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ALT Figure showing effects of once-weekly semaglutide compared with placebo on\nreduction in heavy drinking days and total alcohol consumption. Changes from baseline (week 0) to follow-up (week 26) are shown for mean percent heavy drinking days in the last 30 days (A), and mean alcohol (g) consumed during the past 30 days (B), in participants randomly assigned to semaglutide 2\u00B74 mg (n=54) or placebo (n=54). Participant level changes by treatment group are in appendix 1 (p 15). SEM=standard error of the mean. Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.