@cmholab

The Ho Lab @ColumbiaMed @Columbia_MI - using cryoEM to explore how membrane protein complexes mediate host-pathogen interactions in malaria parasites!

 New York, NY
cmholab.org
Joined August 2019
  • Tweets150
  • Following167
  • Followers449
3Media
Join speaker Chi-Min Ho @Columbia at #CS3Dbiologicalfunction2026. Chi-Min’s research integrates structural biology approaches to investigate host-pathogen interactions in malaria parasites. Extended abstract deadline: July 27, 2026 hubs.li/Q04p7b7x0
6
10
3,340
Do NoT miss this master piece from @cmholab ! Gorgeous use of the full capabilities of CryoEM ! Structural basis for host membrane binding and remodeling by invading malaria parasites: Cell cell.com/cell/fulltext/S0092…

Structural basis for host membrane binding and remodeling by invading malaria parasites

Isolation and high-resolution structure of the moving junction protein complex from invading malaria parasites reveals an intricate molecular machine that bridges the host-pathogen interface and...

cell.com
1
6
25
2,168
The Ho Lab retweeted
Chi-Min Ho@mimi1inhJun 30
Incredibly proud of Messi Haile @mehsehret, a @cmholab founding member, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @CellPressNews ! tinyurl.com/4p3md2eb 🦠❄️🔬
8
36
1
120
7,110
The Ho Lab retweeted
Chi-Min Ho@mimi1inhMay 19
So incredibly excited and grateful to be joining the Burroughs Wellcome Fund PATH family! Thank you @BWFUND and the selection committee members for supporting and believing in our vision, and congrats to the other 2026 PATH Investigators!!! 🥳
BWFUND@BWFUNDMay 19
BWF Announces the 2026 Investigators in the Pathogenesis of Infectious Disease bwfund.org/news/bwf-announce… #bwfpath
The Burroughs Wellcome Fund is pleased to announce the recipients of the 2026 Investigators in the Pathogenesis of Infectious Disease (PATH) awards, recognizing assistant professor-level scientists whose research is advancing understanding of infectious disease mechanisms and informing new approaches to prevention, diagnosis, and treatment.

ALT The Burroughs Wellcome Fund is pleased to announce the recipients of the 2026 Investigators in the Pathogenesis of Infectious Disease (PATH) awards, recognizing assistant professor-level scientists whose research is advancing understanding of infectious disease mechanisms and informing new approaches to prevention, diagnosis, and treatment.

3
7
31
2,499
The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation biorxiv.org/content/10.1101/…

The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the...

Many eukaryotic proteins are modified with a polyubiquitin chain and then recruited to either the Cdc48 ATPase (p97 or VCP in mammals) or the 26S proteasome by conserved cofactors. They can then...

biorxiv.org
3
12
1,521
Happy to share our new review of kainate receptor structure and gating. @shantigangwar @MariaKarela3 @LauraYen42 frontiersin.org/journals/pha…
4
10
2
66
5,659
The Ho Lab retweeted
Chi-Min Ho@mimi1inh20 Oct 2025
Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM
1
27
2
99
7,588
Great work from @YueJianUSTC @YaleMicroPath @YaleMed in @PNASNews #Legionella #T4SS pnas.org/doi/10.1073/pnas.25…

In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper...

The Dot/Icm machine of Legionella pneumophila is among the most versatile type IV secretion systems (T4SSs), capable of translocating more than 330...

pnas.org
8
1
36
2,331
New online! Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting bit.ly/4n7AJC4
18
2
63
3,507
Structures of kainate receptor channel GluK2 in the apo closed and open conducting states, both with 2-fold symmetrical LBD layer. To open the channel, we used agonist kainate and positive allosteric modulator BPAM but no Concanavalin A! @shantigangwar nature.com/articles/s41594-0…
5
10
2
55
4,099
The Ho Lab retweeted
Chi-Min Ho@mimi1inh18 Aug 2025
Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳rdcu.be/eBbrH Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo
6
43
1
197
10,515
The Ho Lab retweeted
Chi-Min Ho@mimi1inh2 Apr 2025
Thank you so much @hypothesisfund and @Yeh_Lab for supporting us in this new venture!! We're excited to get started! 🦠🔬❄️
Hypothesis Fund@Hypothesisfund2 Apr 2025
Replying to @Hypothesisfund
3/ Awardee @mimi1inh tackles the complex challenges of protein sequencing by leveraging molecular machinery made by microbes. Her work could revolutionize how we study protein function + structure, & our understanding of biology🤯. 🥳Congrats Dr. Ho! @Columbia 🙏#HFScout @Yeh_Lab
3
7
33
2,774
3/ Awardee @mimi1inh tackles the complex challenges of protein sequencing by leveraging molecular machinery made by microbes. Her work could revolutionize how we study protein function + structure, & our understanding of biology🤯. 🥳Congrats Dr. Ho! @Columbia 🙏#HFScout @Yeh_Lab
1
4
1
11
3,803
🌠 We're thrilled to announce our latest @HypothesisFund awardees and their groundbreaking projects! From optimizing enzymes, to protein sequencing, and membrane 'functional hotspots', each of these projects holds the potential to be broadly transformative for science! 1/ 🧵
1
4
1
29
3,410
Endogenous structure of antimalarial target PfATP4 reveals new class of apicomplexan P-type ATPase modulators biorxiv.org/content/10.1101/… #biorxiv_micrbio

Endogenous structure of antimalarial target PfATP4 reveals new class of apicomplexan P-type ATPase...

The Plasmodium falciparum sodium efflux pump Pf ATP4 is a leading antimalarial target, but suffers from a lack of high-resolution structural information needed to identify functionally important...

biorxiv.org
6
14
1,099
Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥 Thrilled to present part 2 of my postdoctoral work with @NogalesLab @CollinsRNPLab @berkeleyMCB where we investigate this using #CryoEM and transgene insertion in 🧪 and cells!
4
58
5
272
50,661
The Ho Lab retweeted
Lander Lab@LanderLab14 Nov 2024
The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.1101/…
4
32
1
123
8,515
Love when Malaria gets a MOM shoutout! pdb101.rcsb.org/motm/299 @LlinasLab @mimi1inh

PDB101: Molecule of the Month: Malaria Parasite PTEX

The parasite that causes malaria exports hundreds of proteins to remodel the cells that it infects.

pdb101.rcsb.org
2
7
759
The Ho Lab retweeted
Chi-Min Ho@mimi1inh18 Jun 2024
So excited to be joining the Pew Scholar family! Thank you @pewtrusts for supporting and believing in our vision and congrats to the 2024 class of scholars!!! 😊 pew.org/3KXaxJr

37 Researchers Working to Transform Biomedical Science

Biomedical researchers are on the front lines of scientific innovation. From responding to global pandemics to pioneering lifesaving cancer treatments, these researchers push past scientific bounda...

pew.org
34
5
1
131
10,975
The Ho Lab retweeted
Chi-Min Ho@mimi1inh18 Jun 2024
We have a fully-funded postdoc position in the @cmholab in #NYC to study how #membraneproteins drive host-pathogen interactions in #malaria parasites using #CryoEM and #CryoET!🦠❄️🔬Email [email protected] with your CV to apply! tinyurl.com/5n96rkfm #teamtomo
1
81
3
146
24,908
Load more