GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it. That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders. With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets. openai.com/index/scaling-ai-…

So basically, today PHP got two critical bugs that let anyone run code on your server without even logging in, which is bad, and then the details leaked before the patch was even out, which is worse, and it works on WordPress and MediaWiki and Magento and Joomla and Laravel, and Censys says like 1.5 million servers are running a version with no fix, so the NSA was like "take your system offline," and the FBI was like "take your system offline," and CISA and the UK and CERT-EU were all like "take your system offline," and then the Prime Minister of Japan, the actual Prime Minister, posted at 5:55 in the morning telling 48.8 million people to take their system offline, so everyone took their system offline, like the Dutch cybersecurity agency took its own website offline, and the Dutch parliament went offline, and the Port of Rotterdam went offline, and Finland and France and Denmark started pulling government sites, and Wikipedia went down, and Archive.org went down, and Asana and GOG and Something Awful went down, and the University of Vienna's webmail went down for some reason, and that's just PHP. Because GitLab also dropped a CVSS 10.0, which is the highest score they give out, for a bug that's been there since 2014, so that's every self-hosted GitLab for twelve years, and then LiteLLM 1.107.0 got hijacked and shipped a credential stealer and a remote access trojan in every single wheel and the Docker images, including latest, and you didn't even have to import it, just installing it was enough, and it's the second time this year, and then Railway paused every deployment on the entire platform because someone got into the environment variables, so now everyone has to rotate every secret they've ever stored there, and TiDB Cloud said someone was walking around inside with stolen credentials for basically a month and an extortion group says they took 10.6 terabytes, and Zeabur got breached for the second time in two months and is just shutting down, like the whole company, and Node.js patched remote code execution and a TLS bypass, and CISA says Plex is being actively exploited, and someone took over 300 Tor exit relays to steal SSH passwords, and SafePay ransomware has hit over 600 critical infrastructure orgs, and India's biggest bank filed a data loss incident, and Japan has been in an official state of emergency in cyberspace since October 9, which honestly explains the 5:55 AM post. Oh, and eMudhra, a certificate authority that's issued over 60 million certificates, whose entire job is proving websites are who they say they are, was supposed to be using private keys that are random numbers over a hundred digits long, and one of them was 4. Just 4. And the others were like 66 and 237. Anyway, it's Wednesday.

想象一下你的架构是 nginx 反向代理，后面挂着 PHP 8.1 主站、Node.js 24.x Brotli 网关、Go 微服务、Rust TLS 校验层、Python + LiteLLM 1.107.0 AI 中台，全部跑在 Linux 内核 c6e50df8 之前，HTTPS 证书由 eMudhra 签发并通过 emSign 交叉认证，根证书库用 Go crypto/x509 + Rust webpki-roots + Python certifi，CI 昨晚刚从 PyPI 拉了新包

🚨 CRITICAL: GitLab flaw (CVSS 10.0) affects 12 years of releases. CVE-2026-110264 could allow unauthenticated remote code execution on self-managed servers. Read - thehackernews.com/2026/10/cr…

one day you wrote console.log("here") for the last time and didn't even know it

Subiéndome al trend de ingeniería inversa y vibe coding: hice en Unity un visualizador de películas en Dolby Atmos, en cualquier layout de bocinas (desde 5.1.2 a 11.1.8). Lo más decente para ver algo así era con un procesador de al menos 20 mil dólares. Opus 5.5 lo hizo en menos de un día.

A Senior Engineer in Europe earns less than a Junior Engineer in the US

Distinguished engineers (E9) at Meta make $3,251,000+ per year. Among tens of thousands of strong engineers at Meta, <<1% of them are E9. One thing I've seen common among all of them is that they are world-class writers.

Cuando hablan de comentar su código a que se refieren? Xq en los trabajos que he estado estaba determinantemente prohibido dejar comentarios en el código. Se supone que el código debe ser limpio y claro por lo que con solo leerlo se interpreta.