@calico

Calico is a research and development company tackling one of life's greatest mysteries, the biology that controls human aging.

calicolabs.com
Joined June 2016
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Thank you to our early-career scientists for bringing your energy, fresh perspectives, and spirit of curiosity. We're grateful you're here! Here are some moments from our recent Postdoc Summit. #NationalPostdocAppreciationWeek
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September is #LeukodystrophyAwarenessMonth. Vanishing White Matter is a rare, progressive leukodystrophy that usually appears in early childhood. There's currently no approved treatment.
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Together with our partners at @ULFUnited and the Vanishing White Matter Families Foundation, we’re working to increase awareness and understanding of the disease and support the needs of this community. #VanishingWhiteMatter #Leukodystrophy #LeukoAware
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This month marks 13 years since Calico’s start. While our mission hasn't changed – to understand the biology of aging and use what we learn to help people live longer, healthier lives – our team has grown a lot since then.
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Our work now spans clinical- and early-stage programs across several aging and age-related disease areas, all of it building on the fundamental research that comes first. Thank you to our team, our collaborators, and everyone else who helped us get here.
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Read more about our story and where we’re headed next: calicolabs.com/story/our-sto…

Our Story: Taking a long-term view on tackling aging and increasing healthspan - Calico

Aging is the greatest risk factor for the world’s most common health problems, yet understanding its biology remains limited by its immense complexity. ...

calicolabs.com
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A new method for tracking protein-protein interactions in real time in living cells could open unexplored possibilities for understanding how cellular processes change with age. (1/9)
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Additional contributors include Alfred Millett-Sikking, Magdalena Preciado Lopez, Aaron Nile, Prashant Rao, Zena Jensvold, and Hannah Baddock. Lachlan Whitehead created this animation of TTM in action. (8/9)
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Read the preprint: biorxiv.org/content/10.64898… (9/9)

Triplet tumbling microscopy enables in situ quantification of protein complex assembly and dynamics

Protein-protein interactions (PPIs) mediate diverse cellular processes, but PPIs are typically characterized using reconstituted in vitro biochemical and biophysical approaches. Current approaches...

biorxiv.org
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From the beginning, we took on a challenge that still defines our work today: how to better understand the biology of aging and its role in disease.
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Today, that foundation supports our progress from discovery into clinical- and early-stage programs across multiple age-related diseases. We continue to build on our original vision, working to translate insights into potential therapies that may improve healthspan.
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Learn more about our story: calicolabs.com/story/our-sto…
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We recently joined the @PKDFoundation community at PKDCon, which brought together people living with ADPKD, their caregivers, and family members; and the PKD Centers of Excellence, a conference for nephrologists and investigators focused on advancing standards of care. (1/5)
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Learn more about how we’re advancing clinical research in ADPKD and our ongoing global Phase 2 trial: calicolabs.com/clinical-tria… (4/5)

Clinical Trial: Autosomal Dominant Polycystic Kidney Disease - Calico

calicolabs.com
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Calico's ADPKD program is investigational. No treatment based on this research has been approved by the FDA or other governmental agency and its safety and effectiveness have not been established. (5/5) #ADPKD
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