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I was using ChatGPT for legal advice and it decided to completely hallucinate some preposterous nonsense about how growing wheat to use on my own farm somehow constitutes interstate commerce
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1501: Pope Alexander VI criticizes Gutenberg’s printing press safety
“The art of printing can be of great service in so far as it furthers the circulation of useful & tested books; but it can bring about serious evils l..it will, therefore, be necessary to maintain full control”
Pope Leo criticises Nvidia’s Jensen Huang over AI safety ft.trib.al/azwdiGc
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Chile required all gas stations to put their prices on the internet. The result? Margins went up 9%. Never forget that buyers are not the only people interested in what prices are! 1/
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Want to go out on a limb: in 10 years people will be cranky that there aren't enough data centers in poor or minority communities
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It is amazing how consistent the public preference for traditional building design is, and how uncomfortable this reality is with architects
Does the public prefer traditional architecture? Half a century of surveys find:
worksinprogress.co/issue/do-…
- Between 60 and 95 percent prefer traditional architecture;
- This pattern holds across gender, class, race, nationality and political views;
- More traditional densification schemes seem to attract remarkably high levels of survey support;
- Laypeople and design professionals respond dramatically differently, with professionals far more favourable to modern styles.
Research is still at an early stage, and many questions remain. Personally, I am particularly interested in how the public would respond to a non-traditional but richer and more decorative style? I think they might like it, but we don’t have hard evidence yet.
But the results are already puzzling. Why do people end up buying buildings that are so different to the buildings they say they prefer? How did we end up in this odd situation? What can we do about it?
Read more in @RobertKwolek's definitive review of architectural visual preference surveying.
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You are not crazy if you think that post 1940s buildings are uglier than older ones. In fact, a vast majority of people agree, according to the best survey data we have!
Professional architects like the types of buildings that most people find ugly. This explains why all the stuff that wins architectural prizes looks so horrendous. And why modern buildings in general are less aesthetically pleasing.
It's like a cabal that's depriving us of what we naturally enjoy!
Does the public prefer traditional architecture? Half a century of surveys find:
worksinprogress.co/issue/do-…
- Between 60 and 95 percent prefer traditional architecture;
- This pattern holds across gender, class, race, nationality and political views;
- More traditional densification schemes seem to attract remarkably high levels of survey support;
- Laypeople and design professionals respond dramatically differently, with professionals far more favourable to modern styles.
Research is still at an early stage, and many questions remain. Personally, I am particularly interested in how the public would respond to a non-traditional but richer and more decorative style? I think they might like it, but we don’t have hard evidence yet.
But the results are already puzzling. Why do people end up buying buildings that are so different to the buildings they say they prefer? How did we end up in this odd situation? What can we do about it?
Read more in @RobertKwolek's definitive review of architectural visual preference surveying.
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Before dying, music legend Dolly Parton said she'd want to try experimental treatments in order to help others (and plausibly offer herself a chance).
This is an exceedingly common sentiment among patients with terminal cancer. These are people for whom there is nothing left, who are dying in pain.
Yet, as my article explains, we make it incredibly hard to do so. It's a loss for the patient, especially as our treatments improve and for the broader scientific enterprise, as we fail to learn what works and what doesn't.
We need to allow people more autonomy to choose and to treat cancer, not the treatment, as the most toxic thing.
We are on the cusp of a wave of new therapies for some of the worst diseases. But the world won’t benefit unless the US fixes its drug regulatory system. My new essay for @nytimes, on how slow clinical trials are now the biggest obstacle to curing cancer.
nytimes.com/2026/09/04/opini…
- I interviewed dozens of researchers, especially oncologists at leading U.S. centers. A striking consensus emerged: science is no longer the main bottleneck to new cancer drugs. It is our ability to test discoveries in patients through clinical trials.
- The cost of starting a Phase 1 trial in America has roughly doubled over the past decade. As a result, companies increasingly take early trials abroad: Australia’s Phase 1 trial volume has nearly doubled in a decade, driven mainly by U.S. companies.
- Unfortunately, the underlying incentives are badly asymmetric: Institutions can be blamed for harms caused by moving too fast, but almost no one is blamed when patients deteriorate during avoidable delays. One doctor called the emerging system “ritualized safety over actual risk assessment.” Or as, @DavidHongMD put it: "We often forget that the biggest risk is the cancer itself."
- This problem is becoming more urgent because medicine itself is changing. Sequencing, biological engineering and A.I. make increasingly personalized therapies possible. But our regulatory system was mostly built for standardized drugs tested in large populations.
- @sytse, the co-founder of GitLab, shows what personalized medicine can achieve: after relapsed osteosarcoma and being told there were no options left, he pursued a highly individualized approach and has now been cancer-free for a year. But doing so required extraordinary resources and regulatory expertise.
- Pierce Ogden’s father was less lucky. After molecular analysis identified a drug that might target his glioblastoma, the manufacturer agreed to provide it. But administrative barriers delayed access until it was too late. “My dad was ready to try anything,” Pierce told me. “But the system is paternalistic.”
- The A.I. revolution is making this bottleneck more important, not less. A.I. relies on relevant data. Information from early-stage trials could compound with A.I. tools to achieve truly revolutionary medicines. Without the data, this is far less likely to happen.
- Another important shift is that innovation increasingly comes from academic labs and small biotech companies rather than Big Pharma. These small companies find it far harder to unable to absorb delays and regulatory barriers.
- Apart from cancer, China is the biggest winner from America's outdated medical regulations. China has a much faster trial system, with testing often starting a full year earlier. This allows Chinese pharmaceutical companies to experiment and improve medicines while American companies play with mice. Today, half of all drugs licensed by major pharmaceutical companies originate there, up from less than 5 percent only a decade ago.
- But we don't need to copy China. The best model is Australia: lots of on-site scientific and ethics reviews, and requirements that are proportionate to small, early-stage trials. Phase 1 studies there begin roughly 6–12 months faster, without any notable increases in adverse safety events.
- Operation TrialBlazer, a 2026 HHS initiative is a good start in this direction, but we need legislative action by Congress to truly make Phase I trials faster and more efficient!
I want to thank everyone who helped me with this article: everyone I interviewed and the amazing editors at the Times. This is the result of a months long journey of extensive interviews and research.
Special thanks go to those who came on the record. One of the features of the system is an atmosphere of fear, where practitioners are afraid to publicly come out and explain these issues. So anyone who does is a hero in my book!
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“meetings are both common & costly, consuming an average of 12% of work hours and 14% of firm wage bills … High-paying & high-revenue firms devote more resources to meetings”
nber.org/papers/w35706
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IQ scores only predict how well you do on IQ tests… and just a few other things
stevestewartwilliams.com/p/1…
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Interesting failure of governance at @Nature. Scientists peer review for the scientific journal for free--building up the prestige of the brand--while the Editor-in-Chief & her team get to trash the brand with politicised opinion journalism.
xitter.cf/SashaGusevPosts/status…
Replying to @clairlemon
They have a news team that functions just like a newspaper, with an editorials editor, bureau chiefs, etc. typically with reporting/journalism experience. This team is independent from the scientific peer-review team.
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Wokeness didn't end
Nature just put out an editorial praising Jason Arday, affirming the lie he was autistic & arguing he had an unmet right to see the evidence against him and respond accordingly
They argued that didn't happen, even though we all saw it
These people are liars
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It’s really important that society has institutions that can be trusted to tell the truth and to be fair and reasonable.
This editorial, which launders the reputation of an obvious conman, makes clear that Nature is no longer such an institution. What’s left?
Editorial: The death of Jason Arday must prompt deep reflection
go.nature.com/4xu6cnq
Readers added context they thought people might want to know
Arday was an academic fraud whose life story was fake. Editorial falsely treats former as unproven allegation, omits mention of latter, defames those who covered the scandal as racist. Calls him "autistic Black scholar" despite no proven autism diagnosis.
substack.com/@nathancofnas/…
theguardian.com/education/ng-i…
thetimes.com/uk/education/a…
news.educ.cam.ac.uk/230223-jason-a…
bbc.com/news/articles/…
bbc.com/news/uk-englan…
youtube.com/shorts/4kLRJvR…
youtube.com/watch?v=g28uXe…
youtube.com/watch?v=FA78tV…
x.com/benryanwriter/…
x.com/benryanwriter/…
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This is a better way to visualize Columbus’ voyages than the traditional way (that shows him traveling through a modern map)..
It looks a lot crazier and more daring when you see it as a trip into the unknown.
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I'm sure all similar pipe bursts are being reported on just as diligently
An Oklahoma data center using water-cooling technology just wasted over 3 million gallons of water during a massive pipe burst.
Readers added context they thought people might want to know
Missing important context: The leak in El Reno was not related to a typical data center, but was an illegal Bitcoin mining facility operating without a certificate of occupancy.
kfor.com/news/local/mas…
The facility was given a stop work order in 2023 and was not authorized to operate.
koco.com/article/el-ren…
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When I was younger I'd read about the Ottoman empire banning the printing press or whatever and I'd think "Why on Earth would they do that? They can't all have been that retarded, can they?" but unfortunately I get it now.
BREAKING: I just signed an Executive Order implementing the strictest standards in the nation for AI data centers — because I will not allow Pennsylvanians to be bullied by greedy developers and bulldozed by the lawyers working for these big tech companies.
Effective immediately, we’re requiring AI data centers to commit to strict environmental and transparency requirements AND receive approval from the local community if they want to build here.
That’s not all: We’re also removing ALL data centers from our Fast Track permit program and stopping any office or agency under my jurisdiction from signing an NDA with AI data center developers.
I’m putting these developers on notice and letting them know that we will not let them bully Pennsylvanians, disregard our constitutional right to clean air and pure water, and drive up our utility bills.
I’m using the full weight of my executive authority to block the objectionable, unwarranted projects and put the nation’s strictest set of protections in place.
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Elizabeth Warren comes out strongly against happy hour
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There is an anti-Cofnas hate rally in Trafalgar Square with ~15,000 attendees. If I were in London there is a real possibility that I would be murdered.
1000s of academics & journalists knew the truth about Jason Arday for more than a year. Now you know why no one said anything.
London — I’m at the memorial attended by thousands of DEI supporters and leftist radicals for disgraced academic and serial hoaxer Jason Arday. The speakers repeatedly target academic @nathancofnas for breaking the story about Arday’s plagiarism.
Labour MP Diane Abbott was one of the speakers who smeared Cofnas.
Arday k—lled himself after journalists revealed he had lied about his academic work and purported major life accomplishments. He delayed the truth by siccing police and lawyers on journalists early on.
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