Christopher Huff (@christopherhuff) header
Christopher Huff (@christopherhuff) profile picture

Great Lakes sunrises/sunsets, financial markets, tech, CHD2 rare disease dad 💪

Joined February 2008
Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)Photo by Christopher Huff (@christopherhuff)
Christopher Huff retweeted
Militia Capital is hiring a quantitative engineer in Austin. AI is probably going to eat discretionary investing in the next 10 years. We want to create AI tools and trading systems that distill and improve the judgment of our portfolio managers. We're not a HFT/MFT shop and don't expect to compete there; we're trying something different, which is to automate and trade on superior qualitative forecasts over weeks, months and maybe years. We're looking for exceptional statistics/ML, problem-solving and engineering ability. Finance experience is optional. Exceptional graduates and candidates from other technical fields are welcome. Pay: $275K base, $300K-$500K target bonus, depending mostly on your contribution to profits. Email sam@militiacapital.com with your resume and a short description of your hardest technical project (research, open-source work, etc.), ideally with a link to it. I can't reply to everyone, and I apologize for that.
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Christopher Huff retweeted
Dems have been completely coopted and corrupted by this crazy nonsense right at time when we need rule-of-law leadership based on first principle thinking and freedoms. I cannot emphasize strongly enough that this is a cancer eating our country.
I'm not voting for anyone who thinks the wrong side won the Cold War or cheers for the Intifada like it's the World Cup.
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Christopher Huff retweeted
Extended interview: Former Nebraska senator Ben Sasse has metastatic pancreatic cancer. He spoke with 60 Minutes' Scott Pelley about where America has been and where it could still go.
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Christopher Huff retweeted
In December 2025, former US Senator @BenSasse announced that he had been diagnosed with stage 4 pancreatic cancer. That's the primary topic for this @UncKnowledge conversation about mortality, faith, and what truly matters when time is short. Talking to host @P_M_Robinson, Sasse reflects on "redeeming the time"—holding ambition lightly, loving family more deliberately, and resisting the urge to make politics or professional success the center of life. The discussion also covers Sasse's thoughts on the failures of Congress; the dangers of a fragmented, attention-starved republic; the crisis of higher education; and the moral challenges of technological abundance. He speaks candidly and movingly about regret, forgiveness, prayer, and suffering—arguing that while death is a real enemy, it does not get the final word. Watch the full conversation on X:
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🎉Coalition to Cure CHD2 has granted €100,000 to Dr. Nael Nadif Kasri to advance personalized medicine for CHD2-related disorders. He & Dr. Elly Lewerissa will explore a novel approach using antisense oligonucleotides to ⬆️CHD2 protein expression. More: curechd2.org/p/2025grant-Kas…
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Christopher Huff retweeted
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/20…
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Christopher Huff retweeted
The problem with video games is they are essentially nothing. An absence of anything real in the actual world. Just time wastes in abstraction while the real world collapses. Social media can become the same thing too. Social media for social media's sake can be exactly that. Just totally lost in delusion or abstract theory can be that. Torrents of idiotic memes can be that. Pure detachment from real self can be that. This is why it's always important to be drawing back to the actual, using the digital realm to to communicate that which can enrich the real, to build up one's life (and the lives of others). To lead to action in hopes of living a better, and more fulfilling (real) life. This is my definition of positive social media use.
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Organizing and electing better local & state leaders in 2026 & 2027 like via @RiseChicagoOrg, or running for office yourself. There isn’t much else anyone can do until then, besides keeping the morons and kleptocrats in office at bay by loudly and publicly opposing their stupid and dangerous ideas. @christopherhuff
How does one help to start turning the ship? The Twitter discourse is doing nothing other than making me look at real estate elsewhere.
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Christopher Huff retweeted
Can confirm this story. As head trader at Enron when it filed for bankruptcy, I received many calls from firms that were recruiting. I was busy trying to close out the trading book and wanted to take some time to decide my future so didn’t take any meetings. But Citadel was by far the most aggressive. Other companies set up a few interviews with Enron’s senior people. Citadel interviewed seemingly everyone in the trading operation, all functions at all levels. Citadel's team called me twice but I declined to meet. It was apparent to me that their intent was to reverse engineer the business and I wasn’t going to help them. They knew that people looking for a job, particularly if they didn’t have a fiduciary responsibility to a current employer, would be very free with info. Interview everyone and you get a 360 perspective of the industry, how the business makes money, its competitive edge, who the best employees are, etc. Citadel probably interviewed several hundred Enron employees. In the end, they maybe hired 5. Much more importantly, they built the framework for how to enter the energy business, which, as Ken notes below, has been an enormous success. I did eventually talk with Citadel. On their third call to me, they asked if I would talk with Ken directly. I was at the airport heading to Aspen for a quick industry event. I didn’t know Ken personally but had great respect for what he’d built and so told his rep he could call me when I got back to Houston the following week. She said great, but called back a few minutes later with a question: if Ken flew to Aspen to meet me in person the next day, would I? Out of respect, I said of course. The next day I had a great meeting with him and later that week he offered me a job as head gas trader. I wanted to fully run an operation and thought there was more upside if I could have my own fund so I declined. I ended up building my own firm starting with traders and hiring deep fundamentals expertise. Citadel started with the research (as is their DNA) and built up a trading operation around it. Both models worked fabulously well. I came away from the experience with an even deeper respect for both Ken and Citadel and remain friends with him to this day. I started with a niche, gas trading, built a niche fund and burnt out after 17 years. Ken started with a niche, convert arb, and built one of the most successful financial firms ever and has never tired. blurb below via @ByrneHobart
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Christopher Huff retweeted
Sitting in my room drinking coffee on Mackinac Island this morning I am remembering one of my favorite stories of 2024. I went to another island - Beaver Island - in the late fall to write about bizarre and obscure history, and life on the island today for @mich_enjoyer
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Christopher Huff retweeted
A useful practice: Translate your sentiment into option surface thinking. For example, a reasonable posture right now is bullish but also that's consensus. Ofc course consensus can be right just not have such a great risk/reward. But that's a bit fuzzy...
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Excited to see CCC's peer-reviewed paper, A Roadmap to Cure CHD2-Related Disorders, has been published in Therapeutic Advances in Rare Disease. Kudos team! #curechd2 @Stephkprince @chaserrdad @hcmefford @ebonkowski @Csaninocencio @CarvillLab @chrismcgraw82 journals.sagepub.com/doi/10.…
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Christopher Huff retweeted
Chicago’s potential as a city is so much greater than our current reality. But I’m confident that if we do the work, we can make progress toward a better future for the city and all its stakeholders. Hope you’ll follow along and join us.
Rise Chicago advocates for inclusive, innovative & practical solutions to restore Chicago’s future We’re focused on educating our electorate & finding new leadership Join our newsletter & follow us to stay in the loop Together we can rise, Chicago! risechicago.org
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*FACULTY* positions open for #pediatric #neuroscience #Genetics #RareDisease #PrecisionMedicine program @StJudeResearch! 🧵 Seeking PhD +/- MD doing basic / transl research to understand/treat neurogenetic disease. JOIN US! 🧠🧬 #academicjobs Plz RT! talent.stjude.org/faculty/jo…
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In case you missed it, our latest newsletter is available! You can read it here: tinyurl.com/SummerNews2024 Sign up to get it delivered to your inbox: curechd2.org/signup-newslett… #CureCHD2
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Congrats to @hcmefford for Rare Epilepsy Partnership Award to study the methylation signature of CHD2-related disorders to help clarify VUS Dx + predict CHD2 symptoms & traits. @CureEpilepsy & @curechd2 are joint partners, co-funding this grant to accelerate CHD2 research
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Christopher Huff retweeted
It’s a true pleasure to sit down with journalists who are actually trying to get the truth rather than starting with a conclusion and looking for support. This was a great and far ranging talk. Thank you guys. ft.com/content/50188553-1aa2…
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CHD2 Awareness Day is coming up on Fri, Feb 2. A CHD2 family has offered to match all donations towards our awareness campaign, dollar for dollar, up to a total of $50,000. Please donate to help support CHD2 research! tinyurl.com/CHD2-Matching-20… #curechd2
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Christopher Huff retweeted
One of the subtle, but significant, benefits of asking LLMs like ChatGPT: There are no dumb questions, no embarrassment, no judgement, and unlimited patience. People often skip asking questions of other humans for all the reasons above. Then they're left with not knowing as the preferable outcome, when it clearly isn't the best outcome. At the very least, there will be more curiosity quenched, more questions asked. That's a good muscle to build.
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Christopher Huff retweeted
"Make no small plans..." --> Daniel Burnham, Chicago 1910. Make no plans --> Chicago government, 2023.
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