mid-wit-certified by wife, Little League Coach, MIT baseball turned Giants/Cardinal homer, inventor 10^2+, CEO @ https://xitter.cf/t.co/5Nyr8kezJX

Bay Area / Aspen
Joined July 2009
TRAVEL THREAD: My hobby is to conduct self-guided tours when I travel for business
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I unfortunately fear this is going to be the Guardians' Endy Chavez moment. I hope I am misguided.
THIS is what October⚾️ is all about. I want to see some mf named “Petey” slam against the wall on a 46 degree night. I don’t wanna see some Japanese billionaire with a gambling problem and fake Canadian with fake teeth go for a three peat. This is baseball
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I don't know you, I know and generally respect YC founders, and I'm not here to rat you out BUT take it from a guy who told his kids he might go to jail (for reporting the results of peer-reviewed research on our website), you should delete this. Happy to introduce many people that can help.
You can have Alzheimer's for 15 years and not know it. We can finally slow it down. But only if we catch it early. So we built the earliest test for it. Saccade (YC F26)
Readers added context they thought people might want to know
Saccade markets its VR test as the "world's earliest Alzheimer's test," but its site states results "do not confirm or rule out Alzheimer’s," are "investigational research measures" and not validated for individual diagnosis. saccade.health saccade.health/assessment.html
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Probably the worst 6 months of my otherwise extremely enjoyable 27 years in Medtech. And I came to respect the FDA more coming out of it.
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First paid post among my followed?
Conceptually, I agree with @PeterKolchinsky here. Call it weight gain prevention, micro-dieting or whatever, but making a relatively inexpensive, low-dose version of GLP-1s available over the counter is where the market should be heading. In many ways, it’s moving in that direction already. We all know that telehealth operators, with ultra-lax prescribing standards, allow anyone to get a weight loss drug as long as they can afford it. The idea that these are “prescription” medications is a joke. So, why not go all the way?Most people would be happy with a bit of weight loss (or weight gain prevention)that they can buy at the local drugstore.
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The real future revenue opportunity for frontier labs (if these types of discoveries are truly boundless) is a fractional licensing structure to enable domain experts to execute. I agree, don't particularly care for academic gatekeeping. “ok cool these gene therapy results are still accurate; have fun figuring out what to do with them. It's yours, we'll take 0.1%."
man I just don’t see how people can think this matters at all “we don’t accept your claims” OpenAI: “ok cool they’re still accurate; have fun figuring out what to do with them; we’re gonna go disrupt other stuff now” the tsunami is here. institutions will adapt or not.
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It’s 2075. There is only one hospital in the entire country. It is 8 square miles in the middle of Kansas and owned by United Healthcare. Premiums are $47,000 per month. The only medications left are Ozempic and boner pills. Life expectancy is 38. Government: “I can’t believe doctors did this to us.”
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I'm so confused by this account because it doesn't seem to be Frank the Tank, is it AI what is this
Nothing annoys me more than this….
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Jon Coe retweeted
Nothing annoys me more than this….
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🚨🚨WOW! This is absolutely amazing to see that Karl Deisseroth, Peter Hegemann and Georg Nagel have won the Nobel prize in medicine for their optogenetic research! Visual optogenetics is a therapeutic modality that uses Gene Therapy to deliver a light-sensitive protein to cells in the retina. This mechanism of entering light to the eye can then stimulate these cells to produce a visual signal that is sent to the brain and thus “overriding” the retinal cells and to restore vision to vision impaired patients. This mechanism is already in clinical development and the most advanced optogenetic therapy is currently Nanoscope Therapeutics’ MOGENRY (formally known MCO-010) - an Optogenetic Gene Therapy aimed to restore vision in Retinitis Pigmentosa (RP) patients with a severe vision loss which is waiting for an FDA approval! Absolutely amazing!
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Let's maybe have you start off coaching a Little League team, poindexter. I say that lovingly as a fellow nerd, student, and former player--it works, up to a point--but it's an area of debate re: modeling and execution. And it didn't work for Little League 🤣
if i ran a major league baseball franchise i’d feed every stat imaginable into frontier ai models & basically delegate the roster construction + entire game management layer to them. no traditional manager & no gm making baseball decisions by gut ever. the manager & gm are both ai agents. for every game every pitch would update the model including exit velocity, pitch velocity, spin, fatigue, matchups, positioning, bullpen availability / usage, etc. & it would continuously simulate thousands of scenarios & make the highest expected value decision in real time. then over a 162 game season it watches every game afterward through precision cameras, grades every decision, learns from every outcome, & gets better. baseball might be the perfect sport for this. it has discrete events, absurd amounts of data, repeated situations, & a gigantic sample size. billy beane found mispriced players but this finds mispriced decisions too on every layer. can some billionaire please buy an mlb franchise & let me run this experiment pretty please? this would be the houston astros on steroids. imagine ai winning a ring? cc @JoshuaKushner
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My name is Wakefield
My name is Jose Canseco
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Is there anything that works less than Great Clips check in? I doubt it, but remain open to other nominees.
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Ms. Chris Farley, wild times y'all
shes truly such a unique candidate LMAO
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Down 3 getting 1 hit and Dave Roberts has made 3 subs. Juan Soto being one of those subbed. Dude only knows how to coach an all-star team when it's playing regular teams.
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This gotta be bait bro. No way market price is $650/night.
I Stayed at the Field of Dreams. Would you stay here for $650?
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After this blew up on SM I'm just finding out now that this is the town where I grew up. They built this store in high school--we previously had to drive 40 minutes to get to a supermarket. We visited from SF 5 months ago and shopped here. You have to be a very special kind of snowflake to have this reaction to the food selection and (omg!) rain, let alone record it. Aspen's City Market has fewer options! I would expect more from this middle-aged Montauk mom.
1. That's a rough 29 2. I genuinely thought this was satire 3. White fatigue
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Another internet baseball expert made a Mike Trout “88–91 mph” meme like he just uncovered the Dead Sea Scrolls. News flash: one off-the-cuff quote doesn’t rewrite baseball history. In 2011, I was scouting for the Padres, and one of my primary clubs was the Detroit Tigers. I wasn’t watching YouTube. I wasn’t scrolling X. I was behind home plate doing my job. Verlander could light up the radar guns at 100 whenever he wanted. Scherzer had premium-plus-plus velocity—mid to upper 90s. Porcello was 92–94 with command. Fister showed up throwing 91–93 with a filthy two-seam fastball. That was one rotation. But somehow I’m supposed to believe everyone was 88–91 because somebody made a meme? Here’s the difference: you have memes. I have years of scouting reports and hundreds of games in the ballpark. Stop trying to teach baseball history to the people who were actually there. Memes don’t beat experience. They just expose the dumbasses who think they do.
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Jon Coe retweeted
This story has laid largely dormant in my mind for 25 years. Never gone, but very hard to think about the horror of that morning and I’d rather not. This is my morning of September 11, 2001. At this point in my life, I am a pitching coach for The Brooklyn Cyclones, the Mets’ minor league baseball team. I have a sponsor’s softball game at our ballpark at 10 AM. My house in Jersey is about an hour drive away. I’m at my kitchen table having coffee, getting ready to head in at around nine. I put on the news. The traffic report mentions it’s a little heavy so I decide I’ll leave early. Just as I’m heading out the door the news breaks that a small plane appears to have hit one of the Twin Towers. I stopped to listen. The news reporter looks concerned and confused, but not panicked. It’s an unfolding moment and she’s keeping her cool. The look of disbelief was unstable; no answers, just confusion. She was trying her best, in her own way, to not create a mass panic. Whoever she was, she deserves a ton of credit, along with the other reporters who did the same thing. I head to my car and put on 1010 WINS. I decide to head up Route 36. There is a bridge that crosses the Shrewsbury River that allows a direct view to the city. When I get there, I’m in disbelief. There is smoke coming from the top of one of the towers, yet still no panic on the radio, just reporting of what is currently known. I call my daughter, who works in the city. I asked her where she is. She tells me she’s coming up the escalator from the bottom floors of the World Trade Center, exiting the subway. We stay on the phone. I hear the strain in her voice. Whatever has happened is not good and she is witnessing it firsthand. The radio does not betray the gravity of what happened. They are in disbelief along with all of us. I step on the gas, and race up 36. By now I figure I’ll turn left, head into the city, pick up my daughter, and then drive on to the ballpark in Coney Island. We get cut off on the phone. The confusion on the radio continues and escalates. She calls me back a few minutes later. “Dad, I just came up the escalator and there are people jumping out of the windows, there’s people jumping out of the windows.” I ask her how high they are jumping from, trying to get a feel for what is happening. I am not ready for what she’s about to say. “80 floors.” A second plane hits the other tower. This is a nightmare, and I begin to feel panic coming up within me. I take the Staten Island exit off of the parkway and approach the Outerbridge. I see cars stopped. Then the news comes over the radio. All bridges and tunnels are closed to the city. At the last possible moment, I turned off to the right and circled back down, heading back to my house. I’m doing over 100 miles an hour. I highly doubt a cop is going to stop me. I’m thinking, “What now?” I call my friend Lenny and say “I need your boat!” He asked me,“Where are you going?” I said, “To the city to get my daughter.” He’s well aware of what’s going on, and says, “I’m going with you.” I said, “No you’re not. I don’t know what I’m getting into. I don’t know what’s gonna happen. I don’t even know if I can get there but I have to try. I appreciate your offer, but I got it.” We plan to meet at his boat within 20 minutes. I pause going over the bridge on 36, take a look back, and it is beyond horrific. There’s people in those buildings and I hope one is not my daughter. I call my daughter back, thank God I get a hold of her, and let her know the plans. I tell her to stay at her office. “Stay there until I get there. Stay put!” I swing by my house real quick. I have an idea I’m probably gonna need my father's flag. He was an army veteran who spent time in Iwo Jima. I plan on hanging it off the side of the little boat. Hopefully that will let the authorities know I’m on the home team. I run in the house and remove it from the triangle box in which I keep it and head down to the marina. My friend’s there and insists on going. We jump in and off we go. Within minutes, a little comic relief. We need gas. Thankfully, there’s a fueling marina at Bahr’s Landing. We pull in. The young man working the pump was curious about where we are going. We fill up, he says good luck, and on our way. The radio is on. The news is still confusing but becoming clearer. Both towers have been hit. Both towers are on fire. We look at it. We see it in front of us, knowing we’re heading in. I call my daughter. I tell her I should be there within a half hour, if we lose contact, I tell her to make her way down to the ferries evacuating people off the island. “Get to the top deck and look out to the open water. I’ll be in a small boat with grandpa‘s flag hanging off the side. Get to the top deck and wave and wave. If I see you, I’ll turn around and follow the boat back. If not, I’ll keep going.” We’re a few miles out from the Verrazano Bridge. At this point, I think it’s going to be a dead end. I can’t imagine there won’t be police and Coast Guard closing off from that point. Suddenly, a small biplane with wings painted red and white appears. It is flying towards us but very erratically. I have no idea what that was about. I have my daughter back on the phone. She finally arrived at her office on Wall Street. I tell her our ETA and then she feels something. The building shakes. “Dad, what was that?” I hear on the radio, which has made this whole scenario surreal. The radio has one report, my daughter has the live report, and we’re in the middle, trying to make sense of the whole thing…it’s impossible. You cannot make sense of this moment. I hear on the radio that the building collapsed, but I tell my daughter not to worry about it. It’s probably just all the trucks and everything rumbling around. I make up some nonsensical answer, and she was not in the mood to analyze anything. She was terrified. Still no Coast Guard or police boats. We keep going under the bridge. Smoke billowing in front of us. The smell is unimaginable. It just smells like burning everything. It’s an acidic, rancid smell. Heartbreaking. Because I know what it is. We’re beginning to approach Governors Island. I tell Lenny to stay to the right, we’ll go around and then go straight towards Pier 11. So far, everything is going according to plan, a plan that is being made up as I go. I’m looking at the smoke, the haze and everything and I’m in disbelief. My mind makes up that the tower is still there. “I can see the tower Lenny, can you see the tower?” “I can’t see it.” “It’s right there.” But it wasn’t there. It was gone. It was a pile of rubble. Confirmed by the papers, worksheets and everything flying through the air over our heads. Literally, pieces of paper. Pieces of paper that somebody sitting at their desk was working on an hour ago are now floating through the air, as well as the poor soul who was doing the work. We’re around Governors Island and then, the inevitable. A small Coast Guard boat, that looks like a red inflatable boat, makes a B-line right for us. Machine gun mounted on the bow. I stand up on our bow and I’m frantically waving my father's flag that I’ve tied to the side of the boat. They come racing up in a no nonsense mood, helmets, guns, everything pointing right at us. They come right up next to our boat. “Where are you going?” “I’m going to pick up my daughter.” They turn, have a short conversation, I don’t know what’s gonna happen, then they turn back to me and say “Go ahead.” I could’ve fallen over. I call my daughter again and thankfully get through and tell her head to the water. I’m coming up to Wall Street now. We head for the pier and pull up. lt’s kind of bouncy because of all the tugboats loading people on and getting them off the island. It was organized chaos but it was organized. I have so much respect for the men and women who handled that without panic. We pull up next to the pier. It’s about a 5- or 6-foot reach to the railing. I grab it. I’m holding on, ready to let go, throw my leg over the railing, and Lenny yells, “Don’t let go!” “Why? What’s the matter?” The engine died. This is great, I’m this close and I’m gonna fall in the water. I’m holding on with one hand on the boat and the other on the railing, being stretched like I’m in a torture device. Between the current and the bouncing, I don’t know how I stayed up. The longest 30 seconds of my life when he goes, “OK, OK. I got it.” I let go of the boat and climb over the side. I tell him to circle around right here. I’ll be back. I begin to run up Wall Street. Unbelievably the first police officer I see on shore is from my hometown. He is directing people to the massive tugboats and the ferry boats getting people off of the island. He sees me and asks what I’m doing there. I explained to him that I’m going to get my daughter. He says good luck, I’ll see you at home. Seconds later, strangely, an older lady comes up to me and says, “Excuse me, aren’t you Bobby O?” “Yes I am.” “Oh, I just love you. You are so fun to watch.” Then her son, who understood the gravity of the situation, says, “OK mom, come on, we gotta go.” I thanked her and her son and went on my way. Can’t make that stuff up. I continued making my way up Wall Street. Incredibly, there’s my daughter coming down. It’s like a miracle. It’s a miracle in front of my eyes. I grab and hug her. We head back down to the water. We get to the water’s edge where the railing is, she looks down. Lenny has pulled up by then and she looks down and I said “Look, you gotta jump. There’s no other way, you’ve gotta jump.” It’s probably at least a 5-foot jump down to the deck to a bouncing boat with a wet bow being pushed around by the current and choppy water. She looks at me one last time, looks at the boat, and jumps. She lands and rolls but she is fine. I look around one last time at the surreal scene of I don’t even know what to call it. I jump down, hug my daughter again, sitting in our seats. We turn and head back down home. No one deserves this to happen to them. This weekend, I am reminded of and send nothing but respect to the individuals, first responders, ferry and tug boat captains beside me, who organized amongst the chaos to help one another on a horrific day.
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There may never be another player like him--Bobby Bonilla. He rose to prominence batting behind the greatest power hitter of all time, Barry Bonds. In the pre-Money Ball Era, there weren't enough baseball nerds around yet to highlight just how much Bonds inflated his batting numbers. Alas, the same numbers convinced Fred Wilpon(zi) and New York Mets to make Bobby the highest paid player ever in 1991 with a 5-year, $29MM contract. To say Bobby underperformed this honor is an vast understatement, crushing this then 11-year olds dreams of a playoff run. But the story didn't end there. The Wilpons were clients of the once elite (and forever corrupt) money manager, Bernie Madoff. After 8 disappointing seasons, the Mets were ready to release Bobby, but still owed him ~$6MM. And while we still didn't have baseball nerds in 1999, we had an ample supply of finance nerds in the front office. And at least one of these nerds modeled out a genius strategy to defer Bobby's remaining contract for 8-years at 8% interest, with payments of $1MM resuming 2011-2035. The Mets would pocket the roughly 8% premium they were earning from Madoff's market-beating mastery. I'd love to see that Windows '98 spreadsheet hung in the Louvre (or at least Cooperstown). Dot-com bust, the GFC, the '00s...the Madoff Mets were the canary in the Pittsburgh coalmine signaling the arrival of an era defined by financial turmoil. Happy Bobby Bonilla day y'all. And congrats to Bobby and his agents for outsmarting the "elites" 😉
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6 walks in less than 3 innings, good Lord. Maybe go with Deuteronomy 5:32 on the hat next game.
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