@cdcode_org
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CD-CODE is a comprehensive, manually-curated database for biomolecular condensates and proteins developed by @agnestothp 's lab. https://nitter.cf/t.co/tndWt4I6TJ
Dresden, Germany
Joined March 2022
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We're really excited that CD-CODE is now cross-referenced by @uniprot and has already been included in the latest release: uniprot.org/release-note...
Spreading knowledge about #biomolecular #condensates 🥳
🦋more news from us: bsky.app/profile/cdcode.bsky…
☀️summer is here - and so is CD-CODE v1.10 release!
💡CD-CODE has now 719 manually curated #condensates
💡Check out new #condensates and updated #protein - condensate connections at cd-code.org
#Bioinformatics #DatabaseUpdate #cdcode
bsky.app/profile/cdcode.bsky…
The latest release was supported by the #condesathon joined by MPI-CBG condensate community🤩 Big #thankyou to all the participants for your support and enthusiasm!💜
more news from us: bsky.app/profile/cdcode.bsky…
CrowDsourcing COndensate Database & Encyclopedia retweeted
The latest April release of @uniprot cross-links biomolecular condensate entries to CD-CODE.
uniprot.org/release-notes/20…
For example, one can see that Protein Q9VD51 is a member of the Nucleolus uniprot.org/uniprotkb/Q9VD51…
@cdcode_org @agnestothp
🍃CD-CODE update v1.09 is here!🍃
👀Check out the new #biomolecular #condensates at cd-code.org
👀We're continuing to update #Protein - #condensate connections and resolve issues!
Join us on🦋 to follow more regular updates: cdcode.bsky.social
CrowDsourcing COndensate Database & Encyclopedia retweeted
Our PICNIC tool predicts condensate-proteins regardless of their structural disorder across organisms
@NatureComms. Congratulations to @AHadarovich for developing the algorithm and to Hari @HymanLab for the experiments! @mpicbg @csbdresden @PoLDresden nature.com/articles/s41467-0…
✨Winter CD-CODE update to v1.08!✨
❄️ New #biomolecular #condensates added (total ⚪: 680)
❄️ #Protein - #condensate connections updated
❄️ Species attributes fixed 🤩
👀Check the current version here: cd-code.org
Join us as a contributor: cd-code.org/signup
🔊Calling the hive mind of the #Condensate Community: Join us in curating the CD-CODE!
Do you have a favorite condensate or have discovered one that’s not yet in CD-CODE?
We want your input and expertise!🧠
🔗Easy sign-up here: cd-code.org/signup
Add a new condensate ⤵️
🚨October Condensate of the Month is Stress Granule!
#StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses.
🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.
Various species have different Stress Granule proteomes:
🔵Translationally stalled mRNAs,
🔵translation initiation factors,
🔵RNA-binding proteins, and
🔵non-RNA-binding proteins
are among the main constituents of SGs.
☝️SG is one of the most populous condensate in CD-CODE, with human (cd-code.org/condensate/DEE66…) and yeast (cd-code.org/condensate/E03F9…) proteomes being the most characterized up to date!
Are you a stress granule expert or enthusiast?
🦉Join us as a curator: cd-code.org/signup
💫September Condensate of the Month is +TIP body!💫
These #condensates form at the growing plus end of #microtubules, crucial for cell division and transport.🦠🧫 : cd-code.org/condensate/9095A…
Check out the protein composition of +TIPs in different organisms ⤵️
These condensates concentrate proteins needed for growing tip of the #microtubule.
+TIP bodies have been described in...
...🐁mammalian cells (Wu et al., 2021),
...🧪S. pombe (Maan, Reese &Volkov et al., 2023),
...🧪S. cerevisiae (Meier, Farcas &Kumar et al., 2023 @LabBarral
📚Read more about +TIP body and its proteins:
doi.org/10.1371/journal.pone…
nature.com/articles/s41556-0…
nature.com/articles/s41556-0…
New Season 🍂🌿 - new #CDCODE release!
🥳Version 1.07 is here: cd-code.org
🌟We focused on improving #species attributions and updating missing #condensate features.
Help us with your condensate expertise!🧠
Join us to become a contributor: cd-code.org/signup
🌟Excited to introduce #MARDO as CD-CODE August "Condensate of the Month"!🌟
MARDO stands for Mitochondria-Associated RNA DOmain: cd-code.org/condensate/089DA…
💡It was first discovered and described by Cheng et al. @SchuhLab in #mammalian (mouse, bovine and human) #oocyte.
1/3🧵⤵️
🔵MARDO is a #membraneless compartment that stores maternal mRNAs, important for early embryonic development.
ZAR1, an RNA-binding protein with an intrinsically disordered region (#IDR), plays a major role in MARDO assembly and facilitates clustering with #mitochondria.
2/3
📚Read more about MARDO and its proteins:
doi.org/10.1093/nar/gkad919
doi.org/10.1007/s00018-023-0…
science.org/doi/10.1126/scie…
3/3
📢We've just updated CD-CODE to v1.06!🎉
✨11 new #condensates integrated (total: 670)
✨ 21 new #proteins associated (total: 9672)
✨ 24 condensate-protein attributes updated
👀Check the current version here: cd-code.org
#DatabaseUpdate #NewRelease #Bioinformatics
CD-Code has been updated to v1.05:
✨ 14 new condensates integrated, making a total of 659 condensates
✨ 14 new proteins associated, make a total of 9651 proteins
✨ 34 condensate/protein attributes updated
Visit our website here: cd-code.org/