Assistant Member @MSKPathology | Computational Oncology | Translational Biomarker Discovery | Cancer Genomics | Germline Predisposition to Cancer

New York, NY
Joined December 2012
Chai Bandlamudi retweeted
Thanks @Aiims1742 for highlighting-- and to the entire @MSKCancerCenter team for everything it takes to support this program day in and day out
MSK-IMPACT is truly the gift that keeps on giving! Cancer type-specific variation in patterns of driver alterations across 50,000 tumors (!!) cell.com/cancer-cell/fulltex… "One-third of all drivers arose in non-canonical contexts" Congratulations @MFBerger1 @DSolit & team.
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1. Tertiary Lymphoid Structures (TLSs) – on demand lymphoid aggregates that assemble in inflamed tissues/cancer to regulate immunity   But how? What molecule triggers? What cells induce?   TODAY in @Nature nature.com/articles/s41586-0…   Long-term #PDAC survivor PART4 – TLSs   🧵1/25
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Something I've observed in academia but I suspect is true in industry as well: as you become more senior, you'll find that you can be much more productive if you spend all your time being a manager and letting junior people do all the real work. But after a few years of this, you're likely to lose your skill at doing the work yourself, the opportunity to practice that skill, and the gratification of doing so that drew you to your chosen profession in the first place. And you'll probably also get worse at being a manager as you lose touch with the actual work. Avoiding managerdom is hard. You have to give up substantial short-term productivity gains. If you're in academia in a tenure track, you risk not getting tenure by being less productive. And personally I find that switching between thinker mode (deep work with no distractions for a whole day) and manager mode (a thousand quick but urgent tasks) to be highly unpleasant. When I'm in thinker mode, it kills me that people have to wait a day (often a lot more) for a 1-minute response from me that could unblock them on what they're stuck on and save them hours of work. When I'm in manager mode, it kills me that I have all these creative ideas sloshing around in my brain that I'm not able to execute on. So it's extremely tempting to perpetually be in just one mode or the other. When you have a team, not managing them is not an option, but being a pure manager is an option. That makes a constant struggle to carve out time for your own work and not give in to the temptation. Note: I think this is only tangentially related to Founder Mode vs Manager Mode. It's much more related to another Paul Graham essay, Maker's Schedule vs Manager's Schedule. And Deep Work by Cal Newport is very relevant.
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Chai Bandlamudi retweeted
So happy to finally share this work! Thank you @AnnaVarghese4 @chaiband @EileenMOReilly @MFBerger1 @nikolausschultz for all of your guidance & insight 🧬 Research Briefing: doi.org/10.1038/s41591-024-0…
Excited to share our latest in @NatureMedicine✨ We present a detailed clinico-genomic landscape of pancreatic adenocarcinomas With important implications for RAS 🎯 therapies Expertly co-led by @AnnaVarghese4 and @MariaAPerry. w/@EileenMOReilly & colleagues @MSKCancerCenter
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Chai Bandlamudi retweeted
Compelling study and editorial, but the headline doesn't tell the whole story. The disparity in TMB only exists for unmatched tumor sequencing that relies on population databases for filtering. Not matched tumor/normal 🧬. (1/4) science.org/content/article/…
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Chai Bandlamudi retweeted
Very happy to share our paper on genetic ancestry inference from #MSKimpact targeted panel data. We show that we can robustly infer admixture fractions of European (EUR), African (AFR), East Asian (EAS), South Asian (SAS) and Native American (NAM) ancestries. 1/6
#ICYMI: Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort, by Arora, @MFBerger1 et al. bit.ly/3KUUlaC @MSKCancerCenter #cancerdisparities
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Chai Bandlamudi retweeted
Online today! More to say later, but for now huge congratulations to @kanikaarora316 @chaiband @CDebyaniPhD and everyone involved in this important research! #MSKimpact @MSKCancerCenter 🧬
Now online in @CD_AACR: Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort @MFBerger1 @MSKCancerCenter #cancerdisparities aacrjournals.org/cancerdisco…
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Chai Bandlamudi retweeted
Our latest manuscript studying rectal cancer is out in @NatureMedicine. This is work led by @DrGarciaAguilar, @fsanchezvega and myself, in collaboration with amazing colleagues at @MSKCancerCenter. 1/n nature.com/articles/s41591-0…
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Chai Bandlamudi retweeted
Outstanding #AACR22 talk by @chaiband going deep into #MSKimpact data from 50,000 patients to identify new cancer type associations. Not all driver mutations are equal. Lots to learn by looking at clonality and zygosity, with implications for patients. 👏👏 @MSKCancerCenter
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Chai Bandlamudi retweeted
🔴🔴Our paper is out today in @CellCellPress! Since the preprint and thanks to the reviewers, we added a validation series of 10,000+ patients, an analysis of the timing of metastases & linked different analyses to further extended the hypotheses cell.com/cell/fulltext/S0092…
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Nodal EBV+ T/NK cell lymphoma is a newly recognized lymphoma. Despite its aggressive behavior, the tumor shows remarkably low genomic instability. Find out more about this lymphoma from our new article. doi.org/10.3324/haematol.202…
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Chai Bandlamudi retweeted
Thanks to @CR_AACR and @HarmonyTurk for the opportunity to look back on 20 yrs of BRAF research. The BRAF story highlights many of the best and worst aspects of our current cancer research efforts and provides lessons for future precision oncology drug development. 1/n
Read the latest #CRLandmark by Hanrahan and @DSolit: BRAF Mutations: The Discovery of Allele- and Lineage-Specific Differences bit.ly/3FXgh1q
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How do inherited gene mutations cause cancer? A new study released today in @NatureGenet from MSK researchers provides some promising new insights. #MSKImpact @MFBerger1 @srinipr4 bit.ly/3bIMNqP
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