Jonathan Downham, an Advanced Critical Care Practitioner working in Birmingham, UK. Developing a web teaching and podcasting resource for others.

Alcester, England
Joined February 2012
Does adding procalcitonin testing to NEWS2 improve sepsis care? The 7,667-patient #PRONTOTrial found NO change in 3h IV antibiotic initiation (48.4% vs 48.2%), but significantly reduced 28-day mortality from 16.6% to 13.6%! 🧵👇
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Why did mortality drop? The procalcitonin algorithm reclassified 24.6% of NEWS2 high-risk patients to low-risk & 33% to medium-risk. The biggest mortality benefit was in the most deprived groups—acting as a 'leveling-up' intervention to streamline care.
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Is this algorithm safe? Yes! The 90-day survival benefit persisted (20% mortality vs 23.8% usual care) with NO increase in overall antibiotic exposure (median 5 days in both arms). Safety events and readmissions were statistically identical.
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How dare you! Nurses in my intensive care ward witnessed daily deaths, swabbed our bums every day, talked to an unconscious me, held my hand, wrote my intensive care diary, saw colleagues die, had inadequate PPE, were very afraid, are still traumatised. You do it?
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The Critical Care Practitioner retweeted
Here it is. My manifesto for the 2026 Clacton By-Election. It's a once-in-a-lifetime opportunity. Join me, clean up Clacton and let's make 13th August Bin Day! #VoteBinface #VoteyMcVoteface #YesWeTinCan
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The Critical Care Practitioner retweeted
Successful ICU e-diary implementation depends on more than the technology. This multicentre study highlights the importance of training, champions, leadership and ongoing support for sustained adoption. doi.org/10.1111/nicc.70517 #CriticalCare #ICUDiary
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Any ACCPs out there from East Midlands? Need to talk to you about a one day forum we are setting up in October. #accp #ficm
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In this episode, Jonathan takes a deep dive into Diabetic Ketoacidosis (DKA) — a classic but potentially fatal metabolic emergency in critical care. traffic.libsyn.com/criticalc… #criticalcare #criticalcarenurse #intensivecare
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In this series of The Critical Care Practitioner Podcast, Jonathan explores how our understanding of mobilisation in ICU has evolved traffic.libsyn.com/criticalc…
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