@cooltt888
 Ann Arbor, MI
Joined January 2021
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Excited to share our latest #Rieske #research published in @SpringerNature @NatureComms that details how to custom tune Rieske oxygenase reaction outcomes! @cooltt888 @LLLLLiuJianxin @MadisonKnapp19 @DavidGBoggs and twitterless others! @MichiganChem rdcu.be/dmCrR
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New in JBC press: "The NADH recycling enzymes TsaC and TsaD regenerate reducing equivalents for Rieske oxygenase chemistry." Learn more: ow.ly/EVTP50PQn0B
Figure 2. TsaC has a classical SDR protein fold.

ALT Figure 2. TsaC has a classical SDR protein fold.

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Excited to share our latest #rieske #research that uses structure-function relationships to change the reaction outcome of a Rieske oxygenase! Great teamwork by @BridwellRabbLab members @cooltt888 @AlejandroChem and twitterless Patrick! @BiochemistryACS doi.org/10.1021/acs.biochem.…

Leveraging a Structural Blueprint to Rationally Engineer the Rieske Oxygenase TsaM

Abstract. Rieske nonheme iron oxygenases use two metallocenters, a Rieske-type [2Fe-2S] cluster and a mononuclear iron center, to catalyze oxidation reacti

pubs.acs.org
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Every piece of new data collected was so exciting, rationally engineering a #rieske #oxygenase to switch substrate specificity and perform chemistry on non-native substrates. @cooltt888 @BridwellRabbLab @MichiganChem #biochemistry pubs.acs.org/doi/10.1021/acs…
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