@boilingstone

Postdoctoral researcher at @BOOMchemistry @EdinburghUni | 👨🏻‍🔬💊 Chemistry, Drug Discovery, Kinases, Bodyboarding, Hot Peppers |

 Edinburgh, Scotland
instagram.com/boilingstone/
Joined September 2016
  • Tweets49
  • Following331
  • Followers101
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If you are interested in drug discovery and want to know more about all the approved small molecule kinase inhibitors, their medical indication, pharmacology and original synthesis, check out our last perspective! @ACSBioMed @EdinUni_IGC @BOOMchemistry pubs.acs.org/doi/10.1021/acs…
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Andrew Wood@AndrewWoodLab29 Apr 2024
Interested in using degron tagging to study the function of your favourite protein in genetically engineered mouse models? Check out our review covering recent work in this area: doi.org/10.1242/dmm.050613

Degron tagging for rapid protein degradation in mice

Summary: We review recent applications of degron tagging in mouse models, focusing on the challenges and opportunities for using this technology to rapidly degrade proteins of interest in mammalian...

journals.biologists.com
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Diego Oyarzún@doyarzunrod15 Jun 2023
🌞Delighted to see our work with @VSmerBarreto @jucaacoco @BOOMchemistry and the Carragher lab on featured in the press today! thetimes.co.uk/article/ai-fi… news.sky.com/story/ai-helps-…
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Diego Oyarzún@doyarzunrod12 Jun 2023
💊📢 New paper on #AI for #drugdiscovery in @NatureComms We discovered three senolytics - compounds that kill 'zombie cells' in therapies vs cancer and others #aging doi.org/10.1038/s41467-023-3… The most fun collab led by @VSmerBarreto with @jucaacoco lab #compchem #synbio
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BOOMchemistry.com@BOOMchemistry4 Jul 2022
Congrats to Shiao for her work @JACS_Au! @BOOMchemistry Excited with the potential of this targeted strategy. pubs.acs.org/doi/10.1021/jac…

Targeted Molecular Construct for Bioorthogonal Theranostics of PD-L1-Expressing Cancer Cells

Abstract. Molecular targeting of tumor-overexpressed oncoproteins can improve the selectivity and tolerability of anticancer therapies. The immunoinhibitor

pubs.acs.org
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BOOMchemistry.com@BOOMchemistry5 Jan 2022
See our last work here: pubs.acs.org/doi/10.1021/acs… After years of research, we show "Pd-triggered local chemotherapy" works in vivo and can solve inherent DMPK issues of a chemotherapy drug such as 5FU @ACSBioMed @EdinCRC @EdinUni_IGC @CRUK_BI

A 5‑FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd...

Abstract. 5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those

pubs.acs.org
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Simone Hendrikse@s_hendrikse30 Nov 2021
Interested to learn more on how molecular organisation, handedness and configuration can aid in synthetic biomaterial design? Check out our recent review here ➡️ pubs.rsc.org/en/content/arti… @ChemSocRev @rcontmont, Amanda Ellis, @PalliThordarson and @jonathan_steed
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BOOMchemistry.com@BOOMchemistry3 Nov 2021
For those interested in #bioorthogonal catalysis, check out this new application just published in @angew_chem in collaboration with @BeckerLabCRTD onlinelibrary.wiley.com/doi/…
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Interested in the chemistry behind approved kinase inhibitors? Check out the comprehensive perspective in Journal of Medicinal Chemistry by @BOOMchemistry here: fal.cn/3iYbC
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Edinburgh Cancer Research@EdinCRC14 Sep 2021
Nuvectis Pharma has licensed rights to develop and commercialize a novel, SRC/YES1 inhibitor discovered at the CRUK Edinburgh Centre @EdinCRC of the University of Edinburgh’s Institute of Genetics and Cancer @EdinUni_IGC. Read more on Yahoo! Finance 👇: finance.yahoo.com/news/nuvec…
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BOOMchemistry.com@BOOMchemistry21 Aug 2021
10 years of research culminates with this work. Our most important contribution to the cancer field. Joint effort from @EdinCRC, @MRC_CRH and @CIB_CSIC!! cancerres.aacrjournals.org/c…
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Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi mdpi.com/1173114 @MDPIOpenAccess @ISGLOBALorg @ffarmaciaUGR @genyo_pts @jjdmochon @BOOMchemistry
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Synthesis and screening of 6-alkoxy purine analogs as cell type-selective apoptotic inducers in Jurkat cells dlvr.it/S1r9XG
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Check out our synthetic strategy to diversify purine libraries for drug discovery. Online on @ChemRxiv doi.org/10.26434/chemrxiv.13… @BOOMchemistry @jjdmochon
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A further step in the development of a RIOK2 chemical probe. Congratulations to the @UNC team! @thesgconline @rsc_medchem #darkkinase pubs.rsc.org/en/content/arti…

Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine...

RIOK2 is an understudied kinase associated with a variety of human cancers including non-small cell lung cancer and glioblastoma. No potent, selective, and

pubs.rsc.org
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Grant Sanderson@3blue1brown27 Mar 2020
New video: Simulating an epidemic. What happens when people avoid each other for the most part but still go to a common central location like a store? What if you can track and isolate cases, but 20% slip through the cracks? 50%? And much more. youtu.be/gxAaO2rsdIs
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London Lab@london_lab18 Mar 2020
Calling all medicinal chemists! We released ~60 structures of fragments bound to the Mpro #SARS_COV_2. diamond.ac.uk/covid-19/for-s… We are crowdsourcing ideas for what to synthesise and test next covid.postera.ai/covid you design it and we'll test the best designs. please RT!
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The Washington Post
@washingtonpost14 Mar 2020
Why outbreaks like coronavirus spread exponentially, and how to “flatten the curve” wapo.st/39MCAqB
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Dennis X. Hu
@DennisWhom1 Mar 2020
Small Molecules of the Month, Feb. 2020 - drug-hunter.com/2020/03/01/s… Highlights from SMDD campaigns published online Jan-Feb. Grab a coffee and use this post as a starting point in getting caught up on the literature this year! PDF and links to articles in the post #chemtwitter
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