@chenchar22

Senior Scientist, AstraZeneca MIT Innovator Under 35

 Waltham, MA, USA
scholar.google.com/citations?user=lGt5BMAAAAAJ
Joined February 2018
  • Tweets290
  • Following485
  • Followers183
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It’s a great honour to be part of the 2022 IU35 @EmtechEurope and met many new friends! Respect goes to all the innovators and organizers that make our world a better place. #IU35Europe
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Here is Tulane's news story about a recent NIH Grant on nanopore-forming peptides awarded to me and my amazing collaborators: Kalina Hristova (@HristovaLabJHU) Nicoleta Bondar (University of Bucharest) news.tulane.edu/news/tulane-…

Tulane receives $1.6 million to develop nanoscale drug delivery

Creating holes in a cell is usually a bad thing, but researchers at Tulane are studying how they might create controlled nanopores to deliver targeted medicine into cells.

news.tulane.edu
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In our newest paper in Nature Communications, we show that signaling bias arises in the first step of signal transduction, across the membrane. Different EGFR ligands induce preferential phosphorylation of different tyrosines in EGFR. nature.com/articles/s41467-0…
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Our department @kclchemistry is in urgent need of computational academics. If you are an early career looking for academic posts in the UK in the area of computational chemistry linked to biology or biomaterials, please get in touch.
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I could not have said it better myself!
ACS Publications Bio & Med Chem Content@ACSBioMed25 Sep 2023
A multigenerational lineage of synthetically evolved antimicrobial peptides leads to a sequence that bypasses a common mechanism of resistance. @Zeniisha @WilliamWimley #ACSInfectiousDiseases 👉go.acs.org/6hg
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Charles Chen retweeted
Paul Macklin@MathCancer15 Sep 2023
Excited to share that our #OpenAccess @PhysiCell article is among the most cited papers in #PLOS Computational Biology in 2022. This really speaks to our vibrant community! Thank you all! #OpenSource #MathOnco @IUImpact @PLOSCompBiol Read it at journals.plos.org/ploscompbi…

PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems

Author summary This paper introduces PhysiCell: an open source, agent-based modeling framework for 3-D multicellular simulations. It includes a standard library of sub-models for cell fluid and solid...

journals.plos.org
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Cheers for Volunteers! The @BiophysicalSoc has included a write-up about me in the September Newsletter. Why? Because I volunteer my time to help the society function. Biophysical Society Bulletin | September 2023 biophysics.cld.bz/Biophysica…
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Could peptoids be used as a promising drug to defeat viruses? Here’s the recently published paper about developing several peptoids against enveloped viruses. It’s a pleasure to share my thoughts about membrane-active peptides/peptoids in this article. chemistryworld.com/news/synt…

Synthetic peptide mimics can act as antivirals

Peptoids disrupt enveloped viruses' lipid membranes as well as targeting fungi and bacteria

chemistryworld.com
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Do you work with membrane receptors? Are you interested in biased signaling? We introduce a new bias coefficient, kappa, named after awesome Kelly Karl. We want to test it on many different data sets.
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Thank you Kalina for hosting us at Johns Hopkins University today. It’s great to meet the Hristova lab and share my work experience. I’m always proud to be an alumnus of Johns Hopkins, and it’s wonderful to visit the campus and the city 😊
Hristova Lab@HristovaLabJHU26 Jul 2023
We were so happy to welcome Dr. Charles Chen @chenchar22 back to Hopkins! Thank you Charles, for visiting us and for answering all our questions about Big Pharma!
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Charles Chen retweeted
sk
@compchemm26 Jul 2023
Exciting news for the molecular dynamics community! 🧬 The Molecular Dynamics Data Bank aka MDDB is going to launch. 🚀 Here's what you need to know about this new European repository for molecular dynamics simulations data👇 #structuralbiology #moleculardynaimcs #drugdesign
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Calling all students of Chemistry from GCSE to A Level to university!🧪 Register to hear from one of Chemistry’s most exciting scientists today - @drdre4000 🙌 📅18 October ⏰16:00 - 18:00 📍Great Hall, Strand Campus (limited space) | Online Register: loom.ly/dYilhd8
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Join us in celebrating our incredible interns on #NationalInternDay! Their hard work, fresh perspectives and passion for innovation inspire us all. We’re proud to support their interests in #science and pave the way for the next generation of #STEM leaders.
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It is very pleasant when our young colleagues return to visit!
Hristova Lab@HristovaLabJHU26 Jul 2023
We were so happy to welcome Dr. Charles Chen @chenchar22 back to Hopkins! Thank you Charles, for visiting us and for answering all our questions about Big Pharma!
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We were so happy to welcome Dr. Charles Chen @chenchar22 back to Hopkins! Thank you Charles, for visiting us and for answering all our questions about Big Pharma!
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1. This week, I celebrate 25 years of being a faculty member at Tulane. A lot has happened in those 25 years, but they have passed so quickly. With small groups of students, postdocs, techs, and collaborators, we have accomplished a lot:
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Top-notch reporting by my STAT @ADeAngelis_bio Laronde, a Flagship upstart hailed as "Moderna 2.0," has been roiled by a data integrity issue that forced it to shelve lead drug programs. Dozens of employees have left, including top execs. statnews.com/2023/06/12/laro…

The inside story of how data integrity issues roiled a biotech seen as ‘Moderna 2.0’

Concerns over the integrity of key data led to major tumult at Laronde, a biotech company once seen as a potential "Moderna 2.0," according to a STAT and Boston Globe investigation.

statnews.com
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Charles Chen retweeted
Eric Topol
@EricTopol17 May 2023
Here is the link to @davidrliu's outstanding lecture @scrippsresearch. If you want to get up to speed on genome editing, it's all here. dropbox.com/s/8ldbsyp4wrg11w…
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"Foldy: a web application for interactive protein structure analysis" Provides a GUI for AlphaFold, AutoDock, & others. Server: foldy.lbl.gov/ Preprint: biorxiv.org/content/10.1101/…
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New paper with @HristovaLab describing a simple method to determine the statistical significance of the difference between any two arbitrary curves. biorxiv.org/content/10.1101/…
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Thank you to @Merck_Australia for the lovely #WomenInScience pin promoting the Empowering Progress campaign for #IWD2023, which arrived today. @wenyi_li68
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