of the human intestine at single cell resolution. An amazing amount of work from a fantastic team. cell.com/cell/fulltext/S0092…
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Christopher Smillie retweeted
Otto X. Cordero@oxcordero5 Jan 2021
Proud to share our latest work showing that interactions between strains govern the eco-evo dynamics of microbial communities, led by Akshit Goyal @eltanin4, Leonora Bittleston @leonorabit and Gabriel Leventhal @gaberoo ... biorxiv.org/content/10.1101/…

Interactions between strains govern the eco-evolutionary dynamics of microbial communities

Genomic data has revealed that genotypic variants of the same species, i.e., strains, coexist and are abundant in natural microbial communities. However, it is not clear if strains are ecologically...

biorxiv.org
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Christopher Smillie retweeted
eLife - the journal@eLife29 Dec 2020
This year we added 3 more creature features to our Model Organisms collection 🐌 🐀 🐦 From Arabidopsis to zebrafish, these 18 essays explore what is known about the natural history of a range of model organisms and their wild relatives elifesciences.org/collection…

The Natural History of Model Organisms

Essays on the wild lives of model organisms, from Arabidopsis to the zebrafish.

elifesciences.org
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Christopher Smillie retweeted
Anna Kuchina@annabiosys17 Dec 2020
Our bacterial single-cell RNA sequencing technology, microSPLiT, is out at Science!
Georg Seelig@seeliglab17 Dec 2020
MicroSPLiT, our method for detecting gene expression states in bacteria using scRNA-seq, is now out at Science! @annabiosys @LeandraBrettner Luana Paleologu @RocoCharlie @dna_rosenberg @depaololab Alberto Carignano, Matthew Hirano, Ryan Kibler science.sciencemag.org/conte…
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