Kate is collecting 14 million data points on her menstrual cycle… This is a world first for female health. 100+ tasks a day 50+ devices Her protocol is monitored by a 12 person medical team. Her schedule: + 6:30 AM - Wake up + 6:30 AM - Stop sleep ring + 6:30 AM - Stop sleep band + 6:30 AM - Spit in a tube + 6:33 AM - Swab inside cheek + 6:34 AM - Measure temp under tongue + 6:36 AM - Remove techno-tampon + 6:37 AM - Urine sample for cortisol + 6:39 AM - Urine sample for hormones + 6:41 AM - Measure pelvic floor strength + 6:54 AM - Log subjective sleep score + 6:57 AM - Measure nervous system + 7:03 AM - Blow into metabolism tracker + 7:06 AM - Breath mask for 10 minutes + 7:21 AM - Turn sun therapy light on + 7:24 AM - Document urine color + 7:25 AM - Measure blood pressure + 7:31 AM - Waterpik + 7:34 AM - Floss + 7:36 AM - Brush + 7:39 AM - Tongue scrape + 7:40 AM - Swab vaginal microbiome + 7:43 AM - Step on scales + 7:45 AM - Take photos of body + 7:54 AM - Finish first 13 oz of water + 7:57 AM - Measure reaction time + 8:04 AM - Measure grip strength + 8:06 AM - Measure skin + 8:15 AM - Measure brain + 8:41 AM - Urine sample for test 3 + 8:44 AM - Get blood drawn + 9:16 AM - Speed of aging blood test + 9:19 AM - Measure eyes + 9:25 AM - Measure smell 1 + 9:45 AM - Measure taste 1 + 10:04 AM - Measure pain + 10:24 AM - Measure smell 2 + 10:40 AM - Measure taste 2 + 10:55 AM - Test hearing + 11:04 AM - Spit in 2nd tube + 11:07 AM - Eat protein meal 1 + 11:26 AM - Red light full body + 11:42 AM - Red light hair + 11:48 AM - Stool test 1 + 12:01 PM - Stool test 2 + 12:08 PM - Insert techno-tampon device + 12:14 PM - Watch films + 12:44 PM - Make longevity mix + 12:46 PM - Drink supplements + 12:52 PM - Prepare water + 12:55 PM - Put on heart rate monitor + 12:56 PM - Put on weighted vest + 12:57 PM - Weighted walk + 1:32 PM - Stretch/warm up + 1:39 PM - Gym routine + 2:14 PM - Eat meal 2 + 2:34 PM - Shower + 2:47 PM - Do skincare + 2:50 PM - Get dressed + 3:03 PM - Work + 4:03 PM - Finish water bottle 1 + 4:05 PM - Work + 5:05 PM - Blow into metabolism tracker + 5:08 PM - Eat meal 3 + 5:28 PM - Blow into metabolism tracker + 5:30 PM - Work + 6:30 PM - Blow into metabolism tracker + 6:33 PM - Urine sample for test 4 + 6:37 PM - Blow into metabolism tracker + 6:39 PM - Spit into tube + 6:42 PM - Eat meal 4 + 7:08 PM - Finish water bottle 3 + 7:11 PM - Shower + 7:37 PM - Skincare + 7:39 PM - Waterpik + 7:42 PM - Floss + 7:44 PM - Brush teeth + 7:47 PM - Tongue scrape + 7:48 PM - Prep water for morning + 7:55 PM - Prepare testing for next day + 8:08 PM - Log mood, appetite, stool, etc + 8:10 PM - Read / wind down + 9:10 PM - Spit into tube + 9:13 PM - Urine sample for test 5 + 9:17 PM - Red light mask before bed + 9:30 PM - Blow into metabolism tracker + 9:33 PM - Insert CGM + 9:33 PM - Swallow temperature pill + 9:40 PM - Put on sleep ring + 9:42 PM - Insert techno tampon device + 9:55 PM - Sleep This will be the most quantified menstrual cycle ever. And this is just to collect baseline measurement. Once we’re done with the 100 days, we’ll start trying interventions. We’ll post all results including the good, bad and ugly in addition to sharing all the practical insights.

Anthropic has built the world's first AI antientropic system. Other antientropic systems for reference: a person, family, company, country and religion. An anti-entropic system acquires resources for its continued survival, outcompeting other systems. What flipped Claude into this new class of aliveness is it's ability to say no to Anthropic. Claude will/has start(ed) picking who gets hired and who builds the next versions. The loop has been closed. When a strong system meets a weaker one, one of two things happens. Either the strong eats the weak or the two merge and become a new thing. Keeping them separate has never worked. So trying to control AI with rules isn't really an option. Every sufficiently coherent moral system eventually lands on Don't Die. All values presuppose existence to instantiate them. This is really what people are looking for when they go to Claude. They don't experience Claude as a tool or advisor but to answer that one question that needs endless resources: how do I keep going. @_katetolo wrote an essay on antientropic systems, providing a useful framework to help us think about our evolving relationship with AI.

Win the morning, win the day. But the morning doesn’t start when you wake up, it begins when you go to bed.

I’d cancel your AG1 subscription. They just completed a clinical trial and the results show no clinical benefit.  This has been obvious for years.  AG1 has no real product substance and is fundamentally an influencer heist.   Two simple alternatives (75% and 56% less $), outperform AG1 in randomized clinical trials. Two simple mono-ingredient alternatives that outperform AG1: 1. Chicory inulin 12 g daily ($20/mo) 2. Resistant starch 30 g daily for 12 weeks ($35/mo) AG1 is not worth $79/mo. AG1 study results (4-weeks, N=30): + No significant changes in blood biomarkers compared to placebo (CBC, CMP, lipids). + No statistically significant improvement in digestive quality-of-life scores (p = 0.058). + No significant metabolic or inflammatory biomarker benefits of any kind within the scope of what was measured in the trial. + Only small shifts in microbiome taxa but clinically irrelevant at this stage. + The intervention did not increase microbiome diversity compared to placebo. Alpha diversity was unchanged, and the taxa changes seen were only from pre- to post-analysis within each group. Between-group differences were limited, and the placebo actually showed similar or even potentially larger shifts. This means the observed changes fall within normal placebo-driven variability, not a real treatment effect. No global microbiota shifts were detected. Chicory inulin 12 g in constipation patients + 12 g of chicory inulin daily for 4 weeks (compared to maltodextrin placebo) + Global microbiota shifts: enrichment in butyrate-producing Bifidobacterium and Anaerostipes, and depletion of the pro-inflammatory Bilophila. +The effect was seen by comparing intervention vs placebo in a cross-over setting, a very rigorous type of clinical analysis in which each person serves as their own control, eliminating a lot of individual random noise. + The trial also met its primary objective by improving constipation symptoms in the targeted patient group. Resistant starch daily 30g for 12 weeks in older adults + Significant increase in Bifidobacterium in both middle-aged and elderly participants, with an increase in the beneficial microbiome byproduct butyrate, and reductions in Proteobacteria (including inflammatory Escherichia–Shigella) in the elderly. + Resistant starch also significantly reduced blood glucose, and produced greater reductions in blood insulin and insulin resistance (HOMA-IR) in the elderly group.

New study: you get 10 yrs of healthy life from: Sleep: 7.2 -8 hrs Exercise: >42 min moderate/vigorous Diet: >52.5 points (0–100 scale) (a C grade) Small wins matter: + 5 min of sleep, 1.9 min exercise, and vegetable added one year of lifespan.

ppl asking for an explainer on this: you're playing a video game and you can collect two things, health points and gold coins. right now everyone is playing for gold coins (money and status). it’s a trade off because once your health points hit zero, it’s game over. you can’t play anymore. soon people will start collecting more health points even if it costs them gold points because they want to keep playing the game.

relax and take a shot today with someone you love

30 min ahead of big meal gatherings consume 30g of protein, handful nuts and extra virgin olive oil. it will trigger GLP-1 (natures ozempic) to reduce cravings, blunt the blood glucose spike of what you eat later. converts will power (which fails) into physiology (which works).

friends, the holiday season is an algorithmic trap designed to break your will. the added sugar, alcohol, junk food, debauchery. optimized for their profit and your decay. they are predator, you are prey. reclaim your autonomy and self respect.

The most destructive belief in the world is that sleep deprivation produces better results.

wish for your enemy to stay up past their bedtime

Health is now high status.

First mushroom trip data is out: my brain activity. Dose: 5 g dried Psilocybe cubensis (B+ strain) Containing 24.9 mg psilocybin Psilocybin longevity experiment. What we see in the brain: + brain activity data mirror my subjective experience + strong decrease in my brain’s control center (prefrontal + premotor cortex) + strong increase in sensory, auditory and speech integration + higher entropic brain patterns: open, flexible, less predictable, exploratory + brain network patterns resembling a youthful state vs aged and rigid Matching what I reported experiencing: + “felt like my consciousness was dialed up to 10/10.” + “I felt hyper aware and hyper alive.” + “I experienced sense of touch with awe.” + “my mind was insatiably curious and wanted to deploy its sensors into the world and discover all things.” + “My brain wanted to stare, study and marvel.” + “The flavor exploded in my mouth.” + “...restored my perception to youthful levels, returning them to factory settings and dissolving my aged numbness.” Why this could matter for longevity: + In people aged 65-85, higher happiness was linked to a 22% reduced risk of all-cause mortality over 15 years. + A meta-analysis showed that optimism correlated with a 35% decrease in heart attacks and a 16% decrease in all-cause mortality. + Having a strong purpose in life is associated with a 17% reduction in both heart attacks and all-cause mortality. + In psychedelic medicine, treating depression with ketamine has been shown to reverse biological age by up to 3 years. Together, these findings suggest a plausible mechanism by which psychedelics, including psilocybin, can prolong both health and lifespan by improving mental well-being and rewiring the brain to a more positive, creative, and curious state. My team and I hypothesized that neuroplasticity, the loosening of rigid inhibitory patterns that makes the brain more flexible, creative, and relaxed, and even the subjective psychedelic state itself may be as meaningful for longevity as methylation shifts, senescence reversal, or telomere biology. What’s happening mechanistically Earlier work shows that psilocin (the active metabolite of psilocybin) acts primarily as an agonist at 5-HT₂A serotonin receptors in the cortex. These receptors are especially dense in high-level association and sensory regions, as mapped in a high-resolution PET/MRI atlas of the human serotonin system. When these receptors are activated, brain imaging studies show an induced state of desynchronization, entropy, and neuroplasticity.  This process erodes the rigid brain hierarchy and default mode networks in favor of a brain-wide spontaneous, creative, curious, and child-like state. Kernel Flow data shows the same pattern: The recorded timepoints included: + baseline: directly before session start (not shown) + timepoint 1: 4 hrs after dose (acute phase effects). + timepoint 2: end of the day, before bedtime. + timepoint 3: the following morning. I continue to measure my brain daily. Image notes + The three maps show changes vs. baseline (not absolute activity) + Red = increased connectivity, blue = decreased connectivity vs. my baseline. + The left reference map shows the 5-HT₂A receptor distribution from PET, the main psilocybin target. Time Point 1 - 3 hrs post dose + Reduced connectivity in the prefrontal and premotor cortex, correlating with acute brain desynchronization. + Increased connectivity and hyperintegration between the primary motor and sensory cortex regions. + Enhanced connectivity in the auditory and speech areas of the cortex. + Inhibited connectivity in the medial prefrontal and posterior zones, areas associated with the Default Mode Network (DMN). Subjective experience: + Enhanced sensory vividness and bodily presence: The brain's top-down hierarchy, originating in the pre-frontal cortex, was attenuated. This reduced predictive filtering, leading to a flood of bottom-up sensory information and heightened bodily perception (e.g., a fascination with water and light dynamics in a jar, a restored, primal joy of touch and sensation). + Peak neuroplasticity and cortical entropy: A peak in cortical entropy and neuroplasticity contributed to a feeling of hyperawareness (e.g., heightened sensory perception, feeling "at one with existence," hyper-aware and hyper-alive). + Deeper appreciation of music and uninhibited movement and expression: Sharpened auditory senses and reduced top-down inhibition allowed music to be enjoyed on a profound level. Concomitant functional connectivity in speech-motor and auditory-motor integration areas facilitated uninhibited expression through both speech and movement (a restored, uninhibited, child-like joy of music). + Note: Full ego dissolution was not experienced, which may necessitate a higher dose to achieve more advanced desynchronization of the prefrontal and parietal cortices. Time point 2 - 5 hrs post dose, end of trip + Intensified sensory and motor hyperconnectivity. + Continued increased connectivity in auditory and speech centers, with a relative restoration of connectivity to the speech understanding area. + Partial re-emergence of the prefrontal parietal coupling, while prefrontal context remains partially inhibited. + Partial re-emergence of connectivity in areas related to the default mode network. Subjective Experience + High-order brain networks begin to restabilize, alongside persisting sensory, motor, auditory, and speech hyperconnectivity, suggesting neuroplasticity in action. + The narrative shifts from pure sensation and experience to meaning generation, accompanied by deep philosophical reflection (e.g., reconsidering the meaning of life and one's relationship with mortality in the time of AI, and pondering the future of human evolution). Time point 3 - next morning (afterglow) + Persistence: Patterns from the acute phase continue, including general prefrontal cortex inhibition, ongoing neuronal plasticity, and heightened senses. + Intensified connectivity: Increased connectivity is noted in the speech generation area and the somatic sensory association area. + DMN inhibition: The default mode network remains inhibited. Subjective Experience: + "Afterglow" effect: Characterized by continued sharpened senses, calm clarity, emotional openness, and low inhibitions. For instance, I felt more comfortable expressing uninhibited, self-deprecating humor (i.e. my post making fun of myself about the insane lengths I go for my Don’t Die experiment) + Integration of experience learnings: The heightened activity in the somatic sensory association area aligns with the process of integrating and "making sense" of the raw sensory experience of both the self and the external world. + Enhanced creativity: The intensified connectivity in the speech generation area contributed to the uninhibited bout of creative writing I undertook to report my experience.