@CadwellLab

We investigate the interface between the immune system and diverse infectious agents ranging from friendly gut microbes and viruses to disease-causing parasites

 Philadelphia, PA
med.upenn.edu/cadwell-lab
Joined September 2019
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Congratulations Christin Herrmann and team for publishing this super cool discovery 😎 nature.com/articles/s41564-0… Here’s a quick summary of our cool findings about how stress due to simple mouse husbandry drives clearance of persistent enteric viral infection 🦠🐭 1/5

Environmental stress drives clearance of a persistent enteric virus in mice

Nature Microbiology - Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and...

nature.com
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Cage change is a stress-inducing event for 🐭! We found that the fluctuation of glucocorticoids (hormones released under stress) contributes to viral clearance, and interference with this hormonal stress response actually inhibits MuAstV clearance after cage change! 4/5
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Overall, we discovered that an intervention as simple as changing cages can control duration of viral infection in mice. Huge shoutout 🙏 to Christin and coauthors, the Gnotobiotics core at both Penn and NYU, and PennCHOP microbiome program for making this study possible 5/5
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Congratulations @Ipiricyao and Eugene Rudensky for publishing this story! Big 🙏to NIH for making this work possible. Here’s a brief summary of this fascinating finding about a gene variant that YOU🫵most likely have 1/n kwnsfk27.r.eu-west-1.awstrac…
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Maybe ATG16L1 T300A is under balancing selection, like hemoglobin and APOL1 variants that are protective if you have 1 copy but 2 copies are bad (sickle cell/kidney disease)🤷‍♀️? Lots of❓ surrounding mechanism that we’re continuing to work on 4/n
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Once again, 🙏NIH for making this possible and our amazing coauthors. Special shoutout to coauthors Patty Martin and @TorresVJ_Lab for launching this project. Read paper for details and credit to literature for background 5/n
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Cadwell Lab retweeted
Cadwell Lab@CadwellLab8 Mar 2025
Congratulations @YingHanChen7121 and Kim Zaldana for showing how B cells are altered when lab mice are released outdoors! science.org/doi/10.1126/scia… 1/n

Rewilding catalyzes maturation of the humoral immune system

Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.

science.org
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Congratulations @YingHanChen7121 and Kim Zaldana for showing how B cells are altered when lab mice are released outdoors! science.org/doi/10.1126/scia… 1/n

Rewilding catalyzes maturation of the humoral immune system

Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.

science.org
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Recently, we received a great score 👍on a previous NIH grant and hope we can get it funded after incorporating helpful suggestions from reviewers 8/n
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We are eternally grateful that the NIH officers and reviewers have expressed enthusiasm for these types of studies. Return in investment for the growing dirty 🐁field is huge 🤯and will help industry, and gov’t funding is essential to support the next phase! 9/n
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