Author of Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries in Genome Biology Read here: https://xitter.cf/t.co/4M3mMly06Q
Nijmegen, The Netherlands
Joined January 2010
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7 resources and 100ds of papers were curated to catalogue 1,457 human genes that fit the Molecular Function ‘sequence-specific DNA binding transcription factor’.
A GO catalogue of human DNA-binding transcription factors biorxiv.org/content/10.1101/… @biocurator @costgreekc @UCL_ICS @UCLIoN @news4go @uniprot @ARUKscientist @DementiasUK @dem_researcher #transcription @AllAboutTFs
Colin Logie retweeted
Absolutely - to both sides. I have used GO enrichment and have encountered interesting, meaningful GO enrichment, and also I flinch whenever it arises in a talk or paper.
Our paper on the CTCF site anatomy of Topologically Associating chromosome Domains (TADs) is out in the on-line journal Genome Biology rdcu.be/b6dya. #CTCF #3Dgenome
Nanni, @stefanoceri and @colinlog analyze clusters of CTCF sites, according to their orientation. Over the 5-100 kb range, divergent sites (eg <<>>) are enriched and convergent sites (>><<) are depleted. Convergent sites mark boundaries of TADs genomebiology.biomedcentral.…
Colin Logie retweeted
Nanni, @stefanoceri and @colinlog analyze clusters of CTCF sites, according to their orientation. Over the 5-100 kb range, divergent sites (eg <<>>) are enriched and convergent sites (>><<) are depleted. Convergent sites mark boundaries of TADs genomebiology.biomedcentral.…